QS

Question 1

In which disease is the the nucleus basalis of Meynert affected early?

Answer 1

Alzheimer’s

Question 2

In which disease does degeneration of the midbrain lead to vertical gaze palsy?

Answer 2

Progressive supranuclear palsy

Question 3

Hemiballism is associated with what?

Answer 3

A sub-thalamic lesion

Question 4

Lumbar puncture showing 
Clear, 
normal opening pressure, 
lymphocytes present, 
high protein and
normal glucose

indicates what?

Answer 4

viral meningitis

Question 5

Lumbar puncture showing CSF with
Cloudy
elevated opening pressure
neutrophils present
high protein
low glucose

indicated what?

Answer 5

Bacterial meningitis

Question 6

Lumbar puncture showing CSF with 
Opaque (if left to settle it forms a fibrin web), 
elevated opening pressure,
lymphocytes present, 
high protein and 
low glucose 

indicates what?

Answer 6

TB meningitis

Question 7

What is the best investigation in frontotemporal dementia?

Answer 7

MRI

Question 8

What antiepileptic is most useful when a seizure occurs as a result of stroke?

Answer 8

carbamazepine

Question 9

A patient with known epilepsy presents with blurred vision and vertigo. Blood results reveal hyponatremia.

Which medication produces these side effects?

Answer 9

carbamazepine

Question 10

A mother has noticed her 8-year-old daughter has been day dreaming and not paying attention. After discussing with her GP, an EEG was organised and revealed a 3Hz spike waves. What medication is offered at this point?

Answer 10

Ethosuximide for absence seizure

Question 11

Which treatment can be used for psychosis in a patient with parkinson’s disease?

Answer 11

quetiapine

Question 12

What is the causative organism for meningitis with

gram‐positive, flagellated rods.

Answer 12

listeria

Question 13

An 18-year-old university student presents with stiff neck, photophobia and fever. Cultures revealed a gram-negative diplococcus.

What is the causative organism?

Answer 13

Neisseria Meningitidis

Question 14

A 3-year-old presents with signs of meningism. Culture revealed a gram‐negative coccobacillus. Prior to vaccination this was the most common cause of meningitis in children. What is it?

Answer 14

H. influenzae

Question 15

Who is risk of listeria meningitis?

Answer 15

Neonates
pregnant females
immunocompromised
elderly

Question 16

A stroke in what structure causes both motor and sensory symptoms?

Answer 16

internal capsule

Question 17

A defect in this structure causes full paralysis except blinking and eye movement.

Answer 17

basilar artery stroke –> locked in syndrome

Question 18

A 19-year-old man is hospitalized in a psychiatric ward after developing visual and auditory hallucinations. He has a seizure soon after being admitted and is transferred to the emergency room. He is postictal and noted to have a fever and meningism.

What is the most likely diagnosis?

Answer 18

herpes simplex encephalitis

Question 19

23, female presents to her GP with a 2 week history of bilateral leg weakness having started with pins and needles and numbness in her hands and feet. She has had a few days of urinary incontinence which has resolved. 2 years ago she had an episode of blurred vision and pain in the right eye which lasted a month and fully resolved.

What is the most likely diagnosis?

Answer 19

MS

Question 20

61 female becoming increasingly weak on her right side over a one week period. She is unable to walk and has slurred speech and right side of her face is drooping. Past history of breast cancer

o/e – right facial weakness, grade 4/5 weakness of the right arm and leg, right homonymous hemianopia and some difficulty naming objects and reflexes are brisk on the right side and her right plantar response is upgoing

What is the most likely diagnosis?

Answer 20

brain mets

Question 21

56 male with a 6 month history of progressive weakness of his right hand. Also had problems with swallowing and has choked whilst eating on several occasions

o/e he has wasting of his upper and lower limbs and some fasciculation’s were noted his right plantar was up going and his reflexes were generally brisk

What is the most likely diagnosis?

Answer 21

MND

Question 22

A 47 year man has an acute left hemiplegia and resolves in 60 minutes. His symptoms started abruptly. There is no associated headache. He is a heavy smoker.Clinical examination is normal. CT scan of head is normal.He is treated with aspirin. The medical team want to investigate the most likely cause of his symptoms.

Which is the most appropriate additional investigation? A. Cerebral angiography
B. Doppler ultrasound scan of carotid arteries
C. EEG
D. MR scan of brain
E. Repeat CT scan of head in 48 h

Answer 22

B. Doppler ultrasound scan of carotid arteries