QC LAB Flashcards
Used almost exclusively with alternative detection such as mass spectrometry.
Capillary columns
Which is not a possible sample material/s for IR Moisture Analyzer?
Gas
An instrument used to measure angle of rotation cause by passing of polarized light through and optically active substance.
Polarimeter
Which among the following physical properties is used in assessing the purity of a volatile oil?
Refractive index
A method of water determination which do not distinguish weight loss due to vaporization of water from other volatile compounds
Thermogravimetric
It is often used for determining the moisture content of drugs that have low water contents.
Oven Drying
Measurement of internal diameter is less than 0.3 mm.
Capillary columns
Which is (are) a part (s) of a HPLC apparatus?
I. HPLC pumping system
II. Chromatographic columns
III. Injector port
IV. Detectors (UV/ Vis)
I, II, III, IV
This is a simple way to check for the acidity/alkalinity of the sample and very useful when all you need is 0.2-0.5pH unit accuracy.
pH strip
Ca carbide method is classified as:
Chemical
It is used to observe both the total reflection borderline and the instrument’s internal measurement.
eyepiece
IR 35 moisture analyzer is classified as:
Thermogravimetric
In the formula of specific rotation, what is being measured in the “l”.
Sample tube
A binder is added to ensure that the stationary phase adheres firmly to the backing plate and does not flake off during the development.
True
A liquid/gas phase, maybe pure/mixture of liquids or a gas vapor; carries the sample.
Mobile phase
A compound that is capable of rotating a plane-polarized light is:
Optically active
A method of water determination in which the solid must dissolve in the titration medium to be sure that the total amount of moisture is released.
Chemical
Halogen drying is classified as what specific water/moisture determination method?
Thermogravimetric
Silica gel it is best suited to the analysis of acidic compounds and polar compounds such as amino acids and sugars.
True
A method of water determination which is applied to most systems with a moisture content of >0.1%
Thermogravimetric
Pans should be dried in an oven and stored in a desiccator prior to use.
True
A dextroratory optically active compound tend to rotate plane polarized light clockwise and correspond to a value that is;
Positivr
Type of column that is used to improved sensitivity and lower solvent consumption at the expense of loading capacity.
Low-ID columns
Which part of the polarimeter allows the entry of plane polarized light?
Polarizer
Azeotropic-toluene distillation is under what USP method of water determination.
Method II
A technique that is used to separate mixtures of substances into their components.
Chromatography
Which of the following is NOT a method used in determining moisture content?
Trituration method
For one-point calibration, this standard buffer solution can be used:
pH 7
Part of the HPLC that provide the higher pressure required to move the mobile phase and analyte through the densely packed column.
Pump
Detector setting of HPLC:
280 nm
A support for adsorbent layer in TLC plate must be an inert material. Which among the choices is not used as one?
Piece of wood
It is a bench-top device for the high-precision measurement of an index of refraction.
Refractometer
Measurement of internal diameter is 4.6mm.
Analytical scale columns
This method is applied to most systems with a moisture content of >0.1%.
Thermogravimetric
The hydrogen ion concentration may be expressed in terms of _____.
pH
Pans should be handled with forceps because fingerprints can contribute to the mass of a sample.
True
Involves the spotting of a sample of a mixture of components at one end of an adsorbent-coated glass plate followed by a passage of a solvent through the adsorbent for the purpose of separating the components of the sample.
Thin Layer chromatography
Measurement and interpretation of the polarization of transverse waves.
Polarimetry
When the direction of the rotation of optically active substance in polarimeter is towards the left, it is known as _
Levorotatory
Part of the refractometer that contains the measuring prism and acts as sample compartment.
lower prism
It is an instrument that is used to measure the humidity.
Electrolytic Hygrometer
An electronic device for potentiometric measurements
pH meter
In this instrument the liquid sample is sandwiched into a thin layer between an illuminating and refracting prism.
Abbe Refractometer
Scientific instrument used to measure the angle of rotation caused by passing polarized light through an optically active substance.
Polarimeter
Csaba Horvath was one of the pioneers of this instrument.
HPLC
olvent or solvent mixture is drawn up the plate via capillary action.
TLC
Crushing strength of tablets
Hardness tester
Thickness and diameter of tablets
Vernier caliper
Optical activity of sugars
Polarimeter
Index of refraction of volatile oils
Refractometer
Acidity and basicity of liquid pharmaceuticals
pH meter
Water content of excipients
Moisture analyzer
Amount of drug absorbed
Dissolution tester
Amount of acid radical impurities
UV-Vis spectrophotomer
Time to break tablets into smaller pieces
Disintegration tester
Abrasion to shock of tablets
Friabilator
stationary phase is a polymeric substance containing numerous pores of molecular dimensions.
Size Exclusion
stationary phase is liquid
Partition chromatography
stationary phase is a polymeric matrix on which functional group bonded.
Ion exchange
stationary phase is solid.
Adsorption chromatography
Sample: Aspirin 80 mg tablets
Specification = 90-110%
Concentration of Aspirin std = 0.020 mg/mL
Volume of sample taken = 15 μL Peak area of the standard = 685676 Peak area of the sample = 421232
Compute for the mg of Aspirin (2 dec places) = ?
81.91 mg
% Labeled claim = 102.39%
QC disposition (passed or failed): passed
Compute for the specific rotation:
50 grams of lactose dissolved in 100 mL distilled water & was put in a 100-mm polarimeter tube. The reading is 26.9203°.
Round off your answer in to 4 decimal places. Units must be in word.
53.8406 degrees
Compute for the observed angle of rotation (round off to 4 decimal places), Unit must be in word.
Given: [α]λT = - 29.3301° concentration = 30g dissolved in 100mL of distilled water
length of tube = 200mm
-17.5981 degrees
A 3,068 mg of Phenobarbital was dried in an oven at 150 degree Celcius. After 4 hours, the weight decreased to 46.68 grains. Compute for the % moisture content of Phenobarbital. What will be the QC disposition if the limit is not more than 7.0% of its weight.
Note: to achieve a uniform answer, convert mg to grains by using the whole number conversion, but the answer of the conversion must be in 4 decimal places. Recall the conversion introduce during your Pharmaceutical Calculation course.
1.10%
A 3,068 mg of Phenobarbital was dried in an oven at 150 degree Celcius. After 4 hours, the weight decreased to 46.68 grains. Compute for the % moisture content of Phenobarbital. What will be the QC disposition if the limit is not more than 7.0% of its weight.
PASSED
Compute for the pH and pOH of 0.0028M Nitric acid Note: round off both answers up to 4 decimal places.
pH 2.5528
pOH 11.4472
A 15 grams Hyoscine was weighed to make 50mL solution. It was placed in a 100mm sample tube. Compute for the observed angle of rotation of hyoscine if the specific rotation is +12.85 degrees.
3.855 degrees
The water content of Meropenem powder using 0.0123 grams sample was computed at 5.18%. If the volume of the reagent used reached 13.85m L, what is the water equivalence factor of the Karl Fischer reagent ?
0.046
A raw material sample of Rose oil was submitted to QC dept. for testing. The sample obtained an n27D reading (below) at 270C.
USP specification for Rose oil: N20D = according to the specifications given in your notes.
- Calculate the n20D of the oil.
- Based on the specifications previously given in your notes for
rose oil, does it conform with the USP specification? (passed/failed)
- = 1.4852
- FAILED
An acacia was placed in an oven and dried for one and a half hour. A 0.221 kgs final weight has resulted to a 0.95% moisture content. What is the initial weight (mg) of the excipient?
223119.64 mg
