QC

Question 1

a) Name of symmetric bell-shaped curve (healthy) and

b) non-symmetrical curve (diseased)

Answer 1

a) Gaussian

b) non-parametrical

Question 2

what is CV%, Equ, interpret. & ideal value (& exception)

Answer 2

how far SD (in %) is from mean.
Equ = (SD/Mean)*100
higher CV% = larger SD
*ideally should be <5% (but for Na it must be < 1%)

Question 3

define SD, Equ, Interpret. & ideal range

Answer 3

how far a point is from the mean
SD =
closer to mean (0) = better. If larger = further
ideal to have values w/in +- 2SD

Question 4

Find [unknown] w/ what equ.

Answer 4

( [Std] / AbsStd ) * AbsUnkn

Question 5

what are calibrators?

Answer 5

solutions with KNOWN [ ] => relationship b/w signal response vs analyte [ ]

Question 6

what are controls?

Answer 6

(3x) known [ ] of analyte > mointor precision & accuracy of assay & analyser

Question 7

Qcontrols have _x levels: _, _ & _

Answer 7

3x
low
normal
high

Question 8

Deifference b/w external QA/QC vs internal QC

Answer 8

EQA: Compares results of a lab w/ other labs - are using the same instrument / reagent = if their results are similar to others
Int. QC: monitors precision & accuracy of assay & analyser = if test results are close to std controls (measure accuracy)

Question 9

Levey-Jennings Chart, or

Westguard rules are used for measurement of __

Answer 9

control (QC measurment)

Question 10

what to do when there’s a problem in the control value?

Answer 10

• repeat the experiment
• check expiry dates
• check machine

Question 11

What is proficientcy testing?

Answer 11

• external quality assessment (EQA) / Ext. QC
• long term QC
• an independent assess. of analytical performance
• labs tests analyte samples in unknown duplicates = compares this w/ others