Qbank/MKSAP Flashcards
A patient has a blue toe 3 days following cardiac cath s/p MI. What is the most likely cause?
Dislodged atheroembolism during cath
Criteria of metabolic syndrome? (5)
Abdominal obesity- waist circumference > 40 in men, 35 in women Fasting glucose > 100 BP > 130/80 TGs > 150 HDL <50 in women
How does guillan barre cause respiratory failure? What is the best test to monitor?
Muscle weakness
Vital capacity
When should tpa be used in strokes? Contraindications?
Within 3 hours and CT shows no brain bleed
Contraindicated when- hx of stroke in past 3 months, hx of intracrial bleed, major surgery, MI, active bleed
Why is it important to remove clothing soaked in vomit due to an organophosphate poisoning?
transcutatneous absorption
What is different about vitamin D deficiency in adults compared to children?
Adults have defective bone mineralization
Children have defective bone AND cartilage mineralization
How do you definitively diagnose bronchiectasis?
High resolution CT scan
Which tests should be performed at the diagnosis of HTN? (4)
Urinanalysis
CMP
Lipid profile
EKG
A patient 2 months s/p MI comes in with persistent ST elevation and deep Q waves- what complication has occurred?
Ventricular aneurysms
Papillary muscle rupture typically occurs between 2 days a a week
A patient slaps his foot as it hits the ground while he walks- what vertebrae could be damaged?
L5 radiculopathy
Others causes include neuropathy and trauma
A patient has a dull hypomobile tympanic membrane and HIV- what is the cause?
Serous otitis media or non infectious effusion
A patient has X-ray showing expansile and eccentrically lytic area in epiphysis of distal femur- likely diagnosis?
Giant cell tumor- this is a soap bubble lesion
What restrctive lung disease is associated with a normal or increased FRC?
Ankylosing spondylitis- due to chest wall motion restriction
What are EPO levels in PV?
Low- the increase in RBC is EPO independent
What is the best treatment for acute rejection of a kidney transplant?
IV steroids regardless of cause
What is amaurosis fugax? What is it a warning since of?
Painless loss of vision due to emboli
Warning sign of a stroke
An anterior cerebral artery stroke has what deficits?
Contralateral motor deficits more pronounced in lower limb than upper limb
A middle cerebral artery stroke has what deficits?
Contralateral motor deficits more pronounced in upper limbs than lower limbs +/- aphasia
A middle aged woman presents with pruritis, jaundice, xanthelasmas and is positive for anti-mitochondrial antibodies- what is the best treatment? Diagnosis?
Ursodeoxycholic acid
Primary biliary cirrhosis
What are some manifestations of systemic sclerosis?
GERD, R heart failure, HTN, anti-topoisomerase antibodies, pulmonary fibrosis
What is the treatment for cat scratch disease?
Azithromycin for 5 days
How does sodium bicarbonate help with treatment of TCA overdose?
Alleviates depressive action on Na channels by increasing extracellular Na
Patient’s with suspected ACS should be administered what ASAP?
Aspirin, decreases mortality
Why would someone who received multiple units of pRBC have parasthesia?
Blood products can have large amounts of citrate which chelates Ca and causes hypocalemia
A patient has leukocytosis following an asthma exacerbation- why?
Probably received glucocorticoids which mobilize the marginal pool of neutrophils
A patient with HTN and a fib comes in with dry skin, weight gain, fatigue, and difficulty concentrating. What medication could be responsible?
Amiodarone- it is inducing hypothyroidism
Also look out for pulmonary fibrosis and hepatotoxicity
How do you treat pseudotumor cerebri?
LP to let out some of the pressure- until opening pressure < 20
What 3 organs are typically affected by GVH disease?
Liver, skin, intestine
What are some signs of drug induced interstitial nephritis?
acute renal failure, arthralgia, rash, and WBC casts of eosinophils
What are causes of atrial fibrillation?
HTN, valvular disease, hyperthyroid, drugs, pulmonary embolism, CHF
What is the best treatment for someone with EKG changes and hyperkalemia?
IV Ca gluconate
A patient undergoes a CABG procedure and requires 10 units of pRBC and develops hypotension during the procedure. He then develops jaundice on POD 3- why?
Post-op cholestasis
What is the SAAG?
Serum ascites albumin gradient- serum albumin - fluid albumin
> 1.1 is consistent w/ portal HTN
What vaccine should people over 65 get who already had pneumovax?
Varicella
What one time screening should be done in patients >65 who have 10 year pack history?
Abdominal ultrasound to rule out AAA
What is the treatment for acute cocaine intoxication?
BZDs
What medication has been proven to decrease the frequency of relapse with alcoholics?
Naltrexone
A patient with prostate cancer now has low back pain- best diagnostic test?
MRI of thoracolumbar spine to look for bony metastasis
How to diagnose and treat chronic cough NOT caused by GERD, allergic rhinitis, or asthma?
Inhaled albuterol trial- any response could mean eosinophilic bronchitis
Tx of chronic cough is antihistamines and decongestants
A patient has unsuccessfully tried to lose weight with diet and exercise for 3 years- what is the next step in treatment?
Try orlistat before surgery
What is a possible treatment for heavy menstrual bleeding?
medroxyprogesterone acetate
A woman with amenorrhea has a positive progestin challenge- menses occurred after progestin- diagnosis?
Chronic anovulation with estrogen present
What is the proper screening test for hearing impairment in the elderly?
Whisper test
What is be best treatment for disequilibrium causing falls in the elderly?
Physical therapy
A patient comes in with a BP of 162/100- what is the best treatment?
Stage 2 HTN needs 2 DRUGS- HCTZ and ACEI
What are some lung parameters seen in neuromuscular respiratory failure?
Normal FEV/FVC ratio
Increased RV
Low maximum respiratory pressures
A patient with systemic sclerosis has normal lung volumes but worsening dyspnea on exertion- what lung pathology could be occurring?
Pulmonary arterial HTN
What constitutes a complicated pleural effusion and what is the treatment?
pH < 7.2, glucose < 60, LDH > 1000
Treat w/ chest tube b/c will respond poorly to antibiotics
A patient has a lymphocyte dominated pleural effusion- next step in management?
Pleural biopsy for TB
A patient’s well controlled asthma becomes much worse following a URI- what is the best treatment?
Short dose of oral corticosteroids to help patient regain control of asthma
A patient is having a COPD exacerbation- what can reduce the need for intubation?
Noninvasive positive pressure ventilation
When is lung transplant considered in COPD?
PCO2 > 50 during hospitalization, FEV not > 20%, DLCO < 20%
A 65 year old woman has back pain, acute kidney injury, and hypercalcemia- diagnosis?
Think multiple myeloma until proven otherwise
Look for lytic lesions on X ray or Bence Jones protein in urine
A patient begins taking amitriptyline then comes to the ED with abdominal pain- what is happening and what is treatment?
Urinary retention due to anticholinergic effects of TCAs
Urinary cath is diagnostic and therapeutic
What is the initial treatment for agitation in the elderly?
Low dose haloperidol
A patient with hx of NSCLC has a new brain mass at gray-white matter junction- treatment?
Resect mass
Whole brain radiation
What is the treatment for inferior wall MI?
Fluid resuscitation to increase RV stroke volume
What will a right heart cath show in PE?
Increased RA pressure, increased pulmonary artery pressure, normal PCWP, RV dilatation
Which kidney disease is associated with HIV?
FSGS
A patient develops PNA after being intubated and is not responding to ceftriaxone- next step?
Zosyn to cover for pseudomonas
How do you treat someone with an area of erythema and induration that grows gram positive branching bacteria?
IV penicillin
What is the treatment for influenza?
Oseltamivir
Pleural effusion fluid has a very high amylase- what is the diagnosis?
Esophageal perforation
Look for subcutaneous emphysema, mediastinal widening
A patient with AML s/p bone marrow transplant has diarrhea and pneumonitis- diagnosis?
CMV infection most likely
What leads to edema in CHF?
Constriction of renal arterioles and renin angiotensin system activation
Both tacrolimus and cyclosporine cause nephrotoxicity- what is a side effect of cyclosporine that can help differentiate the two?
gum hypertrophy and hirtuism
What is the major toxicity of mucophenolate?
Bone marrow suppression
What is the major toxicity of azathioprine?
diarrhea, leukopenia, hepatotoxicity
A patient comes in with CML what show treatment focus on?
Targeting abnormal tyrosine kinase activity- imatinib is one choice
What is the pathophysiology behind carpal tunnel syndrome?
Deposition of mucopolysaccharide protein complexes
What is seen in hereditary spherocytosis with respect to MCHC and RDW and why?
Increased MCHC and RDW due to membrane loss and RBC dehydration
An HIV patient has a bright red firm friable nodule- diagnosis and treatment?
Bacillary angiomatosis
Treat with erothromycin
How can acute pancreatitis cause hypotension?
Intravascular volume loss due to increased capillary permeability
A patient with HIV comes in with pain swallowing and substernal burning? Diagnosis and treatment
Esophagitis, most likely from candida
Therefore, treat with fluconazole
Candida»> than CMV
What is the classic scenario of dequervian’s synovitis?
Newborn mother having pain when she lifts her infant from a crib
Finklestein test: Passive stretching of tendons by moving flexed thumb into the palm
What are 2 common side effects of EPO therapy?
Worsening of HTN
Headaches
A patient with a h/o radiation therapy presents with hepatomegaly, ascites and increased JVP- diagnosis?
Constrictive pericarditis
How can PCWP differentiate between cardiogenic and hypovolemic shock?
Will be high in cardiogenic shock and low in hypovolemic
What are some complications of acute pancreatitis?
Pleural effusion, ARDS, ileus, and renal failure
Typically caused by activation of pancreatic enzymes
How can nephrotic syndrome cause hypercoaguability?
Increased loss of pro-coagulation proteins due to proteinuria
A patient was recently discharged from the hospital after having hallucinations and now presents with muscle rigidity, mental status changes, fever, and diaphoresis- diagnosis?
Neuroleptic malignant syndrome- patient was most likely taking anti-psychotics which have dopamine antagonist effects causing NMS
What is first line treatment for chronic OA?
Tylenol
NSAIDs are for acute exacerbations
Nikolsky’s sign is associated with what disease?
Pemphigus vulgaris
What is the most common cause of nephrotic syndrome in patients with Hodgkin’s lymphoma?
Minimal change disease
FSGS can also occur
What effects can digitalis have on EKG and how?
Can cause atrial tachycardia and AV block
Caused by increased vagal tone and decreased conduction through AV node
What are some exacerbating and relieving factors in lumbar stenosis?
Exacerbated by narrowing of spinal canal via extension- standing and downhill walking
Relieved by widening of spinal canal via flexion- sitting and walking uphill
What is an effective treatment for fibromyalgia?
TCAs such as amitriptyline
A 70 year old woman has femoral bowing and hearing loss- diagnosis and pathophysiology?
Paget’s disease via osteoclast dysfunction
What can cause pain and tenderness over anteromedial tibia?
Anserine bursitis
Prepatellar bursitis causes swelling below patella
A 30 year old male has positive P-ANCA and bloody diarrhea. Also has painful erythematous nodules over his shins- diagnosis?
He has IBD- UC can be P-ANCA positive!
A patient following a major surgery requiring 10 units of RBC has hypotension and hyperbilirubinemia- diagnosis?
post-op cholestasis
How does portal HTN cause ascites?
Increased capillary hydrostatic pressure
A patient has isolated shoulder pain and a normal shoulder exam- next step?
CXR to look for etiology of referred shoulder pain
What is the best treatment for gout acute attacks?
NSAIDs
What is the best treatment for chronic gout?
Allipurinol and low dose colchicine
Give colchicine to avoid flare up after initiating uric acid lowering therapy
What is more diagnostic of rheumatoid arthritis- imaging or rheumatoid factor?
Imaging of bony or cartilage erosions more specific than rheumatoid factor
A patient with rheumatoid arthritis refuses to stop drinking two glasses of wine a day but needs medication beyond NSAIDs- what DMARDs should be avoided?
Methotrexate due to hepatotoxicity
A 30 year old man has rapid onset of psoriatic arthritis- what could be an underlying problem?
HIV can cause explosive onset psoriasis
What is the diagnostic criteria for SBP?
PMN count> 250 in ascites fluid
A patient without alcohol use presents with elevated lipase. U/S for gallstones are negative. He has crops of yellow papules on his arms- diagnosis?
Pancreatitis via hypertriglyceridemia- eruptive xanthomas on his arm
A patient presents four weeks after d/c for pancreatitis diagnosis with palpable abdominal mass and elevated lipase- diagnosis?
Pancreatic pseudocyst
A CT scan shows dilated central bronchi and thickened bronchial walls- diagnosis and most common complication?
Bronchiectasis
Can cause hemoptysis
What is the treatment for diabetic retinopathy with macular edema?
Photoanticoagulation
LDL goal for patient with 0 risk factors?
<190
How do you manage hypothyroid in pregnancy?
Monitor TSH levels- levo doses may need to be increased
What is the treatment for Graves disease?
Atenolol and methimazole
What diuretic can cause severe hyponatremia?
HCTZ
How can pancreatitis cause hypocalcemia?
Generation of free fatty acids chelate insoluble calcium salts resutling in hypocalcemia
A patient with rheumatoid arthritis has a ferritin of 50 on iron studies- what type of anemia?
Iron deficiency w/ anemia of chronic disease
Ferritin< 100 is suspicious for mixed anemia w/ iron deficiency
What is the best test for osteonecrosis when X ray is normal?
MRI»> radionuclide bone scan
What is the triad of TTP?
hemolytic anemia, thrombocytopenia, CNS symptoms
A patient prefers colon cancer screening by FOBT x3 annually. One is positive- what is next step?
Colonoscopy
A patient has a breast mass with BIRADs score of 2 on mammography?
US to see if fluid filled or solid mass
A man with a history of prostate cancer reports for check up. denies symptoms, but bone scan shows multiple metastases- best treatment?
Leuprolide- GnRH agonist
A patient with history of cancer and metastasis has moderate pain not controlled by NSAIDs- next step?
Short acting opioids first
Long acting are used once pain is controlled and dose is calculated
A patient with sepsis and a platelet count less than 30 should receive what treatment to improve mortality?
Protein C
A patient presents with acute prostatitis and does not respond to IV fluoroquinolones- next step?
Look for abscess- transrectal US
A pregnant woman has asymptomatic bacturia- next step?
Is the next step different for non-pregnant woman?
Pregnant- Amoxicillin! do NOT observe
Non-pregnant- Observe
What is standard outpatient treatment for women with pyelonephritis who are not pregnant?
FQ for 7-10 days
A 25 year old sexually active woman comes to the dr for a checkup. She has no symptoms but has not been to the drs for 3 years. What STD screening should be done?
HIV, G, C
Syphilis only if she is at risk
What is the best way to prevent ventilator associated pneumonia?
Semi-erect positioning of the patient- 45 degrees
A patient has N. meningitidis- next step in precautions?
Face mask- nasopharynx is the reservoir
A 66 year old patient presents for a check up. PMH significant for severe pneumonia 4 years ago where he was given pneumovax prior to discharge. Does he need pneumovax again?
Yes- should receive 2nd dose of vaccine 5 years after initial dose if initial dose < 65 years old
A patient has suspected vertebral osteomyelitis after getting MRI and X ray- what is next step?
Get blood cultures before antibiotics
Typically- ceftriaxone is good coverage EXCEPT for MRSA, hence blood cultures
A patient is going to the dentist…Prophylaxis?
Has a heart murmur without vegetations
Has a heart murmur with vegetations
Has a heart murmur with vegetations and allergic to penicillin
No vegetations means NO prophylaxis
Penicillin is 1st choice
If allergic- clindamycin
A patient presents with diarrhea and tenesmus within 6 weeks of radiation therapy- diagnosis and test?
Radiation proctitis- diagnose with flex sigmoidoscopy
What the treatment of salmonella causing bloody diarrhea
Supportive unless immunocompromised
How do you diagnose HUS?
Blood smear
What are the 2 most likely causes of painless rectal bleeding in elderly patients?
Diverticulosis and vascular ectasia
Anti smooth muscle antibodies are associated with what?
Autoimmune hepatitis
What is the triad of hypotension, clear lung fields, and elevated central venous pressure indicative of? Treatment?
R ventricular failure
Tx is normal saline
A patient with history of CAD and angina presents with increasing symptoms, still only with exercise. What is the next step?
Coronary angiography- no need for stress test
A patient has new onset heart failure, confirmed low EF by echo- what is the next step?
Coronary angiography to assess for potential revascularization
A sex worker presents with elevated transaminases and normal PT. On day 3 of hospitalization transaminases are decreasing but PT is markedly increased- what is happening?
Progression to fulminant liver failure- very few functioning hepatocytes
Without rising PT, could just be recovery from liver injury
What CBC finding is a poor prognostic indicator in CLL?
Thrombocytopenia
What side effect of Ca channel blockers could be mistaken for heart failure?
Edema
What is first line treatment for MALT lymphoma?
Treat H pylori first, then possibly chemotherapy
What are two signs that BPH should be evaluated further?
Increased Cr or abnormal UA- signs of kidney damage
Get renal US
A 30 year old patient presents with headaches and right sided renal bruit- best treatment?
Stent placement»_space;> medical management
What abnormal lab value is caused by lupus anti-coagulant but what is the clinical presentation?
Prolonged PTT
Presents with clots- miscarriages are common
What is terminal hematuria indicative of?
Prostae or bladder disease
What is the best medication for anorexia associated with cancer?
Progesterone analog»_space;» cannabanoids
A diabetic presents with foot pain and X ray shows loss of cartilage, osteophyte formation, and loose bodies- diagnosis?
This is charcot’s joint- due to nerve damage
What three veins form the most DVTs
Femoral, iliac, and popliteal
Rank the ways to lower BP by greatest effect: reduce alcohol intake, DASH diet, weight loss, exercise, decreased sodium intake?
Weight loss»DASH»exercise»Na restriction»alcohol
A smoker presents with a palpable neck lymph node positive for squamous carcinoma- next step?
Pan-endoscopy to find tumor
A patient presents with a malar rash, proximal muscle weakness causing difficulty rising from a chair- diagnosis?
Dermatomyositis- NOT SLE
DM associated with ovarian and breast cancer
Rheumatoid arthritis increases risk for what?
Osteoporosis
A 35 yo woman with chronic headaches presents with painless hematuria- diagnosis?
Analgesic nephropathy–> papillary necrosis
She is probably using a lot of NSAIDs
HIV drug side effect- didanosine?
Pancreatitis
HIV drug side effect- abacavir
Hypersensitivity
HIV drug side effect (drug class)- NRTIs
Lactic acidosis
HIV drug side effect- NNRTIs?
SJS
HIV drug side effect- nevirapine?
Liver failure
HIV drug side effect- indinavir?
Crystal induced nephropathy
How is MPGN different than other glomerulopathies?
Activation of complement in MPGN
Others are mostly immune complex mediated damage
What should be performed before starting trastuzumab?
Echocardiography
Cardiotoxicity
How can diabetic neuropathy cause urinary incontinence?
denervated bladder–> detrusor muscle weakness
Why are people with multiple myeloma at increased risk for infection?
Inability to produce functioning antibodies
A patient has a MI then 3 days later develops a cold leg–> next step?
Get Echo to look for LV thrombus
What is a particular extra-colonic tumor to look out for in Lynch syndrome?
Endometrial cancer in women
What is the treatment for stroke in a sickle cell patient (acutely)?
Exchange transfusion
What is the treatment for acetaminophen overdose if patient comes in 1 hour after ingestion (3 steps)?
Activated charcoal
Test levels at 4 hours
Decide if N-acetylcysteine is necessary
What part of the spine is most likely involved in RA?
Cervical spine
A patient with a recent URI comes in with symptoms of CHF- what will be seen on Echo?
Dilated ventricles w/ hypokinesia
Patient has virus induced dilated cardiomyopathy
What are two symptoms seen in mononucleosis NOT seen in strep pahryngitis?
Splenomegaly and cervical lymphadenopathy
What are patients with HIT more prone to- hemarthrosis or arterial thrombosis?
Thrombosis! Platelets are activated by antibody!
What are two risks of nephrotic syndrome unrelated to kidneys?
Accelerated atherosclerosis
Hypercoaguable
What is the most likely finding on renal biopsy in a patient with SLE and proteinuria?
Amyloidosis- deposits under polarized light
A patient with CKD is in EPO therapy for chronic anemia but not improving- what else can be done?
Iron supplement- EPO can use up iron stores quickly
What is the preferred antifungal treatment for histo?
Itraconazole»»fluconazole
What EKG finding is specific for pericarditis?
Electrical alternans- QRS complex amplitudes vary from beat to beat
What is pulsus paradoxus and what are 3 conditions where it is seen?
> 10mg drop in systolic blood pressure during inspiration
Tamponade, COPD, asthma
A patient with chronic HCV comes in with elevated ALT and detectable HCV RNA- treatment?
Interferon and ribavirin
What is the most rapid acting medicine to relieve dyspnea associated with cardiogenic pulmonary edema?
Nitroglycerin
Why would a patient taking benadryl have trouble urinating?
Anticholinergic effects causing detrusor inactivity
Why is sodium level important in heart failure?
Hyponatremia can signify worsening HF
What risk factor is most associated with AAA expansion and rupture?
Smoking!
Not HTN
A patient with COPD has new onset of clubbing in his fingernails- diagnosis?
Lung cancer
What are three commonly prescribed drugs that potentiate warfarin’s effects?
Acetaminophen, NSAIDs, amiodarone
Some antibiotics too
A patient has CAD and PAD and is resistant to a mutli-drug regimen for HTN- what other finding is likely?
Renal artery stenosis and abdominal bruit
What dictates the treatment in polymyalgia rheumatica? Will present with stiffness in neck, shoulders, and pelvic girdle.
Presence of giant cell arteritis means high dose prednisone
No GCA then low dose
What does a positive straight leg raise test signify?
Likely herniated disc
treat with NSAIDs and returning to normal activities
A patient with HSV meningitis develops renal failure in the hospital during treatment- why?
Crystalluria causing obstruction due to acyclovir
What response does pneumococcal vaccine produce?
B cell response independent of T cells
due to polysaccharide
What is the treatment for PVCs post MI?
NOTHING
Unless symptomatic- then beta blockers
A patient withe anemia has a hepatic venous thrombosis- what is the likely cause of anemia?
PNH is known for causing venous thrombosis
What nephrotic syndrome most commonly causes renal vein thrombosis?
Membranous glomerulonephritis
How do histamine blockers help with post-nasal drip?
Decrease secretions
A mobile mass in the lung with intermittent hemoptysis is indicative of what?
Aspergilloma
Which pneumonia causing bacteria can cause erythema multiforme?
Mycoplasma pneumo.
What is the treatment for uric acid stones?
Potassium citrate to alkalinize the urine
Hemochromatosis increases risk for what type of infection?
Listeria
What is the most frequent ectopic foci for A fib?
Pulmonary veins
A patient with metastatic prostate cancer to the bone has balance issues- what is the first step?
Give steroids in attempt to preserve neurologic function via reduced swelling
Imaging would be MRI
An HIV patient with bloody diarrhea gets a colonic biopsy showing cells with eosinophilic intranuclear and basophilic intracytoplasmic inclusions- diagnosis
CMV
What is the most common cause of death in acute MI
reentry arrhythmia
What mitral valve abnormality is seen with HOCM?
Anterior leaflet motion
A patient with cirrhosis wants to follow medical advice after years of drinking. He has a US of the liver and it shows no masses. What is next step?
Endoscopy to look for varices- major cause of morbidity and mortality
What is the treatment for TTP
Plasma exchange
An elderly patient with fatigue and lymphadenopathy has anemia- treatment?
Prednisone
Has NHL and autoimmune hemolytic anemia
If prednisone fails–> splenectomy
In RA, what causes a Baker’s cyst?
Inflamed synovium