QAS: Drug Therapies Protocol Flashcards
Oxygen: Metabolism
Nil
Oxygen: Indications
A wide range of conditions resulting (potentially) in systemic and/or localised hypoxia
Oxygen: Contraindications
Paraquat poisoning
Bleomycin therapy
Avoid Oxygen unless Pt is hypoxaemic (SpO2 > 88 %)
Oxygen: Side Effects
Hypoventilation in some COPD Pt with hypoxic drive
Drying of mucosal membranes
Oxygen: Presentations
Size C: 450 L Oxygen
Size D: 1600 L Oxygen
100% Oxygen should be administered for:
Intra-arrest
CO poisoning
Cyanide poisoning
Preoxygenation for RSI
Oxygen should be titrated to achieve an SpO2 of 88 - 92% for:
Paraquat toxicity Bleomycin treatment Obesity COPD Cystic fibrosis Neuromuscular disease
Oxygen should be titrated to achieve an SpO2 of 92- 96% for:
All other presentations
Oxygen: Driving accidents
Administer high-flow Oxygen
For Pts with COPD, a nebulised salbutamol must be delivered via nebuliser mask at a rate of:
6 L/minute
8 L/ minute for all other Pts
Methoxyflurane: Drug Class
Analgesic
Methoxyflurane: Pharmacology
Volatile, self-administered inhalation analgesic
Short-term pain relief
Greater propensity to diffuse into fatty tissue
Methoxyflurane: Metabolism
By the liver
Excreted by the lungs
Methoxyflurane: Indications
Pain
Methoxyflurane: Contraindications
Allergy/adverse drug reaction
Pts < 1 year old
History of significant liver/renal disease
History of malignant hyperthermia
Methoxyflurane: Precautions
ALOC
Intoxicated
Methoxyflurane: Side Effects
ALOC
Cough
Renal/hepatic failure
Methoxyflurane: Presentation
3 mL bottle
Methoxyflurane: Onset and Duration
Onset @ 1 - 3 minutes
Duration @ 5 - 10 minutes
Methoxyflurane: Schedule
Schedule 4 (Restricted drugs)
Methoxyflurane: Adult Doses
3 mL
Repeated once after 20 minutes
Total max. dose = 6 mL
Methoxyflurane: Paediatric Doses
3 mL
Single dose only
Deep sedation has been identified with methoxyflurane administration in Pts < 5 years. T/F?
True
Methoxyflurane: Total weekly dose should not exceed:
15 mL
Administration on consecutive days not recommended
Paracetamol: Drug Class
Analgesic
Antipyretic
Paracetamol: Pharmacology
Aminophenol derivative
Exhibits analgesic and antipyretic properties
No significant anti-inflammatory activity
Paracetamol: Metabolism
By the liver
Excreted by kidneys
Paracetamol: Indications
Mild to moderate pain
Fever (causing distress)
Paracetamol: Contraindications
Allergy/adverse drug reaction
Pts < 1 month old
Paracetamol: Precautions
Hepatic dysfunction Soluble tablets (sodium restriction)
Paracetamol: Side Effects
Nausea
Paracetamol: Presentation
Tablet: 500 mg
Elixir: 120 mg / 5 mL
Soluble tablet: 250 mg
Paracetamol: Onset and Duration
Onset @ 10 - 60 minutes
Duration @ 4 hours
Paracetamol: Schedule
Schedule 2 (therapeutic poisons)
Paracetamol: Route
PO = per oral
Paracetamol: Adult Dosage
Mild to moderate pain
Fever (causing distress).
> 16 years old: 0.5 g - 1 g
Presentation: tablet
Repeated every 4 hours
Total max dose in 24 hours: 4 g
Paracetamol: Paediatric Dosage
Mild to moderate pain
Fever (causing distress).
> 1 month old: 15 mg/kg
Presentation: elixir
Single dose only
> 7 years old: 15 mg/kg
Presentation: soluble tablet
Single dose only
Ibuprofen: Drug Class
NSAID: Non-steroidal anti-inflammatory drug
Ibuprofen: Pharmacology
Non-selective NSAID
Inhibits synthesis of prostaglandins
Provides an analgesic, antipyretic, and anti-inflammatory response
Ibuprofen: Metabolism
Metabolised by the liver
Excreted by the kidneys
Ibuprofen: Indications
Moderate pain due to acute inflammation and tissue injury
Ibuprofen: Contraindicationa
Allergy/adverse drug reaction to any NSAID or aspirin Current GI bleeding/peptic ulcers Dehydration or hypovolaemia Renal impairment NSAID-induced asthma Heart failure Pregnancy Angiotension converting enzyme (ACE) inhibitors Angiotensin II receptor blocker (ARBs) Pt < 13 years old Pt > 65 years old Coagulant medications Diuretic treatment
Ibuprofen: Precautions
Asthma
Hepatic dysfunction
History of GI bleeding/peptic ulcers
Ibuprofen: Side Effects
Nausea
Dyspepsia
GI bleeding
Dizziness
Ibuprofen: Presentation
Tablet, 200 mg
Ibuprofen: Onset and Duration
Onset @ 15 minutes
Duration @ 4 - 6 hours
Ibuprofen: Schedule
Schedule 2 (therapeutic poisons)
Ibuprofen: Route
PO = per oral
Ibuprofen may be used in conjuction with:
Paracetamol
Ibuprofen: Adult Doses
Moderate pain due to acute inflammation and tissue injury
Tablet per oral (200 - 400mg)
Must not be administered within 6 hours of previous ibuprofen administration
Ibuprofen: Paediatric Doses
QAS are not authorised to administer ibuprofen to paediatric Pts