Q4 2024 Deck Updates_Part 1

Question 1

What is the total number of products in the Prostate Cancer Imaging Landscape?

Answer 1

36 products

This includes various types of PET/CT agents and targeted agents.

Question 2

How many PSMA-targeted products are in the Prostate Cancer Imaging Landscape?

Answer 2

29 products

PSMA refers to Prostate-Specific Membrane Antigen.

Question 3

What types of PET agents are included in the Prostate Cancer Imaging Landscape?

Answer 3

PET/CT agents:
* Ga-68 (13)
* F-18 (9)
* Cu-64 (6)
* GRPR-targeted PET agents (4)
* non-PSMA/non-GRPR targeted PET agents (3)

Ga-68 and F-18 are commonly used isotopes in PET imaging.

Question 4

How many total products are in the Prostate Cancer Radiotherapeutics & PSMA-Targeting Therapeutics Landscape?

Answer 4

81 products

This includes various categories of radiopharmaceuticals and therapies.

Question 5

What are the different types of PSMA-targeted products in the Prostate Cancer Radiotherapeutics Landscape?

Answer 5

PSMA-targeted products:
* 68 PSMA-targeted
* 25 alpha-emitting radiopharmaceuticals
* 23 beta-emitting radiopharmaceuticals
* 8 immune cell therapies
* 8 bispecific T cell engagers
* 9 PSMA-targeted drug conjugates
* 8 non-PSMA/non-GRPR-targeted RLT
* 4 GRPR-targeted RLT
* 5 radioisotope undisclosed
* 3 Auger emitters/Tb-161

RLT stands for radioligand therapy.

Question 6

What is the number of products in the mCRPC Therapeutics Landscape?

Answer 6

87 products

mCRPC stands for metastatic Castration-Resistant Prostate Cancer.

Question 7

List the types of products included in the mCRPC Therapeutics Landscape.

Answer 7

mCRPC products:
* 21 androgen receptor pathway inhibitors
* 13 immunotherapies
* 12 DNA repair inhibitors (e.g., PARPi)
* 9 kinase inhibitors
* 6 antibody-drug conjugates
* 4 chemotherapy agents
* 3 bromodomain inhibitors
* 19 various other classes/MOAs

PARPi refers to Poly (ADP-ribose) polymerase inhibitors.

Question 8

Which companies are highlighted for deeper dives?

Answer 8

Key companies:
* Telix Pharma
* Blue Earth
* POINT Biopharma
* Curium
* Novartis
* Clarity Pharma
* ABX
* Fusion Pharma
* Janux Therapeutics

These companies are involved in the development of imaging and therapeutic products for prostate cancer.