Q 1-10

Question 1

ATROPINE POISONING

Answer 1

Pharmacological actions of atropine :
1. cvs - TACHYCARDIA due to blockage of m2 receptors on sa node
2. bp- no direct effect on bp
3. relaxes all visceral smooth nerves that recieve para sympathetic motor innervation

• may lead to constipation due to slowed passage of chyme
  *causes bronchodialation , espesially in COPD and Asthma
  *rise in body temp

Question 2

epinephrine is not prescribed when ?

Answer 2

when the patient is taking
*tricyclic antidepressants
*monoamine oxidase inhibitors

Question 3

metronidazole

Answer 3

it is an antibiotic given mainly against anaerobic bacteria and does not affect aroebic bacteria
<clostridium perfranins , helico bacter pylori , peptoocci , spirochetes >

Question 4

teratogenicity

Answer 4

capacity of drug to cause fetal malformation / abnormalities when administered to a pregnant woman

Question 5

classifiation of nsaids

Answer 5

1. NON SELECTIVE:
   a) Salicylates (aprin)
   b) pyrazolone derivatives (phenylbutazone)
   c) indole derivatives (indomethacin)
   d) propionic acid derivatives (ibuprofen)
   e) anthranilic acid derivatives (mephenamic acid)
   f) aryl-acetic acid derivative ( diclofenac)
   g) oxicam derivatives (piroxicam)
   h) pyrrolo pyrrole derivative (ketorolac)
2. PREFERENTIAL COX-2 INHIBITORS :
   *nimesulide
3. SELECTIVE COX-2 INHIBITORS:
   *celecoxib
   *rofe coxib
   *valde coxib
4. ANALGESIC : antipyretics with poor anti inflammatory action
   *PCM <paracetamol> (acetaminophen)</paracetamol>

Question 6

DIGOXIN

Answer 6

Patient should avoid food products that cause drug food interactions such as :
*chocolate
*spinach
*cereal greains
*nuts

Question 7

MYOCRDIAL INFARCTION

Answer 7

in a patient with suspected MI 2 drug given are :
*asprin
*clopidogrel

Question 8

NSAID block ?

Answer 8

endogenous prostaglandin synthesis through inhibition of cyclooxygenase enzymatic activity

Question 9

penicillin v has what better therapeautic effect over penicillin g

Answer 9

acid resistance and better oral absorption

Question 10

nifedipine causes ?

Answer 10

hyperplastic gingiva