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Biochem Q3 > Pyrimidine Nucleotides > Flashcards

Pyrimidine Nucleotides Flashcards

1
Q

What does Carbomyl phosphate synthetase II (CPSII) do?

A

Converts Glutamine –> Carbamoyl phosphate

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2
Q

What activates and inhibits CPSII?

A

Activate: ATP & PRPP
Inhibit: UTP

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3
Q

What is Ribonucleotide Reductase?

A

Ribonucleotide diphosphate (NDPs) —> Deoxyribonucleotide Diphosphate (dNDPs)

This enzyme maintains a balanced supply of dNTPs used for DNA synthesis

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4
Q

What regulates Ribonucleotide Reductase?

A

Activates: ATP
Inhibits: dATP inhibits

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5
Q

What is Adenosine Deaminase (ADA) deficiency ?

A

Occurs when Conversion of Adenosine to Inosine is blocked. Leads to an increase in cellular adenosine and dATP.

Ribonucleotide Reducatase is inhibited. Causes SCID due to T and B cell dysfunction

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6
Q

What does Thymidylate Synthase do?

A

Converts dUMP to DTMP

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Biochem Q3 (7 decks)

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