Pyrimidine Metabolism - Exam 1 Flashcards
1
Q
megaloblastic anemia
A
don’t forget to check B12 and folate
2
Q
carbon sources
A
3 aspartate
1 carbamoyl-P
3
Q
Nitrogen Sources
A
1 aspartate
1 carbamoyl-P
4
Q
orotic aciduria
A
low activity in UMP synthase tx uridine (UTP) - feedback inhibition
or OTC
5
Q
a defect in what urea cycle enzyme will lead to orotic aciduria?
A
Ornithine Transcarbamoylase
OTC
has high Ammonia!!
6
Q
Thymidine Kinase levels
A
relate to proliferation state of the cell and is highest as it enters the S phase… think cancer
7
Q
Hereditary Orotic Aciduria
A
loss of function in UMP synthetase
severe anemia and growth retardation
VERY RARE!!
feed uridine
8
Q
hyperammonemia s/s
A
think neurological
