Pyrexia of Unknown Origin

Question 1

Definition of pyrexia of unknown origin

Answer 1

If no diagnosis after:
3 outpatient visits
3 days in hospital
one week of outpatient investigation

Question 2

Types of PUO (4)

Answer 2

1. Classical
2. Nosocomial - develops in hospital, undiagnosed after 3 days
3. Neutropenic - undiagnosed fevel with neutrophils <500
4. HIV-associated - more than 3 days in inpatient, 4 weeks in outpatient

Question 3

What can cause PUO?

Answer 3

Infection, malignancy, inflammation