Pumps #2

Question 1

Structure of P-type ATPases - Region B

Answer 1

induces conformational changes in ion binding site

Question 2

Structure of P-type ATPases - Region C

Answer 2

phosphorylation site and nucleotide binding site

Question 3

Structure of P-type ATPases - Region J

Answer 3

comprises a hinge to allow cytosolic regions to move and interact

Question 4

CPx pumps

Answer 4

~ transport toxic and nutrient metals

~ found in animals, plants, fungi and bacteria

Question 5

Menkes disease

Answer 5

systemic copper deficiency

Question 6

Wilsons disease

Answer 6

excessive copper accumulation in the liver

Question 7

V-type pump - structure/function

Answer 7

~ Multiple transmembrane and cytosolic subunits

~ Establishes H+ electrochemical gradients.

Question 8

V-type pump - location

Answer 8

vacuolar
lysosome
synaptic vesicles

Question 9

ABC-type pump - structure/function

Answer 9

~ 2 sections of transmembrane spanning domains
~ 2 ATP binding domains
~ Range of physiological functions

Question 10

ABC-type pump - location

Answer 10

all membrane types

Question 11

ABC meaning

Answer 11

ATP Binding Cassette

Question 12

P-type pump - location

Answer 12

PM, SR or ER