Pulmonary Emergencies 2 Flashcards
Acute pulmonary edema: presentation
10
- Dyspnea
- Frothy pink sputum
- Pedal edema
- Ascites
- Rales
- Wheezing
- Hypertension
- Hypoxemia
- Restlessness
- Tachycardia
Acute pulmonary edema
etiology? 3
- From cardiogenic and noncardiogenic sources
- From sudden increase in left sided intracardiac filling pressures
- OR increased alveolar capillary membrane permeability
Cardiogenic pulmonary edema
Acute cases? 5
- Ischemia
- Acute severe mitral regurgitation
- Acute aortic regurgitation
- Hypertensive crisis secondary to bilateral renal artery stenosis
- Stress induced cardiomyopathy
Cardiogenic pulmonary edema
Chronic causes? 4
- Decompensated systolic CHF
- Decompensated diastolic CHF
- LVOT (left ventricular outflow tract) obstruction
- Valvular heart disease
Noncardiogenic pulmonary edema
- MAJOR CAUSE?
- Other causes? 7
- Major cause is acute respiratory distress syndrome (ARDS)
- Altitude
- Neurogenic
- Narcotic overdose
- Pulmonary embolism
- Eclampsia
- Transfusion related injury
- Salicylate overdose
Etiology of ARDS
10
- Sepsis
- Acute pulmonary infection
- Trauma
- Inhaled toxins
- DIC
- Shock lung
- Freebase cocaine smoking
- Post CABG
- Inhalation of high concentrations of O2
- Acute radiation pneumonitis
Acute pulmonary edema: treatment
Cardiogenic
O2 plus:? 4
Noncardiogenic
O2 plus:? 3
- Treat underlying cause
- Ischemia – Rx: nitrates, morphine, diuretics
- Valvular disease – diuretics
- Treat arrhythmias – ACLS protocol and diuretics
- Treat underlying cause
- If ARDS likely will need intubation and mechanical ventilation with PEEP (positive end expiratory pressure)
- Diuretics may be somewhat helpful
Acute pulmonary edema: treatment
4
- Assess the airway and the stability of the patient
Do they need to be intubated right away or can they be watched closely while diuretics are given? - Furosemide (Lasix) 40-80 mg IV….only if hemodynamically stable
- Supplemental O2
- Then target treatment tailored to the underlying cause
Aspiration:
1. Massive aspiration requires immediate what?
- Once intubated can then do what?
- Treat underlying cause such as? 2
- protection of the airway from further injury by intubation
- lavage and suction the lower airway
- Prolonged BVM during CPR
- Neurologic compromise secondary to stroke, SAH, head injuries etc.
Asthma: pathophysiology?
INFLAMMATION of the airways with an abnormal accumulation of eosinophils, lymphocytes, mast cells, macrophages, dendritic cells and myofibroblasts.
Asthma: pathophysiology:
Reduction in airway diameter caused by what? 4
- smooth muscle contraction,
- vascular congestion,
- bronchial wall edema, and
- thick secretions.
Acute asthma: assessment
- Beware of? 7
- Impending respiratory failure? 4
- Beware of :
- use of accessory muscles of respiration,
- fragmented speech,
- orthopnea,
- diaphoresis,
- agitation,
- low blood pressure (consider anaphylaxis),
- severe symptoms that fail to improve with initial treatment - Impending respiratory failure:
- inability to maintain respiratory effort and rate,
- cyanosis,
- depressed mental status,
- severe hypoxemia (SpO2 ≤ 95% despite high flow O2 by nonrebreather)
Acute asthma: assessment
6
- Measure peak flow if able
- Supplemental O2
- ABGs are generally not useful initially
- CXR generally not useful initially
- Establish IV access
- Frequent reassessment to determine if intubation and mechanical ventilation is needed
Acute asthma: peak flow
- Helps give an objective measurement as to the what?
- Peak flow less then ____ % of predicted = severe
- Measure before and after each what?
- severity of airflow obstruction
- 40
- nebulizer or MDI treatment.
Acute asthma: medical therapy
- Albuterol (inhaled beta 2 agonist)
- Ipratropium bromide (atrovent) (anticholinergic)
- Give with the albuterol (Duoneb) - Methylprednisolone (Solu Medrol)
- Magnesium sulfate
- Epinephrine
- Terbutaline
What do the following do for acute asthma:
- Albuterol (inhaled beta 2 agonist)?
- Ipratropium bromide (atrovent) (anticholinergic)?
- Give with the albuterol (Duoneb) - Methylprednisolone (Solu Medrol)?
- Magnesium sulfate?
- Epinephrine?
- Terbutaline?
- Bronchodilator
- Bronchodilator
- Glucocorticoid. Decreases airway inflammation
- For life threatening exacerbations that remain severe after 1 h of intense bronchodilator therapy
- For suspected anaphylactic reaction or unable to use inhaled bronchodilators
- For severe asthma unresponsive to standard therapies
COPD exacerbation
1. Most often precipitated by what?
- Increase or change in character of usual symptoms of what? 2
- DDx? 4
- a viral or bacterial infection
- dyspnea,
- cough or sputum production.
- CHF,
- PE,
- pneumonia,
- pneumothorax
COPD exacerbation: work up
5
- O2 sats
- ABG in severe exacerbations
- CXR to assess for signs of pneumonia, acute heart failure, pneumothorax
- Labs
- EKG
COPD exacerbation: work up
LABS? 3
- CBC,
- BMP,
- BNP (B-type Natriuretic Peptide) +/-
COPD exacerbation: Pharmacotherapy
4
- Supplemental O2 to maintain sats ≥ 90%.
- Solumedrol (methylprednisolone) 60mg IV
- Antibiotics to treat a respiratory source of infection and to include pseudomonas coverage
- Ex: Levaquin 750mg IV - Inhaled bronchodilators
- Albuterol 2.5mg AND Atrovent 0.05 mg via nebulizer (Duoneb)
COPD exacerbation: Treatment
1. Consider hospital admission if? 4
- If impending respiratory failure?
- Consider hospital admission if
- Symptoms are severe enough to prevent the patient from doing basic functions like sleeping, preparing meals or walking to the bathroom
- Failure to respond to initial therapy
- High risk comorbidities like pneumonia, CHF, arrhythmia, liver failure, kidney failure or DM
- Worsening hypoxemia - If impending respiratory failure:
- Intubation vs. NIPPV
Pulmonary embolism
- What is it?
- Severity?
- Forms? 2
- Obstruction of the pulmonary artery or branches with clot, tumor, air or fat
- Common and often fatal disease
- Can be acute or chronic
Pulmonary embolism: Signs and Symptoms
11
- Dyspnea
- Tachypnea
- Cough
- Hemoptysis
- Syncope
- Lower extremity edema
- Cyanosis
- Diaphoresis
- Hypotension
- May have rales on exam
- Lower extremity pain or erythema
Pulmonary embolism: Risk factors
12
- Pregnancy
- Obesity
- Prolonged immobilization
- Hormones: BCP’s, HRT, SERMs
- Cancer
- Trauma
- Recent joint replacement surgery
- History of DVT
- Autoimmune disease
- HTN
- Smoking
- CHF
Pulmonary embolism: work up
8
- CTA of the chest with PE protocol
- CXR
- EKG
- Echo +/-
- V/Q scan?
- D-Dimer?
- Doppler US of the LE
- Pulmonary angiogram is the OLD “gold standard”
Pulmonary embolism: Radiographic findings
3
- Hampton’s Hump
- CT with pulmonary infarction
- PE: Saddle embolism
EKG findings: PE? 3
- S waves in lead II
- Q waves in lead III
- Inverted T waves in lead III
Acute PE: Treatment/stabilize? 3
- Supplemental O2
If hypotension - Fluid bolus of 500 to 1000 ml NS
- Vasopressors
Vasopressors used to stabilize Acute PE? 4
- Norepinephrine,
- Dopamine,
- epinephrine,
- dobutamine + norepinephrine
Acute PE: treatment for anticoagulation
1. Unfractionated Heparin (UFH) use in who?
- Low Molecular Weight Heparin (LMWH) Prefered over UFH. Which drugs are these? 2
- Fondaparinux? Which drug? Give to which pts?
- use in unstable patients in case you need to stop anticoagulation and trial thrombolytics
- Enoxaparin (Lovenox)
- Dalteparin (Fragmin)
- Arixtra
- Give if patient has a history of allergy to Heparin or history of heparin induced thrombocytopenia…HITT
Acute PE: treatment
1. A vitamin K agonist such as warfarin should be started when?
- Continue with Lovenox until INR is ___?
- When to use thrombolytics?
- on the same day as anticoagulant therapy
- 2.0
- Patients with acute PE associated with hypotension needing vasopressor support or o/w hemodynamically unstable (“massive PE”) who do not have a high bleeding risk
Pneumonia: signs & symptoms
12
- Cough
- Fever
- Chills
- Pleuritic chest pain
- Dyspnea
- Sputum production
- Mental status changes
- GI symptoms (N/V/D)
- Tachypnea
- Tachycardia
- Hypoxia
- Rales, rhonchi or decreased in area of consolidation
Pneumonia: work up
5
- PA and lateral CXR
- CBC, CMP
- Blood cultures*
- Sputum for gram stain and culture*
- Pneumococcal and Legionella urine antibody tests*
Pneumonia:
Indications for admission can be based on a wide variety of objective data? 5
- SpO2 less than 92%,
- Febrile less than 35 C or > 40C
- RR >/= 30,
- tachycardia >/= 125,
- low SBP less than 90 mmHg
Pneumonia: treatment
7
- Supplemental O2
- Intubation or NiPPV if impending respiratory failure
- Antibiotics to target the most likely pathogen
- Fluids for dehydration or hypotension
- Antipyretics
- Albuterol nebulizer treatments +/-
- Incentive spirometry
Pneumonia: pathogens
1. Most likely pathogen is ?
- Patients requiring hospital admission (non-ICU)… Common pathogens besides S. pneumoniae? 5
- Streptococcus pneumoniae
- Patients requiring hospital
admission (non-ICU)… Common pathogens besides S. pneumoniae:
- respiratory viruses (influenza, respiratory syncytial virus, parainfluenza)
- M. pneumoniae
- H. influenza
- C. pneumoniae
- Legionella
Pneumonia: Abx (non-ICU)
3
- Respiratory fluroroquinolone (levofloxacin, moxifloxacin, gemifloxacin) ex: Levaquin (levoflaxacin) 750mg IV or PO qd
OR - Antipneumococcal beta-lactam (cefotaxime, ceftriaxone, or ampicillin-sulbactam) ex: Rocephin (ceftriaxone) 1g IV qd
PLUS - Macrolide (azithromycin, clarithromycin, or erythromycin) ex: Zithromax (azithromycin) 500mg PO or IV qd
Pneumonia: Pathogens
Hospitalized patients requiring ICU?
5
- S. pneumoniae,
- Legionella,
- gram-negative bacilli,
- Staphylococcus aureus and
- consider MRSA
Pneumonia: Abx (ICU)
Last slide! 3
- Antipneumococcal beta-lactam (cefotaxime, ceftriaxone, or ampicillin-sulbactam) PLUS azithromycin
OR - Antipneumococcal beta-lactam (cefotaxime, ceftriaxone, or ampicillin-sulbactam) PLUS a respiratory fluoroquinolone (moxifloxacin, gemifloxacin, or levofloxacin)
OR - For penicillin allergy: Respiratory fluoroquinolone PLUS aztreonam