Pulmonary Arterial HTN + Cardiology 4% Flashcards
What are the 3 endothelin receptor antagonists used for PAH?
- Letaris (ambrisentan)
- Tracleer (bosantan)
- Opsumit (macitentan)
What are the two PDE 5 inhibitors used for PAH?
- Revatio (sildenafil)
- Adcirca (tadalafil)
What are the 3 prostacyclin analogues used for PAH?
- treprostinil
- Orenitram®
- Tyvaso®
- Remodulin®
- iloprost (Ventavis®)
- epoprostanol (Flolan®)
What is the selective IP receptor agonist that is supplied in tabs that are multiples of 200mcg?
Uptravi® (selexipag)
What is the soluble guanine cyclase modulator used in PAH, and how is it supplied?
Adempas® (riociquat) comes in tabs of 0.5mg, 1mg, 1.5mg. 2mg and 2.5mg
Which medications for PAH are administered IV?
- Flolan® (epoprostanol)
- Revatio® (sildenafil)
- Orenitram® (treprostanil)
- Remodulin® (treprostanil)
Which PAH medications are supplied for inhalation?
- Tyvaso® (treprostinil), QID
- Ventavis® (iloprost), 6-9 times a day
Which PAH medications can be administered subcutaneously?
- Orenitram® (treprostinil)
- Remodulin® (treprostinil)
How is PAH treatment monitored in practice?
- 6 minute walk test
- goal in PAH is 440m or improvement from baseline
- Assessment of symptoms and/or side effects for dosing
What are the 5 WHO groups to classify PH?
- GRP 1: arteries in the lungs are narrow and stiff (true PAH)
- GRP 2: left heart disease leading to PAH (largest group)
- GRP 3: PAH due to chronic lung disease and hypoxia
- GRP 4: thromboembolitic PH (CTEPH)
- GRP 5: secondary PH (sarcoidosis, sickle cell anemia, chronic hemolitic anemia, splenectomy, ect)
What are the 2 specialty medications used to treat hypercholesterolimia?
- Praluent®
- Repatha®
Which medication comes as a single-use on-body infusor with prefilled cartridge?
Repatha®, and it delivers the medication subcutanously, via a 29G needle over 9 minutes.
Which specialty medication is indicated to reduce HF in patients with symptomatic NYHA Class II-III and LVEF<35%?
Corlanor® 2.5-5mg BID with meals
