Pulmonary administration 4 Flashcards
what are nasal preparations?
Many for topical activity on nasal mucosa
give some examples of topical activity on nasal mucosa
decongestants, antibiotics, antihistamines
how are they administered?
solution form
sprays or droplets
what are the limitations to nasal delivery - 4 points
a lot of the drugs not absorbed
may cause nasal irritation
some drugs undergo nasal metabolism
no aqueous solubility - can cause a problem
does the nasal cavity have a large volume and S.A.
yes
where is the olfactory region found in the nasal cavity
top of cavity
how is the cavity divided
by the nasal septum
divided diagonally
what are name of the three folds on nasal septum wall
superior, middle and inferior turbinates
where is the removal via?
via nasal hairs
how does further deposition in the nose occur?
via inertial impaction
what is the optimum particle size for nasal deposition
10 um
what is the main site for deposition and absorption
respiratory epithelium
which cells secrete mucus
goblet and basal cells
are the columnar cells ciliated?
yes
where are foreign materials trapped in
viscous mucus
