Pulmonary Flashcards
Normal pleural fluid function and composition
Normal function: provide smooth surface that reduces friction as pleura (visceral and parietal) move across each other
Normal composition: 1-10mL. Ultrafiltrate of plasma. NO protein (<1-2g), almost no WBC (<1,000), glucose similar to plasma and LDH < 50% of plasma
Factors affecting interstitial fluid formation
Force #1: Hydrostatic pressure (pushing force)
Force #2: Oncotic pressure (pulling force)
Pleural Effusion definition
Abnormally large collection of fluid in the pleural cavity - usually an indicator of a pathologic process/manifestation of an underlying disease
Clinical presentation pleural effusion
Often ASYMPTOMATIC
- SOB
- Cough
- Pleuritic chest pain
If caused by CHF, then LE edema in combo with above
IF caused by Tb/CA then night sweats, fever, weight loss in combo with above
PE Findings pleural effusion
Decreased tactile fremitus Decreased breath sounds Dullness to percussion Egophany (E --> A) \+/- pleural friction rub
Exudative effusion vs transudative effusion
Exudative: 2/2 increased vascular permeability (infection (acute-empyema, chronic-Tb), inflammation (SLE/RA), malignancy) - contains increased plasma proteins, WBCs, platelets
Transudative: Due to increased hydrostatic pressure (CHF) or decreased oncotic pressure (nephrotic syndrome, liver cirrhosis/failure, atelectasis
Light’s Criteria
Fluid is exudative if > 1 of the following criteria are met:
- Ratio of pleural fluid LDH: serum LDH >0.6
- Pleural fluid LDH > 2/3 upper limit of reference range for serum LDH
- Ratio of pleural fluid protein : serum protein >0.5
4 Types of fluid that accumulate in pleural space
- Serous fluid = hydrothorax
- Chyle = chylothorax (lymph fluid w/ TB & fat)
- Blood = hemothorax
- Pus = empyema (infected pleural cavity)
Pleural fluid analysis (3 items always analyzed)
- Protein
- LDH
- Specific gravity (<1.015 = transudative)
MCC Exudative effusion
Malignancy
MCC Transudative effusion
CHF
Empyema definition and etiology
Infection of the pleural space causing a pus-filled pleural effusion
Etiology
- Complication of PNA where bac escape to pleural space
- Penetrating trauma
- Complication of surgery, thoracentesis, chest tube
Fluid analysis of empyema
Grossly purulent fluid (pus-like) pH level <7.2 WBC >50,000 Glucose <60mg/dL LDH > 1,000 IU/mL
Treatment empyema
DRAINAGE (thoracentesis) & ABX vs…
VATs thoracoscopy with tube drainage vs…
Clagett window (open drainage of empyema cavity)
Pathophysiology, etiology, treatmentof malignancy pleural effusion
BFTP: Malignancy = MCC exudative pleural effusion
Patho: CA = inc capillary permeability, disruption of capillary endothelium, impaired lymphatic drainage, direct invasion of pleural space by tumor & malnourishment (hypoalbuminemia)
Etio: Primary sites of MPE tumors - lung, lymphoma, breasts, ovary
Tx: Thoracentesis & tx of malignancy (radiation, chemo)