Pulmonary 3 Flashcards
What is hypersensitivity pneumonitis?
“extrinsic allergic alveolitis”
allergic response after inhalation of organic dusts, or simple chemicals in sensitized patient, leading to granulomatous inflammation of the alveolar epithelium
Delayed reaction 4-6 hrs after exposure
What are some clues that strongly suggest a dx of hypersensitivity pneumonitis?
recurrent pneumonia, particularly with regularity or a pattern
respiratory symptoms after move to a new place
contact with birds - “bird fancier’s lung”
water damage home or school facility (mold)
use of a hot tub, sauna, or swimming pool
exposure to other people with similar symptoms
improvement of symptoms when the pt is away extended period, eg vacation
What is the etiology of hypersensitivity pneumonitis?
inhaled organic dusts—fibers (cotton, flax) bagasse (sugar cane), hemp, coffee, bean dust, animal dander, mold, cheese, hay, maple bark, cedar oil, birds, moldy saw dust, wheat flour, brewer’s yeast, mites, compost, detergent, paints/resins
What are the SSxs of hypersensitivity pneumonitis?
often nonspecific
chronic or recurrent cough and SOB or a history of recurrent episodes/exacerbations of acute respiratory symptoms without definite infectious triggers
What are the 3 types of hypersensitivity pneumonitis?
i. Acute hypersensitivity pneumonitis: acute onset, usually within 4-6 hrs after exposure.
fever, chills, dry cough, chest tightness, malaise, headache, ill appearance, tachypnea, crackles (often heard at the lung base), dyspnea, often NO wheezing
resolves within 12 hrs to days after the antigenic exposure is eliminated
ii. Subacute hypersensitivity pneumonitis: gradual onset (less severe, lasts longer)
cough (which may be productive), dyspnea, fatigue, anorexia, weight loss, ill appearance, tachypnea, crackles
iii Chronic hypersensitivity pneumonitis: insidious onset
cough, progressive dyspnea, fatigue, weight loss, and exercise intolerance; crackles, possible digital clubbing, and an inspiratory squawk in some patients
What are lab/imaging results associated with hypersensitivity pneumonitis?
CBC, allergy testing, PFT (restrictive changes), BAL (shows lymphocytosis)
Radiographic studies may show irreversible pulmonary fibrosis.
Acute: diffuse interstitial micronodular “ground-glass” opacities
Subacute: micronodular or reticular opacities
Chronic: loss of lung volume, alveolar destruction (“honeycombing”)
High resolution CT scan—ground-glass opacities
Lung biopsy
What are complications of hypersensitivity pneumonitis?
permanent lung damage with pulmonary fibrosis
subpleural blebs may rupture, leading to spontaneous pneumothorax
chronic respiratory insufficiency can lead to cor pulmonale and premature death
What is acute eosiniphilic pneumonia and the SSxs involved?
unknown etiology, does not recur
rapid eosinophilic infiltration of lung interstitium
SSxs: < 7days of fever, dry cough, dyspnea, malaise, myalgia, night sweats, pleuritic chest pain. Tachypnea, crackles,. Possible pleural effusion. May progress to respiratory failure.
What are labs/imaging results associated with acute eosinophilic pneumonia?
CT, CBC (eos), pleural fluid analysis (eos, high pH), CXR (opacities, Kerley-B lines), Bronchoscopy (eos seen)
What SSxs are associated with chronic eosinophilic pneumonia?
fever, weight loss, fatigue, dyspnea, dry cough, wheezing, chest discomfort
NOTE: Clinical picture may lead to misdiagnosis of community acquired pneumonia
What drugs are associated with ILD?
over 150 drugs or categories have toxic pulmonary effects leading to respiratory symptoms, CXR changes, decreased respiratory function, histological changes
Drugs involved: Antibiotics, chemotherapy, anti-arrythmics, statins, illicit drugs (cocaine, heroin, methadone), anticoagulants
Diagnosis based on response to withdrawl of the suspected drug
Asbestosis - SSxs/PE?
inhalation of asbestos fibers. Source: mining, milling, manufacture
leads to pulmonary fibrosis - dose dependent, pleural thickening
Also can lead to bronchogenic carcinoma (10x > risk in non-smokers; 60-90x in smokers) or malignant pleural mesothelioma (seen on CXR and staged with chest CT)
SSxs: insidious onset of dyspnea, exercise limitation, dry cough (unless 2° infection)
PE: mid to late inspiratory crackles, tachypnea
late findings: cyanosis, pulmonary hypertension leading to cor pulmonale
Silicosis - SSxs/PE?
inhalation of very fine silica particles– Source: mining, pottery, sand-blasting, brick-making, foundries (cast metals), glassmakers etc.
occurs 5-20 yr. after 1st exposure, ≥1 cm nodules in upper lobes seen on CXR, eggshell calcification of hilar nodes
smoking or mycobacterium infection increase effect
SSxs: insidious onset of dyspnea, exercise limitation, dry cough (unless 2° infection)
later weight loss, hemoptysis
PE: mid to late inspiratory crackles, tachypnea
late findings: cyanosis, pulmonary hypertension leading to cor pulmonale
Anthracosis - SSxs/PE?
“black lung” >15 yr. exposure, worse in smokers
SSxs: may be no respiratory symptoms or insidious onset of dyspnea, exercise limitation, dry cough (unless 2° infection)
PE: mid to late inspiratory crackles, tachypnea
late findings: cyanosis, pulmonary hypertension leading to cor pulmonale
Berylliosis - SSxs/PE?
mineral beryllium dust from older fluorescent light bulbs, ceramics, chemical plants, electronics, aerospace industry
SSxs: insidious onset of dyspnea, exercise limitation, dry cough (unless 2° infection), weight loss
PE: mid to late inspiratory crackles, tachypnea
late findings: cyanosis, pulmonary hypertension leading to cor pulmonale
What are other environmental causes of pneumoconiosis/ILD?
talc, Fe oxides, tin oxide, titanium, Cd, aluminum, iron, cotton
What is occupational asthma? SSxs?
Asthma caused by workplace materials. Type 1 hypersensitivity affecting the bronchi
Numerous compounds may cause reversible airway obstruction: castor bean, grain, detergent, red cedar wood, formaldehyde, antibiotics, epoxy resin etc.
SSxs: SOB, chest tightness, wheezing, cough and perhaps sneezing, rhinorrhea, tearing—which may not occur until several hours after exposure - temporal association with work
Can be detected by using Peak Flow Meter at work
What is irritant gas inhalation injury? Some gases involved?
Inhaled gases dissolve in respiratory tract fluids, release acidic or alkaline radicals which cause inflammation in trachea, bronchi, bronchioles, alveoli (into interstitium)
May be from industrial accidents, mixing household ammonia with bleach (chloramine)
Directly toxic agents: cyanide, carbon monoxide
Displace O2 leading to asphyxia: methane, carbon dioxide
Others: chlorine, sulfur dioxide, hydrogen sulfide, nitrogen dioxide, ammonia
What are SSxs and potential complications of irritant gas inhalation?
depends on extent and duration of exposure
severe burning of eyes, nose, trachea, bronchi with cough, hemoptysis, wheezing, retching, dyspnea
May leads to ARDS or Bronchiolitis obliterans (granulation tissue accumulates in bronchioles and alveolar ducts)
What are characteristics of air pollution related illness?
Airway hypersensitivity to Agents: oxides of nitrogen and sulfur, ozone (irritant and oxidant), carbon monoxide, lead, volatile organic compounds (eg methane), chlorofluoro carbons, particulates
Triggers exacerbations in asthmatics, COPD
Most vulnerable: elderly, kids, those with underlying lung disease
Airway inflammation, bronchoconstriction, may be permanent decrease in lung function
What are the 2 pulmonary vasculitides disorders?
Wegener’s granulomatosis
autoimmune condition that affects lung, nose, kidneys
Pulmonary infiltrates, rhinosinusitis, alveolar hemorrhage, glomerulonephritis
SSxs: Cough, dyspnea, hemoptysis, pleuritic pain, hematuria, proteinuria
Churg-Strauss syndrome
“Allergic granulomatosis and angiitis”
allergic rhinitis, asthma, alveolar hemorrhage
Also can affect GI, liver, and heart
What connective tissue disorders are associated with pulmonary manifestations?
Goodpasture’s syndrome
RA - Rheumatoid Lung disease
Lupus (SLE)
What are the characteristics of goodpasture’s syndrome?
pulmonary hemorrhage with severe and progressive glomerulonephritis
often in young men, present with severe hemoptysis with secondary Fe deficiency, dyspnea and rapidly progressive renal failure
What are the characteristics of rheumatoid lung disease?
Autoimmune disease of joints (pain, stiffness, deformity), skin (nodules), lungs, kidney
usually in a pt. with sero-positive rheumatoid factor
Pulmonary SSxs: pleuritic chest pain, pleural effusion
CXR shows nodules in lungs, interstitial fibrosis, vasculitis