Pulmonary Flashcards
what is the primary function of the respiratory system?
gas exchange
what to the lungs enable the body to do?
obtain adequate oxygen to meet cellular metabolic demands
and
remove carbon dioxide produced
healthy _ _ & _ are necessary to supply oxygen and nutrients to all tissues
nerves, blood and lymph
what do the lungs do to already inspired air?
warm, filter and humidify
what is the respiratory centre?
what it involves, where its located & what it does
involves: structures that generate rhythmic respiratory movements and reflexes
Located: medulla and pons
Does: electrical impulses are generated here and are carried by phrenic nerves to the diaphragm and other respiratory muscles
airways have 12 types of _
epithelial cells
most epithelial cells that line the trachea, bronchi and bronchioles have _
cilia
the epithelial surface of alveoli contain _
macrophages
what do macrophages do?
through phagocytosis, the macrophages engluf inert materials and microorganisms and digest them
what is surfactant?
- secreted from alveolar cells
it maintains the stability of pulmonary tissue by decreasing surface tension of fluids that coat the lung
what are the metabolic functions of the lungs?
1. help regulate acid base balance
- body pH is partially maintained by proper balance of CO2 and O2
2. synthesize arachidonic acid (AA)
- that may be converted to prostaglandins or leukotrienes
- these play a role in bronchoconstriction seen in asthma
3. converts angtiotensin 1 to angiotensin 2
- done by angiotensin-converting enzyme (ACE), found mainly in the capillary beds of the lungs
4. can function as a chemical filter
5. protect systemic circulation
- from exposure to high levels of circulating vasoactive substances
malnutrition and the pulmonary system
malnutrition adversely affects
- lung structure, elasticity and function
- respiratory muscle mass, strength and endurance
- the lungs immune defense mechanisms
- control of breathing
what is the effects of a pulmonary diagnosis on nutrition status?
- substantially increase energy requirements
- malnutrition-related impaired immunity increases risk for developing respiratory infections
- hospitalized pts
- lengthy stays
- susceptible to increased morbidity and mortality
Complications of pulmonary dx and their tx can negatively impact:
_
_
- Food intake
- digestion
Absorption & metabolism of most nutrients are affected
what symptoms are often present in pts with pulmonary diagnosis?
- Abnormal production of mucus
- Vomiting
- Tachypnea (rapid and shallow breathing)
- Hemoptysis (spitting up blood)
- Thoracic pain
- Nasal polyps
- Anemia
- Depression
- Altered taste (medication-related)
pulmonary diagnosis often persists in increased energy expenditure related to:
- increased work of breating
- chronic infection
- medical treatments
pulmonary diagnosis often causes reduced intake related to:
- fluid restriction
- shortness of breath
- decreased oxygen saturation while eatings
- anorexia of chronic disease
- GI distress and vomiting
in regard to pulmonary diagnosis there can also be additional limitations related to:
- fatigue-related difficulty with meal prep
- lack of financial resources
- impaired feeding skills (for infants and kids)
- altered metabolism
- food drug interaction
Primary vs secondary pulmonary disorders
primary:
- TB, asthma, lung cancer
Secondary
- associated with CVD, obesity, HIV, sickle cell or scoliosis
acute vs chronic pulmonary disorder
acute:
- airway obstruction, anaphylactic allergy, aspiration pneumonia
chronic:
- CF, COPD
describe how you would assess a pt for pulmonary dx
- obtain history with a focus on:
- smoking, inhalation of toxins, and any other relevant exposure - percussion and auscultation
- imaging procedures, arterial blood gases, sputum cultures and biopsies
- signs and symptoms to look for:
- cough
- dyspnea
- fatigue
- early satiety
- sputum production
- chest discomfort
- weight loss
what are pulmonary function tests and what different types are there?
PFTs are used to diagnose or monitor the status of lung dx
- Designed to measure the respiratory system’s ability to exchange O2 and CO2
Pulse oximetry
- uses light waves to measure O2 saturation of arterial blood
Spirometry
- breathing into a spirometer that gives information on:
- - Lung volume & rate at which air can be inhaled & exhaled
what is CF?
Life-threatening autosomal recessive inherited disorder
what is CF caused by?
mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) protein
CFTR PROTEIN MUTATIONS
the CFRT defect causes impaired transport of _, _, and _.
this results in the production of thick, viscous secretions in:
this leads to increased salt content in _
Cl, Na, and HCO3
- lungs
- pancreas
- liver
- intestines
- reproductive tract
sweat
what are the 2 predominant burdens of CF?
lung disease and malnutrition
“classical” presentation of the CF diagnosis is when an individual has an elevated _ _
sweat chloride (greater than 60 mmol/L)
CF pts present with persistent _, _ and _
chronic cough, dyspnea ( SOB) and wheezing
as CF diagnosis progresses, pts develop _
bronchiectasis
what might you see on physical exam during the diagnosis of CF?
clubbing
in a pt with CF what does lung auscultation reveal?
crackles in lungs and decreased breath sounds
what does the pulmonary function test show in CF pts?
airway obstruction
the spirogram shows decreased expiratory volume and decreased ratio
what is pancreatic insufficiency?
- pancreas fails to make adequate enzymes to digest food in the small intestine
- most common GI complication of CF
- 90% or less pts have fat malabsorption by 1 yeat of age
- steatorrhea: failure to thrive, poor weight gain
- some present with deficiency in fat soluble vitamins
— frequentyl present with suboptimal vit D status
— also suffer from vit K deficiencies
what is pancreatitis?
Abnormal pancreatic secretions cause progressive damage to the pancreas, resulting in acute or recurrent pancreatitis
what is CF-related diabetes (CFRD)?
what is it associated with and when should screening begin?
Associated with poor growth, clinical & nutritional deterioration & early death
Annual CFRD screenings are recommended beginning at age 10 yrs
Bone disease in CF
what is it characterized by and what are the risk factors?
Characterized by ↑ fracture rates, low bone density & kyphosis (increased curvature of the upper back)
Risk factors include:
1. Chronic corticosteroid use
2. Multiple courses of antibiotics
3. Failure to thrive
4. Malabsorption of calcium, Vit. D, Vit. K, Mg
5. Inadequate overall intake
6. Reduced weight-bearing activities
what drug is used to treat CF?
ivacaftor
restores functioning of a mutant CF protein
medical management of Cf consists of:
- chest PT
- Nebulizer therapy
- anti-inflammatory agents
- pulmonary hygiene
- pneumococcal and influenze vaccines
- chronic prophylactic antibiotic use
pancreatic enzyme replacement therapy (PERT) helps…..
helps inhance CHO, protein and fat absorption among CF patients
- it is the first step taken to correct maldigestion and malabsorption
why would we prescribe PPI’s to CF patients?
to ensure duodenal pH is high enough for the PERT capsule to degrade
the amount of PERT a CF patient recieves depends on….
- the degree of pancreatic insufficiency
- quantity of food eaten (&portion of macronutrients)
- type of enzyme used
The dosage of PERT per meal or snack is adjusted based on…
the pts GI symptoms and growth (in kids)
- if GI symptoms cannot be controlled, enzyme dose, pt adherence and enzyme type should be reevaluated
why is growth failure a common problem in CF pts?
Malabsorption
↑ energy needs
↓ appetite
women with a BMI less than _ and men with a BMI less than _ should be referred for a full nutrition assessment for CF
women: less than 22
men: less than 23
in children with CF what should you monitor yearly for?
PTH levels
25 hydroxy-vitamin D levels
Serum calcium
Serum phosphate
Bone Density (DXA) (for older children)
What are the 4 goals of MNT for CF pts?
Increasing muscle strength
Promoting optimal growth
Weight maintenance
Enhancing quality of life
what are the energy recommendations in newborns-2 , ages 2-20 and adult male/female
percentiles and BMI
Newborn-24 months: weight/length greater than or equal to 50th percentile (CDC charts)
Maintaining BMI 50th– 85th percentile for age between 2-20 years
Maintain BMI of 22-27 for adult females and BMI 23-27 for adult males
all CF pts should take 1500 - 2000 IU _ per day and up to 10000 IU/day for CF pts 18 or older
Vitamin D
how much vitamin K should be taken?
1000 mcg or more/day
what is asthma and what are the symptoms?
Chronic disorder that affects airways
- Characterized by bronchial hyper-reactivity, reversible airflow obstruction, airway remodling
Symptoms include:
- Periodic episodes of chest tightness
- Breathlessness
- Wheezing
* symptoms usually worsen at night
what is Extrinsic asthma?
chronic allergic inflammation of airways
what is intrinsic asthma?
triggered by nonallergic factors such as exercise, certain chemicals and extreme emotions
why might we not provide pts with chronic corticosteroid therapy?
can ↑ risk of osteopenia, bone fracture or steroid-induced hyperglycemia
what are the essential compoents of medical management for asthma?
- routine monitoring of symptoms and lung function
- Patient education
- Control of environmental triggers
- Pharmacotherapy
- —Tailored to the individual
- —Step-wise – dependent on attack classification
what is the RD’s purpose in treating asthma?
Addresses dietary triggers
Corrects energy & nutrient deficiencies/excess in the diet
Educates the pt on personalized diet
Monitors growth (in children)
Watches for food-drug interactions
_ and food allergies are 2 common dietary triggers of asthma
GERD
What should you be aware of if the pt is on maintenance oral steroids?
potential drug-nutrient interactions
what are the risk factors for COPD?
Smoking
Biomass fuel used for cooking and heating
occupational smoke or dust
Air pollution
Genetic factors