PULMO-SLEEP APNEA Flashcards
Why do we sleep?
Brain wake and evolved Restoration Conservation of energy Protein Impacts immune system Allow processing of input Memory consolidation depends on sleep
What are the Socioeconomic Consequences?
40 mill Americans suffer from chronic disorders of sleep and wakefulness.
ES ,OSA-93%- W, 82% -M not clinically dx
Excessive daytime sleepiness (EDS) impairs:
Human performance that can lead to accidents home, road, career
31% drivers fall asleep-
Academic performance, learning, and judgment
Increased weight, mood disorders, stress, cardiovascular complications
Inc. infections
Definitions of Sleep
reversible behavioral state of perceptual disengagement from, and unresponsiveness to, the environment.- not aware
very complex amalgam of physiologic and behavior processes.
A process, unlike coma, that is physiologic, recurrent, and reversible.
Where is the body’s master “clock”
suprachiasmatic nucleus (SCN) of the hypothalamus. Behind eyes Crossing some optic chiasm
Light-dark signals reach the SCN via a retinohypothalamic track fibers.
Circardian- about a day
SCN cells are circadian oscillators, exhibiting a stable, biphasic firing cycle. synchronized by exposure of light.
Sleep hygiene
How to keep circadian clock on time?
Regular wake up time-more important than sleep time
Bright light sun exposure helps more
Keep Circadian Clock on Time:
Awaken at approximately the same time each day.
Obtain bright light (e.g. sun) during desired daytime hours.
Maximize Homeostatic Sleep Drive:
Limit napping when insomnia is a problem
“siesta” or afternoon nap is fine if no trouble sleeping at night.
Go to bed only when sleepy.
Reduce Physiological and Psychological Arousal:
Limit or eliminate caffeine, chocolate, nicotine, alcohol.
Exercise long before bedtime (morning exercise works well).
Shut your day down at least 1 hour before bedtime.
Sleep in a comfortable bedroom, especially not too hot.
Agent blocks adenosine
Caffeine
Improve Sleep Hygiene tips
Take hot showers or baths at least 2 hours before bedtime.
Place the alarm clock where it cannot be seen.
Keep the bedroom dark, quiet, and cool, with no pets.
Avoid stressful activities in the evening.
Use the bed only for sleep and intimacy.
Sleep ROS
Do you wake up feeling rested and refreshed?
How long does it take you to fall asleep?
Do you snore, or has your bed partner complained about you snoring?
Do you have any leg discomfort at night?
The alerting effects of the biologic clock:
Oppose the Homeostatic Sleep Drive with its alerting effect.
Allow for a consolidated WAKE during the subjective day.
Initiate a mid-day dip in biologic clock alerting activities.
Homeostatic Sleep Drive:
It is proportional to the amount of previous WAKE and Sleep Debt.
Sleep Debt builds throughout the day.
What’s normal: Adults need 7-8 hours of sleep, Children need 9 or more hours of sleep
DM and HTN
affect sleep
When Patients Say They Are Tired EDS vs. fatigue Sleepiness: able to sleep if given a chance Fatigue: tired but does not fall asleep Body is tired but mind is very active
Ask the patient: If given a chance to stretch out and sleep right now, what would happen?
There is a pos-test question on this. This is a simple but very important concept for primary care providers. The questions from the Epworth should guide them
Epidemiology of Insomnia
Overall prevalence of an insomnia symptom within the last year: ~30%
Risk factors:
Female gender
meta-analysis of 31 studies: relative risk (RR) = 1.41
Medical, psychiatric, and substance abuse issues
Social factors (many co-vary)
Possible genetic factors
Age
You can quickly review some specifics social factors should include: Lower socioeconomic status Unemployment Marital status (divorced or widowed) Lack of education Race, ethnicity, country of origin Shift work Poor sleep hygiene Adverse sleeping environment Far-northern latitudes
Sleep-Related Arousal As a Trait
Primary insomnia
Markers of hyperarousal:
Reduced parasympathetic tone
Increased basal metabolism
Elevated circulating catecholamines
Increased electroencephalogram (EEG) ß activity (cortical activation)
Elevated body temperature
High activity of hypothalamo-pituitary-adrenal axis
Psychophysiologic: Characteristics
Contributed to and reinforced by poor sleep hygiene
Tension, anxiety, arousal in association with efforts to sleep, or in the usual sleeping environment
Negative expectations regarding ability to sleep
Clockwatching
Ability to fall asleep when not trying to
Better sleep away from home
Cognitive-Behavioral Treatment of Insomnia
Counseling in sleep hygiene
Cognitive therapy and stimulus control therapy
Sleep restriction therapy
Improve patient’s understanding of his/her sleep
Establish realistic expectations regarding sleep
Review simple relaxation techniques
Dissuade patient from believing lack of sleep will be harmful
Most Insurance will reimburse PCPs’ for patient education not cognitive therapy
Relaxation techniques could include deep breathing, reduce stimulation, etc
