Pulm: Mechanism of Action Flashcards
Decreases smooth muscle irritability
Anti-inflammatory immunosuppresive and anti-proliferative activity
Fluticasone (Flovent)
Decreases smooth muscle irritability
Anti-inflammatory early after administration by decreasing migration of WBCs, reversal capillary permeability, immunosuppressant
Later onset of inhibition of protein synthesis in nucleus of cell
Prednisone
Decrease smooth muscle irritability
Stabilizes mast cell membrane to prevent degranulation and release of histamine, leukotrienes, slow-reacting substance of anaphylaxis
Cromolyn MDI
Decreases smooth muscle irritability, selective and competitive antagonist of leukotriene receptors D4 and E3, slow-reacting substance of anaphylaxis (SRSA)
Zafirlukast (Accolate)
Selective, long-acting beta 2 agonist (LABA)
Salmeterol
LABA Long acting beta 2 agonist
Formoterol
Bronchial smooth muscle beta 2 sympathetic receptor stimulation
Racemic mixture with R Isomer ACTIVE and S Isomer INACTIVE
Albuterol (Ventolin)
PDE blockade causes increased levels cAMP which produces bronchodilation, diuresis, DNA and cardiac stimulation, release of epinephrine
Theophyline
Rapid acting selective beta 2 receptor agonist
Counteracts bronchospasm
Pure R-isomer form of drug
Levalbuterol (Xopenex)
Blocks acetylcholine cholinergic receptors in bronchial smooth musle to reduce bronchospasm (short term)
Ipratorprium (Atroven)
Blocks acetylchoine at parasympathetic receptors in bronchial smooth muscle producing bronchodilation
Tiotropium (spiriva)
Combination of two agents with different bronchodilating action
Anti-muscarinic and Beta 2 agonism
Umeclidinium and vilanterol
Anoro Ellipta
Umeclidinum and vilanterol
Anti inflammatory action of steroid and bronchodilaton activity of beta 2 agonist
Advair HFA/Diskus
Fluticasone/Salmeterol
Anticholinergic and beta 2 agonist bronchodilating mechanisms
Combivent
Ipratropium/Albuterol
Anti-inflammatory action of a steroid and bronchodilation activity of beta 2 agonist
Budesonide/Formoterol
Symbicort MDI
Durg and active metabolite inhibit BDE4 increasing cAMP ininflammatory and structural cells
Suppresses cytokine release
Inhibit drug infiltration by WBCs
Decrease pulmonary remodeling in COPD
Roflumilast
(Daliresp)
Binds to IgE antibody receptors on mast cells, blocking attachment of IgE antibody and preventing degranuatlion release of histamines, leukotrienes
Omalizumab (Xolair)
Biphasic CNS and ANS nicoteine recpetor stimulant
Low dose = stimulation ANS ganglia
High dose = stimulation followed by blockade of transmission
Nicoderm patch
Nicorette Gum
Nicotrol Inhaler
Nictorol nasal spray
2nd line after nicoteine supplement
Unknown MOA
Bupropion
Wellbutrin
Zyban
3rd line
Prevents nicotine stimulation of the mesolimbic dopamine system
