Pulm Flashcards
What is increased in patients with emphysema-dominant chronic obstructive pulmonary disease?
Residual volume
Which tuberculosis drug is associated with hepatitis and peripheral neuropathy? This drug may also interact with tyramine-containing foods
Isoniazid
A 44 year old male is involved in a motor vehicle accident. On physical exam, he has distended jugular veins with decreased pulses only on inspiration. There are decreased breath sounds on the entire right side. The heart sounds are not muffled. What do you do?
Insert a large bore needle into the second intercostal pleural space followed by chest tube thoracostomy
Distended juglar veins and decreased breath sounds indicate a….
Tension pneumothorax
Which type of pneumothorax is defined as a pneumothorax in which the increasingly positive pressure displaces or kinks the great vessels, leading to a marked decrease in cardiac output and forward flow. The blood that can’t go forward backs up into the jugular veins and causes JVD
Tension pneumothorax
Emergent management is needle decompression to restore cardiac output followed by chest tube placement
Tension pneumothorax
What is typical for a physical exam finding consistent with a right middle lobe pneumonia?
Dullness to percussion, Bronchial breath sounds, Egophony on the R side
Bronchial breath sounds and ego phony are associated with..
Lobar pneumonia
Hyperresonance to percussion with trachea deviation to opposite side
Tension pneumothorax
Resonance to percussion, vesicular breath sounds, normal fremitus
Normal exam!
Dullness to percussion, decreased breath sounds, decreased fremitus
Pleural effusions
Hyperresonance on percussion, decreased breath sounds, decreased fremitus
Pneumothorax or hyperinflation (i.e. severe emphysema)
Any disease that decreases the alveolar total surface area will decrease..
diffusing lung capacity for carbon monoxide (DLCO)
Protein in the lungs that prevents macrophage enzymes (such as elastase) from destroying the elastic tissue of the lung
Alpha-1 antitrypsin
Smoking can cause a relative ______ deficiency?
Alpha-1 antitrypsin
leading to decreased elasticity
55 year old male presents with a persistent cough. A CT scan of the chest shows lack of tapering of the bronchi and bronchial wall thickening. Pulmonary function tests show a decreased FEV1 and a decreased FEV1/FVC ratio of 65%. What is the dx?
Bronchiectasis
Hallmark=lack of tapering of bronchi and bronchial wall thickening**
Enlargement of the larger airways
Hallmark is lack of tapering of the enlarged bronchi and bronchial wall thickening*
Bronchiectasis
What kind of general disorder is associated with a FEV1/FVC ratio of
Obstructive disorder
Which of the following is considered a positive PPD test?
A. HIV pos female with a PPD of 4 mm induration and 8 mm erythema
B. A Physician Assistant with a PPD of 11mm induration and 5mm erythema
C. 40 yo male w no risk factors with PPD of 11mm induration and 5 mm erythema
D. 45 yo male w history of a granuloma on chest radiograph w a PPD of 4 mm induration and 10mm erythema
E. 32 yo prison inmate w PPD of 8mm induration and 10mm erythema
B, a Physician Assistant w a PPD of 11 mm induration and 5 mm erythema.
In evaluation of a PPD, the erythema is NOT part of the measurement, only the transverse induration. Because the pt is a health care worker and is at risk of occupational TB exposure, >10mm induration is considered a positive finding
An HIV pos pt needs what measurement to be considered pos for a PPD test
> or equal to 5mm
A pt with hx of granuloma on chest X ray needs ____ mm on PPD test for it to be positive
5mm or greater
A pt with no risk factors needs what size PPD to be positive?
15 mm or higher
A prison inmate needs what size PPD to be positive?
10 mm or higher
A 40 yo female presents w bilateral anterior shin redness that is tender to palpation. She is also complaining of eye pain and redness as well as the insidious onset of a nonproductive cough. A chest radiograph is performed, showing bilateral hilar lymphadenopathy. You notice a rash on her face consistent with lupus perinea. What is her dx and what is the pathophysiology going on?
Dx= Sarcoidosis
Pathophysiology= idiopathic, exaggerated T cell response with the formation of noncaseating granulomas
Why are corticosteroids used in the tx of Sarcoidosis
They blunt the immune response and decrease the granuloma formation
If a pt has erythema nodosum (bilateral anterior shin redness that is tender to palpation), ALWAYS consider…
Sarcoidosis
Uveitis (eye pain and redness) and pulmonary involvement (non productive cough w a chest radiograph showing BILATERAL HILAR LYMPHADENOPATHY), think….
Sarcoidosis
The production of caseating granulomas w central caseous necrosis in tissues is seen in..
TB
Inflammation reaction to an organic antigen describes the pathophysiology of
Hypersensitivity pneumonitis
What is the most common cause of a transudative pleural effusion?
Congestive Heart Failure (CHF)
accounts for 90%
A _______ effusion is caused by fluid shift out of capillaries either due to 1) increased hydrostatic pressure or 2)decreased oncotic pressure (albumin makes up the majority of oncotic pressure)
Transudative
If you don’t make any albumin in cirrhosis or you lose albumin in the urine in nephrotic syndrome, what can happen?
Transudative effusion
bc Albumin needed for oncotic pressure
A 36 yo woman w no past medical hx presents to the ER with sudden onset of L sided chest pain and SOB. She denies any trauma but states that she recently drove 24 hours from Florida to NY in her car. She is on an oral contraceptive pill and she smokes half a pack of cigarettes a day. Her vitals: Temp 98.6, HR:128 and regular, BP 130/88, RR:26, O2 sat 92% on room air. Physical exam is unremarkable. What is the next step?
A. Pulmonary angiography B. Venous doppler of the lower extremities C. VQ scan D. Spiral CT scan of chest w contrast E. D-Dimer
D, Spiral CT scan of chest w contrast
Classic PE presentation.
A Spiral CT scan of the chest w IV contrast is considered the BEST initial screening test for a PE in a pt w moderate to high clinical suspicion
(if this Q asked for the Gold Standard, it would be Pulmonary Angiography, bc it is noninvasive!
What is the best initial test for PE in a patient with moderate to high clinical suspicion? (i.e. young female smoker on OCP and recent hx of long travel)
Spiral CT scan of chest w contrast
What is the GOLD STANDARD for diagnosing a PE? (due to its lack of invasiveness)
Pulmonary Angiography
What diagnostic to use if suspecting a DVT?
Venous doppler
A D-Dimer should only be used for possible PE in..
low risk patients
Can you do a VQ scan to look for a PE if the pt has an allergy or contraindication to dye?
YES!
cannot use spiral CT scan w contrast tho!
A 33 yo male has been complaining of progressive SOB w exertion. Physical exam reveals pursed lip breathing, increased AP diameter, decreased remits, hyper resonance to percussion and decreased breath sounds. Chest radiographs show darkened lung fields with flattened diaphragms. Upon questioning the pt, he says he has never smoked nor lived w smokers. Which test would likely show the etiology of his symptoms?
Alpha-1 antrypsin levels
always suspect AAT deficiency in a young pt w emphysema who is not a smoker
Angiotensin converting enzyme (ACE) is elevated in..
Sarcoidosis
Sweat chloride test is seen with..
Cystic Fibrosis
A 32 yo physician who recently moved to the US from China presents t clinic for yearly TB screening. A PPD reveals 10 mm induration and 5mm erythema. Nothing abnormal seen on CXR. What is the treatment of choice?
isoniazid + pyridozine (B6) total duration of tx for 9 months
*must first realize his PPD test was pos, but the lack of results on CXR means he has LTBI (not active)
DOC for latent TB infection
Isoniazid (INH) + B6 (to prevent peripheral neuropathy from INH)
Isonizaid + rifampin + ethambutol + pyrazinamide
Tx for ACTIVE TB if treating for 9 month duration
Isoniazid + rifampin+ ethambutol+ streptomycin
Tx for ACTIVE TB if treating for 6 month duration
Ceftriaxone + azithromycin is DOC for..
Inpatient Community Acquired Pneumonia
A 66 yo old male w chronic bronchitis has symptoms consistent w cor pulmonale. Which medication has been shown to reduce overall mortality?
OXYGEN!
Oxygen has been shown to decrease mortality by reducing the hypoxemia-mediated vasoconstriction, decreasing the workload of the right side of the heart