PUD Meds Flashcards
1
Q
Sucralfate/carfate
A
Nonabsorbable aluminum salt -coats irritated areas, NOT absorbed Mucosal protective agent antipepsin --adhere to ulcer as effective as antacid and H2 ADVANTAGE: non systemic Side effects: mild constipation
2
Q
Misoprostol/cytotec
A
Prostaglandin
Indicated for prevention of ulcer assoc. w/ NSAID use, incl ASA
–Prob: Dosed 4x/d, causes diarrhea
–not used as much – PPI used for prophylaxis
MC use: abortion (prostaglandin –> uterus to contract)
CYTOPROTECTIVE – enhances natural gastromucosal defense mechanisms
–INC mucus secretion, bicarb secretion, blood vessel supply
ANTISECRETORY: inhibits basal/nocturnal gastric acid secretion by direct action on parietal cells
3
Q
H2 Blockers
A
DEC gastric acid secretion For ulcers for prevention or recurrence Reflux dz Blocks histamine, a stim of acid secretion, for proton pumps MOSTLY used for GERD, even chronically
4
Q
SE of H2 blockers
A
Cimetidine:
- gynecomastia (INC estrogen interaction/delivery)
- –takes HD
- galactorrhea
- impotence
- skin rashes
- leukopenia
- agranulocytosis
- hepatitis
- Cr
- Confusion in elderly
- interacts w/ p450: warfarin, theophylline, lidocaine, phenytoin
5
Q
PPI
A
Take it fasting, 1/2h before meal
Gastric acid pump inhibitor, antiulcer
Tx: active duodenal ulcer, active benign ulcer
Used w/ ABX in tx of HP infxn
6
Q
Bismuth Subsalicylate (pepto-bismol)
A
Tx ulcers d/t HP infxn Binds bac toxin and has antimicrobial effects on HP DARKENS tongue/stools --do hemoccult Dose: 2tab PO QID
7
Q
Tx HP
A
HP: g- rod Linked to: chronic gastritis, PUD, gastric CA/carcinoma/lymphoma Tx: acid reducing agent PPI, H2 blocker --makes ABX work better in stomach AMOX, CLARITHROMYCIN, AND PPI tx for 14 DAYS!
