PUD and Gastric CA Flashcards
PUD definition
defect in gastric or duodenal mucosa that extends through the muscularis mucosa into deeper layers of the wall
Layers of stomach wall
mucosa, submucosa, muscularis
Etiology of PUD
- H. pylori *
- NSAIDs *
- Other
Most common cause of PUD
H. pylori; incidence increases w/ age
may predispose to gastric CA
Inhibit gastrin release
low pH
prostaglandins
SS
Increase gastrin release
stomach distention
presence of peptides/AA
Gastrin role
increase gastric motility
stimulate parietal cells to secrete HCl and pepsinogen
Secretin role
inhibit stomach motility
decrease bile secretion
increase bicarb secretion from pancrea
1 cause of GI bleed
PUD
H. pylori description
gram (-) rod
Motile flagella (attaches to gastric mucosa)
oral-oral or fecal-oral route
disrupts protective properties by decreasing gastric mucus and mucosal bicarb secretion
raises pH
Increase risk of PUD w/ NSAIDs
- prior hx of PUD/ulcer complications
- H. pylori infection
- > 75 YO
- increased dose, time, duration of use
- concomitant use of steroid, other NSAID, anticoag, low dose ASA, SSRI, alendronate
H. pylori virulence factors
- flagella- attach, move
- urease - hydrolyze gastric urea to form ammonia, that helps neutralize gastric acid, enabling it to penetrate gastric mucosa
- Adhesins: adhere to epithelial cells
- Cause inflammation: causes G cells in antrum to secrete gastrin and therefore HCl increases
(ulcers are immediately friable)
Concomitant drugs that worsen PUD from NSAID
steroid other NSAID anticoagulants ASA SSRI alendronate
NSAIDs
ibuprofen
ASA
naproxen
toradol
MOA of PUD w/ NSAIDs
NSAIDs block COX, therefore preventing prostaglandin synthesis (PGE2) – prostaglandins inhibit gastrin secretion and increase mucous secretion, and promote epithelial cell proliferation
Prostaglandin role in stomach health
- inhibit gastrin secretion
- increase mucous secretion
- promote epithelial cell proliferation
Presentation of PUD
asymptomatic (70%)
Abdominal pain/discomfort
dyspepsia (belching, bloating, distention)
Nausea, early satiety, comiting
Complications: hematemesis, melena, fatigue, dyspnea
Gastric vs. duodenal ulcers
gastric: worse after meal (30min-1hr), vomiting, more likely to hemorrhage/hematemesis; weight loss/anorexia
duodenal: relieved by meals! (worse 2-3 hrs post meal), vomiting uncommon), less likely to hemorrhage (melena), weight gain
Melena
duodenal ulcer
hematemesis
gastric ulcer
Worse w/ meals
Gastric ulcer
vomiting uncommon
duodenal ulcer
weight gain
duodenal ulcer
PUD alarm sx
bleeding unexplained IDA early satiety unintentional weight loss progressive dysphagia/odynophagia acute onset of upper ab pain persistent vomiting family hx of UGI CA
Complications of PUD
bleeding (most common)
perforation
penetration
gastric outlet obstruction (rare)
Hemorrhage in PUD
hematemesis, melena or hematochezia
Dx/Tx of hemorrhage in PUD
stabilize with IV fluids or PRBCs
start IV PPI
perform EGD!!