PUD Flashcards
What is the mechanism of action of PPIs?
Inhibit H+K+ ATPase.
Example: Omeprazole, esomeprazole, lansoprazole
Name a common side effect of omeprazole.
Nausea.
Example: Omeprazole
What condition is esomeprazole primarily used to treat?
GERD (Gastroesophageal Reflux Disease).
Example: Esomeprazole
What is a side effect associated with long-term use of PPIs?
Vitamin B12 deficiency.
Example: PPIs
What is the primary action of H2 antagonists?
Block H2 receptors to reduce gastric acid secretion.
Example: Ranitidine, famotidine
Name an H2 antagonist that is commonly used.
Ranitidine.
Example: Ranitidine
What is a common side effect of famotidine?
Diarrhea.
Example: Famotidine
What unique side effect is associated with cimetidine?
Gynecomastia.
Example: Cimetidine
What is the primary purpose of antacids?
Neutralize gastric acid.
Example: Aluminium Hydroxide, magnesium hydroxide
Which antacid can cause constipation?
Aluminium Hydroxide.
Example: Aluminium Hydroxide
What is a potential side effect of magnesium hydroxide?
Diarrhea.
Example: Magnesium hydroxide
Name a mucosal protectant used in ulcer treatment.
Sucralfate.
Example: Sucralfate
What does bismuth subsalicylate do?
Provides mucosal protection and treats diarrhea.
Example: Bismuth subsalicylate
What is misoprostol used for?
Prevention of NSAID-induced ulcers.
Example: Misoprostol
What is a common side effect of misoprostol?
Diarrhea.
Example: Misoprostol
Which drug class is most effective for Zollinger-Ellison syndrome?
Proton Pump Inhibitors (PPIs).
Example: PPIs
Why should cimetidine be used with caution?
It has significant drug interactions due to CYP450 inhibition.
Example: Cimetidine
What is the main therapeutic use of sucralfate?
To create a protective barrier over ulcers.
Example: Sucralfate
Which drug can cause black stools?
Bismuth subsalicylate.
Example: Bismuth subsalicylate
What lifestyle modification can help manage GERD symptoms?
Avoid lying down after meals.
Example: Lifestyle modification
