Puberty disorders Flashcards
What could cause increased gonadotropin (LH, FSH), causing precocious puberty?
Most are idiopathic
CNS tumors
Gonadotropin-indendepent precocious puberty
excess estrogen and testosterone are produced without excess gonadotropin stimulation due to a tumor
Gonadotropin-dependent precocious puberty
Increased gonadotropins LH, FSH cause early puberty, gonads produce estrogen and testosterone
In whom is Gonadotropin-dependent precocious puberty more common
Girls
How do long acting GnRH agonists treat Gonadotropin-dependent precocious puberty?
- Stimulate initial release of FSH and LH
- Down regulation and desensitization of gonadotropin receptors in anterior pituitary
- Reduced FSH and LH release
- Reduced sex steroids
Hypogonadotropic hypogonadism
Gonadotropin deficiency results in low estrogen/testosterone, delayed puberty
Kallman’s syndrome is a _______
Hypogonadotropic hypogonadism
Hypergonadotropic hypogonadism aka
Primary gonadal failure
Hypergonadotropic hypogonadism
gonads do not respond to GnRH, lack of negative feedback from estrogen/testosterone causes levels to rise
Gonadal streak
Hypergonadotropic hypogonadism
Deficiency of pulsatile release of gonadotropins
Hypogonadotropic hypogonadism
Turner’s syndrome
Hypergonadotropic hypogonadism
Klinefelter’s syndrome
Hypergonadotropic hypogonadism
Kallman’s syndrome: male or female?
Either
Kallman’s syndrome is caused by
failure of fetal migration of GnRH neurons to the hypothalamus
anosmia
Kallman’s syndrome
no functional gonads
turner’s syndrome
XO
turner’s syndrome
47 XXY
Klinefelter’s syndrome
Most common form of primary testicular failure
Klinefelter’s syndrome
Feminization (due to absence of Testosterone)
Klinefelter’s syndrome
Germ cell tumors
Breast cancer
Osteoporosis
Klinefelter’s syndrome
