Puberty disorders

Question 1

What could cause increased gonadotropin (LH, FSH), causing precocious puberty?

Answer 1

Most are idiopathic

CNS tumors

Question 2

Gonadotropin-indendepent precocious puberty

Answer 2

excess estrogen and testosterone are produced without excess gonadotropin stimulation due to a tumor

Question 3

Gonadotropin-dependent precocious puberty

Answer 3

Increased gonadotropins LH, FSH cause early puberty, gonads produce estrogen and testosterone

Question 4

In whom is Gonadotropin-dependent precocious puberty more common

Answer 4

Girls

Question 5

How do long acting GnRH agonists treat Gonadotropin-dependent precocious puberty?

Answer 5

1. Stimulate initial release of FSH and LH
2. Down regulation and desensitization of gonadotropin receptors in anterior pituitary
3. Reduced FSH and LH release
4. Reduced sex steroids

Question 6

Hypogonadotropic hypogonadism

Answer 6

Gonadotropin deficiency results in low estrogen/testosterone, delayed puberty

Question 7

Kallman’s syndrome is a _______

Answer 7

Hypogonadotropic hypogonadism

Question 8

Hypergonadotropic hypogonadism aka

Answer 8

Primary gonadal failure

Question 9

Hypergonadotropic hypogonadism

Answer 9

gonads do not respond to GnRH, lack of negative feedback from estrogen/testosterone causes levels to rise

Question 10

Gonadal streak

Answer 10

Hypergonadotropic hypogonadism

Question 11

Deficiency of pulsatile release of gonadotropins

Answer 11

Hypogonadotropic hypogonadism

Question 12

Turner’s syndrome

Answer 12

Hypergonadotropic hypogonadism

Question 13

Klinefelter’s syndrome

Answer 13

Hypergonadotropic hypogonadism

Question 14

Kallman’s syndrome: male or female?

Answer 14

Either

Question 15

Kallman’s syndrome is caused by

Answer 15

failure of fetal migration of GnRH neurons to the hypothalamus

Question 16

anosmia

Answer 16

Kallman’s syndrome

Question 17

no functional gonads

Answer 17

turner’s syndrome

Question 18

XO

Answer 18

turner’s syndrome

Question 19

47 XXY

Answer 19

Klinefelter’s syndrome

Question 20

Most common form of primary testicular failure

Answer 20

Klinefelter’s syndrome

Question 21

Feminization (due to absence of Testosterone)

Answer 21

Klinefelter’s syndrome

Question 22

Germ cell tumors
Breast cancer
Osteoporosis

Answer 22

Klinefelter’s syndrome