Puberty Flashcards
Define the tanner stages (breast)
- Pre-pubertal. Elevation of papilla only
- Breast bud stage. Elevation of breast and papilla as small mound, enlargement of areola.
- Further enlargement of breast and areola
- Projection of areola and pilla to form a secondary mound above the level of the breast.
- Mature stage. Projection of papilla only
Define the tanner stages (pubic hair)
- Pre-pubertal. No pubic hair
- Sparse growth of long, slightly pigmented downy hair, straight or only slightly curled, along labia/base of penis
- Hair is darker, coarser and curlier, spreads over the superior junction of labia majora
- Adult type hair, but area covered is smaller than most adults (no spread to medial thighs)
- Adult hair quality and quantity, spread is to the medial surface of the thighs
What is the average age of menarche
12.9 years (Caucasian girls) and 12.3 years (African American girls)
_____ is the most important factor in stimulating maturation of chondrocytes and osteoblasts, ultimately leading to epiphysial fusion
Estrogen
In males, LH stimulates the ____ to produce ____ and FSH stimulates the _____ to produce _____
- LH –> Leydig cells –> testosterone
- FSH –> Sertoli cells –> inhibin
In females, LH stimulates the ____ to produce ____ and FSH stimulates the _____ to produce _____
- LH –> theca cells –> androgens (minor role until menarche)
- FSH –> granulosa cells –> estrogen and follicles –> inhibin
How long does the mini-puberty of infancy last? Why does it happen?
- Lasts a few months up to 2 years.
- Happens due to decreased circulating estrogen/testosterone causing reduction of negative inhibition of gonadotropinc
What lab values define central precocious puberty?
- Basal LH over 0.3 U/L
- Peak LH over 5.5 after Lupron
Increasing the frequency of GnRH pulses _____ the LH:FSH ratio
Increases
Define delayed puberty
Girl >13 years or boy >14 years without signs of pubertal development
List a differential diagnosis for delayed puberty
- Constitutional delay of growth and puberty
- Hypogonadotropic hypogonadism
- CNS disorders (tumors, infection, trauma, irradiation)
- Isolated hypo hypo (Kallman)
- Multiple pituitary hormone deficiencies
- Chronic disease
- Weight loss/anorexia nervosa
- Increased physical activity (female athletes)
- Hypothyroidimsm
- Prader Willi, Bardet Biefl
- Hypergonadotropic hypogonadism
- Males: Klinefelter, cryptorchidism, vanishing testes
- Females: Turner
- Primary gonadal failure (chemotherapy, radiation, surgery)
- XX and XY gonadal dysgenesis
List 3 tumors that cause delayed puberty
- Craniopharyngioma (remember: calcifications!)
- Germinoma
- Glioma
- Astrocytoma
- Hyperprolactinemia/Prolactinoma
What genes are affected in Kallman syndrome?
- X-linked Kallman syndrome: KAL1
- Kallman syndrome 2: FGFR1
- Kallman syndrome 3: PROKR2, PROK2
List 5 genes that can cause hypogonadotropic hypogonadism
- Kallman (KAL1, FGFR1, PROKR2)
- SF1
- HESX1
- LHX3
- PROP1
List 5 clinical features of Klinefelters
- Decreased upper to lower segment ratio
- Small, firm testes
- Increased incidence of developmental delay/personality disorders
- Delayed/variable puberty development
- Gynecomastia
- Tall stature