Pth Flashcards
Treat hypercalcemia associated with lymphoma
Glucocorticoids(2ry hormonal regulators of ca metabolism)
Treat hypercalcemia associated with malignancy &bone lesions assocoated with maetastasis
Bisphosphonate(alemdronate) ; non hormonal regu of ca metab
PTh drigs that cause git distress(side effect)
Bisphosphoronate(alendronate)
High doses of the drug can cause renal impairment
Alendronate(bisphosphonates)
Drug that cause osteonecrosis of jaw
Alendronate(bisphosphonate)
Drug that induce apoptosis of osteoclast
Bisphosphonate(alendronate)
The terminal half life of the drug is greater than 10!years
Bisphosphonate(alendronate)
Once absorbed about half of the drug is deposited in bone where it absorb or bind to …….. and become a permanent part of the…..
Alendronate(bisphosphonate)
Hydroxyaptite
Bone structure
Is a mixed agonist antagonist
Selective estrogen receptor modulator(raloxidfene)
Raloxifene stim estrogen recep in .. and block them in…
Bone
Breast and uterus
What are the side effects of prolonged use of estrogen?
Breast cancer and endometrial carcinoma
**2ry hormonal reg that decrease bone formation ;
**Decrease bone resorption:
**glucocorticoids
**estrogen
Estrogen is used in
Treatment of postmenopausal osteoprosis
Estrogen recep are found in
Bone
Antagonize vi d stimlated ca absorption
Glucocorticoids
**Used to treat hypercalcemia &hyperphosphatemia:
Used to treat **hypocalcemis&hypophosphatemia:
Salmon Ct
Vit-D
How is salmon Ct taken!
Parentral or intransal
Used in treatment of rickets and osteomalacia
Vit-D
What is the action of vitamin D on bone?
Increase ca depositiom
Can be synthesized in human skin by the actions of Uv rays
Vit-D3
Used in treatment of hyperthyroidism
Cinacalcet
