Psychotic Disorders Meds Flashcards
Brand name for chlorpromazine
Thorazine
CT
Is chlorpromazine high or low potency?
Low
Which med is indicated for hyperactive children who show excessive motor activity with accompanying conduct disorders?
chlorpromazine
Brand name for fluphenazine
Prolixin
fluphenazine Prolixin
FP
Is fluphenazine high or low potency?
high! more likely to cause EPS
How often would pt receive fluphenazine decanoate? (every ___ to ____ weeks)
every 2-3 weeks
to receive fluphenazine decanoate
Onset of fluphenazine decanoate is within ____ to ____ hours?
24 to 48
Brand name for haloperidol
Haldol
Is haloperidol high or low potency?
high! more likely to cause EPS
Which 1st gen antipsychotic is LOW potency?
chlorpromazine
Time for haloperidol to reach steady state?
1 week so pt may need to still take oral meds when starting the injection
Half life of haloperidol is ____ weeks?
3 weeks
What are the 2 mechanisms of action for atypical/2nd generation antipsychotics?
Mechanism of Action: D2 and 5HT (serotonin) receptor antagonism
Atypical antipsychotics have the clinical profile of equal positive symptom antipsychotic actions, but low _______ symptoms and less ________ compared to conventional antipsychotics
low extrapyramidal symptoms and less hyperprolactinemia
Atypical antipsychotics have the clinical profile of equal positive symptom antipsychotic actions, but low extrapyramidal symptoms and less hyperprolactinemia compared to conventional antipsychotics
Do atypical/2nd gen have improved efficacy over the first gens in treating the negative symptoms OR the positive symptoms of schizophrenia?
negative
improved efficacy over the FGAs in treating negative symptoms (e.g., flat affect, poverty of speech, lack of motivation and interest, poor grooming and hygiene) of schizophrenia
Brand name(s) for aripiprazole
Brand Name: Abilify, Abilify Maintena, Aristada
arip Abil
True or False: aripiprazole is not associated with any significant weight gain
True
aripiprazole is not associated with any significant weight gain
Brand name for asenapine
Saphris
Which antipsychotic is taken via sublingual tablet?
asenapine/Saphris
aSe Saph sublingual So many S’s
True or False: For asenapine, pts should NOT eat or drink 10 mins following sublingual administration so the medication does not get washed into the stomach where it will not be absorbed
True
Patients should NOT eat or drink 10 mins following sublingual administration of asenapine/Saphris, so the medication does not get washed into the stomach where it will not be absorbed
Brand names for clozapine
Clozaril, Leponex, Versacloz, Fazaclo
Agranulocytosis (low white blood cell count) is a precaution for which antipsychotic?
Clozapine
Patient’s clozapine therapy is interrupted when the ANC is less than ______ per μL?
1,000
patient’s clozapine therapy is interrupted when the ANC is less than 1,000/μL
For clozapine-
Pts are required to get weekly ANC laboratory tests from initiation to _____ months. If blood tests are normal, patients are then required to have ANC levels tested every ______ weeks for the next 6 months, and _______ after 12 months.
6 months; two weeks; monthly
patients are required to get weekly ANC laboratory tests from initiation to 6 months. If blood tests are normal, patients are then required to have ANC levels tested every 2 weeks for the next 6 months, and monthly after 12 months.
5 Signs of Neutropenia (infection)?
[from clozapine REMS slide]
Signs of Neutropenia (infection):
- Fever above 100.4 degrees
- Chills and Sweats
- Vomiting
- Diarrhea
- Shortness of Breath
clozapine should not be combined with other drugs that can suppress _______ __________?
bone marrow
Should not combine clozapine with other drugs that can suppress bone marrow
This harmful behavior can decrease clozapine levels
smoking!
Brand names for iloperidone
Fanapt
iLo Fan
I love fans in summer?!
Priapism (penis remains erect for hours w/o stimulation) is a precaution for which antipsychotic?
iloperidone/Fanapt
priapism is a precaution for iloperidone
iLo penis
Brand names for lurasidone
Latuda
Which antipsychotics should be taken with food?
lurasidone and ziprasidone
Lisa
cruZ loves food !!
Brand names for risperidone
Risperdal, Consta, Trinza
For risperidone/Consta injectable, must continue oral dosing for _____ weeks to allow injection to reach steady state
3 weeks
Must continue oral dosing for 3 weeks to allow injection to reach steady state, for risperidone/Consta
Brand names for paliperidone
Invega; Invega Sustenna, Invega Trinza
pals don’t INVade during pandemic
paliperidone Invega
What is the active metabolite of Risperdal?
paliperidone is the active metabolite of risperidone/Risperdal
Brand names for olanzapine
Zyprexa, Zyprexa Relprevv., Symbyax (Olanzapine-Fluoxetine combo)
are the brand names for olanzapine
olanZ Zyprexa
What is Symbyax made up (2)?
Symbyax = Olanzapine-Fluoxetine combo
Brand name for quetiapine
Seroquel, Seroquel XR
Que Ser?
quetiapine Seroquel
Brand name for ziprasidone
Geodon
zip to a GOOD GeOD adventure
ziprasidone Geodon
Should not combine which antipsychotic with other drugs that can suppress bone marrow?
clozapine
Which antipsychotic is known for its ability to cause akathisia (restlessness) and activation in patients?
aripiprazole/Abillify
Abilify’s thousand commercials always include being restless as a SE
Patients should not eat or drink 10 mins following sublingual administration of this antipsychotic?
asenapine/Saphris
Patients should not eat or drink 10 mins following sublingual administration of asenapine/Saphris so the medication does not get washed into the stomach where it will not be absorbed
ase don’t eat you ass
What are the 3 first gen antipsychotics?
chlorpromazine/Thorazine
fluphenazine/Prolixin
haloperidol/Haldol
4 stages of Extrapyramidal Symptoms?
1) acute dystonia
2) Parkinsonism
3) akathisia
4) tardive dyskinesia
Why do EPS occur?
bc of decrease in D2 in the nigrostrial pathway, and resulting acetylcholine imbalance
