Psychosis Tutorial Flashcards

You may prefer our related Brainscape-certified flashcards:
1
Q

What is Psychosis?

What disorders have psychosis?

A

Difficulty perceiving and interpreting reality

e.g. Bipolar disorder, schizophrenia, drug induced episode, severe depression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the 3 symptom domains in psychosis?

A

Positive
Negative
Disorganisation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the 2 main positive symptoms?

A
  1. Hallucinations - perceptions in absence of a stimulus:

2. Delusions - fixed, false beliefs, out of keeping with social/cultural background:

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the 4 main negative symptoms?

A
  1. Alogia - poverty of speech:
    Paucity of speech, little content
    Slow to respond
  2. Anhedonia - loss of enjoyment:
    Few close friends
    Few hobbies/interests
    Impaired social functioning
  3. Avolition / apathy - poor self care:
    Poor self-care
    Lack of persistence at work/education
    Lack of motivation
4. Affective flattening - unchanging facial expressions:
Unchanging facial expressions
Few expressive gestures
Poor eye contact
Lack of vocal intonations
Inappropriate affect
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are 2 main disorganisation symptoms?

A
  1. Bizarre behaviour:

Bizarre social behaviour
Bizarre clothing/appearance
Aggression/agitation
Repetitive/sterotyped behaviours

  1. Thought disorder:
Derailment
Circumstantial speech
Pressured speech
Distractibility
Incoherent/illogical speech
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the onset, course, morbidity and mortality of psychosis?

A

Onset = can occur at any age, although often during adolescence / early 20s (later peak in women)

Course = often chronic and episodic; very variable

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How do you take Psychiatric history?

A

History of presenting concern - why now? nature, severity, onset, course, worsening factors, treatment received

Past psychiatric history - any known diagnosis, treatment, known to community team, previous admissions to hospital

Background history (family, personal, social) - parents, siblings, relationships, atmosphere at home, drug abuse, suicide, mother’s pregnancy and birth, early development, education, intimate relationships, financial issues, living arrangements, alcohol / drug abuse

Past medical history and medicines - regular medications, compliance, over-the-counter medications, interactions

Corroborative history - informants, confidentiality

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the MSE?

A

Mental state examination

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What do you look at during an MSE?

A

Appearance and behaviour - general appearance, facial expression, posture, movements, social behaviour

Speech - quantity, rate, spontaneity, volume

Mood - subjective, objective, predominant mood, constancy, congruity (e.g. cheerful when describing sad experiences)

Thoughts - stream, form, content, preoccupations, morbid thoughts, suicidality, delusions, overvalued ideas, obsessional symptoms

Perceptions - illusions, hallucinations, distortions

Cognition - consciousness, orientation, attention, concentration, memory, language functioning, visuospatial functioning

Insight - awareness of oneself, recognition that they are unwell, acceptance, awareness treatment is required

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Case Study: Andy

New lecturer works for MI5, drafted in his roommates and now they’re after him
Duration - 2 months
Auditory hallucinations of his 3 housemates - they’re always talking about him, commenting on everything he is doing, but they never talk to him directly
His housemates are putting different thoughts into his brain
Convinced there is a chip put in his head, can feel it - tracking device
Physically fine

What else would you like to know about Andy?

A

What is his current mood?
Does your family have a history of similar symptoms he is experiencing?
Ask his mum about any behaviour changes?
Do he take any other medications?
Does he have any history of alcohol or drug abuse?
Has he been to the GP / hospital about these before?
Other friends he trusts?
Other social history - friends, family, siblings, support system?
Any visual hallucinations?
If he is aware these thoughts are abnormal?
How is uni going? Struggling with grades?
What do you do to keep yourself safe?
Has he tried removing the chip himself / seen other doctors etc.?

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Case Study: Andy, additional points -
6 month history of social withdrawal
8 month history of poorer functioning at uni
Problems with anxiety as a teen but no diagnosis
no previous psychotic symptoms

What are prodomal symptoms?

A

Non-specific symptoms that predate the psychosis - loss of enjoyments, anxiety, social withdrawal etc.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Case Study: Andy, more history -
Family history of SZ
Cannabis use - started 1 year ago
Early life stress - separation from dad (Estrangement), though good relationship with mum

What do we know about SZ, what are some risk factors for SZ development? (psychology)

A
Corcordance rates of 46%
Highly polygenic 
Environmental risk factors: 
drug use, esp. cannabis
Prenatal / birth complications
Socioeconomic deprivation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Perform an MSE on Andy using:

Appearance and Behaviour
Speech
Mood
Thoughts
Perceptions
Cognition
Insight
A

Appearance and Behaviour - 21 Caucasian male, average build, well kempt, appropriate clothes, little eye contact, monotone face (congruity), slouchy but sitting, looks suspicious, able to establish rapport

Speech - slightly quiet, monotone

Mood - objectively - not distressed, anxious, blunted affect, concerned about his experiences

Thoughts - paranoid and persecutory delusions; thought insertion, denies thought broadcasting and blocks

Perceptions - auditory hallucinations - 3rd person running commentary, tactile hallucinations - thinking the chip was implanted in him, denies command hallucinations

Cognition - oriented to time and place

Insight - thinks the psychiatric thinks his delusions are stupid, recognises his experiences are odd, but thinks there is nothing wrong with his delusions and does not believe he has a mental illness, minimal insight

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is derailment?

What is word salad?

A

Spontaneous speech that ends up off the track
Ideas loosely related or unrelated

Patient says string of words that make no sense

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is a pseudohallucination?

A

Experienced during personality disorders e.g. being a different character / personality

Voices in their heads, louder than their own thoughts

Not external sounds (hallucinations are perceived external sounds, not voices in the head)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are some cognitive impairments associated with SZ?

A

Working memory impairments
Lower scores on cognitive testing
Poorer educational attainment from childhood

Cognitive impairments stay stable over time and independent of psychotic symptoms

17
Q

What are some difficulties with treating someone with poor insight into their psychosis?

A

Concordance with treatments - esp. medications
Attendance to follow up sessions
Would not stay in hospital

18
Q

What would be the working diagnosis for Andy?

A

Acute psychotic episode

Not a straight away diagnosis to SZ because many people with first psychosis episode do not go on to develop more
Also many disadvantages come alongside being given a diagnosis like SZ, and have it turn out be wrong - stigma, incorrect treatment, labeling a patient, etc.

19
Q

What are all the possible differentials for a psychotic episode?

A

Drugs: Recreational e.g. cocaine, LSD, cannabis, alcohol; or medications e.g. L-dopa, steroids, anticholinergics

Metabolic: Ca2+, Mg2+, Cu2+, Vit B12

Endocrine: Thyroid, Cushing’s, Addison’s

Infections: Encephalitis, syphilis

Delirium

Head trauma, brain injury, stroke, encephalopathy

SZ, mania depression

Personality disorder

Dementia

20
Q

What would be the treatment options for Andy?

A

Pharmacological: Anti-psychotic medications

Psychological: CBT for psychosis

Social support: Supportive environments, structures and routines; housing, benefits, support with budgeting / employment

21
Q

What neurotransmitter system do most anti-psychotics target?

Do they act as agonists or antagonists? Why?

A

Dopamine, but can also act on serotonin, acetylcholine, histamine

Dopamine antagonists - increased dopamine causes psychosis
Some are partial dopamine agonists but they can cause Parkinsonian symptoms

22
Q

Case Study: Andy follow-up

Andy agrees to take an antipsychotic medication and go to psychological therapy. A few months later, Andy’s symptoms are under control but he develops some new symptoms:

Rigidity
Shuffled, slow walking / gait
Loss of arm swing in gait
‘Pill-rolling’ tremors

Why have these new symptoms arisen?

A

They are Parkinsonian symptoms
Due to extra-pyramidal side effects

Antipsychotics can cause post-synaptic dopamine blockade in the extrapyramidal system (parts of the brain that enable us to maintain posture and tone)

23
Q

What are 4 extrapyramidal side effects of antipsychotics?

A

Parkinsonianism - rigidity, shuffled walking / gait, loss of arm swing in gait, ‘pill-rolling’ tremors

Dystonia - increased motor tone = sustained abnormal posture, laryngeal dystonia = fatal, can be acute and painful

Tardive dyskinesia - usually after long term use in females, repeated oral / facial / buccal / lingual movements e.g. lip smacking, tongue movement, etc.

Akathisia - inner restlessness, feels compelled to move, relentless movement, legs commonly affected

24
Q

What are typical VS atypical antipsychotics?

A

Typical = older generation, often leads to extrapyramidal side effects

Atypical = second generation, newer psychotics, fewer if not no extrapyramidal side effects

25
Q

What are some other side effects of anti-psychotics?

A

CNS effects - extrapyramidal side effects
GI = constipation

Haematological = agranulocytosis, neutropenia

Pituitary = increased prolactin (release suppressed by dopamine)

Metabolic = increased appetite, weight gain, diabetes

Cardiac = dysrhythmia, long QTc

26
Q

What occurs to patients after psychotic episodes?

What is the long-term management plan?

A

Some people recover after psychotic episode to recover completely and remain well
Majority follow an episodic course, with periods and wellness and relapses

Long term management: community follow-up, managing anti-psychotic side effects, health promotion and reducing risk factors e.g. smoking, diet etc.