Psychosis and Schizophrenia Flashcards

1
Q

Define Psychosis

A

Mismatch between representation of reality in individual’s mind and representation supported by objective evidence

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2
Q

Classify psychosis

A

Perception and thought

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3
Q

Define Delusion

A

Unshakeable belief (fixed form belief), derived by erroneous inference, out of keeping with social or cultural beliefs

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4
Q

Themes of delusion

A

Persecution, infidelity, erotomania, grandiosity, ill-health, guilt, nihilistic, poverty

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5
Q

Symptoms of psychosis

A
  • Delusions
  • Hallucinations
  • Formal thought disorder
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6
Q

Define hallucination

A

Hallucination is a percept without object i.e. a sensory experience without an external stimulus

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7
Q

Types of hallucination

A

Any sensory modality

  • Auditory (hearing)
  • Visual (vision)]
  • Tactile (Touch)
  • Olfactory (smell)
  • Gustatory (Taste)
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8
Q

Formal Thought disorder

A

A pattern of disordered language that reflects disordered thought form

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9
Q

Examples of formal thought disorder

A
  • Loosening of association (derailment)
  • Flight of ideas
  • Circumstantial thoughts
  • Tangential thoughts
  • Thought block
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10
Q

Most common form of hallucinations within schizophrenia and psychosis

A

Auditory hallucinations

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11
Q

What % of the population are estimated to be experiencing hearing voices?

A

5-28%

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12
Q

List positive symptoms of schizophrenia

A
  • Thought disorder
  • Disorganised behaviour
  • Delusions
  • Hallucinations
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13
Q

List negative symptoms of schizophrenia

A
  • Social withdrawal
  • reduced attention
  • Blunted affect
  • Avolition
  • Poverty of speech
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14
Q

Scheider’s First Rank Symptoms

A
ABCD 
Auditory Hallucinations
Broadcasting of thought
Controlled thought (delusions of control)
Delusional Perception 

(Thought echo, third persona auditory hallucination, delusional perception, made volition, somatic passivity)

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15
Q

Clinical features of Schizophrenia

A
Reality distortion (Positive)
Disorganisation (Positive)
Psychomotor poverty (negative)
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16
Q

Characteristic reality distortions of schizophrenia

A

Third person auditory hallucinations

Alien influence over thought

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17
Q

Organic causes of psychosis

A
  • Delirium
  • medication-induced (corticosteroids, stimulants, dopamine agonists)
  • Endocrine disorders (Cushing’s, hypothyroidism, hyperthyroidism)
  • Neurological disorder (temporal lobe epilepsy, MS, movement disorders, Wilson’s disease, Huntington’s disease)
  • Systemic diseases (porphyria, SLE)
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18
Q

Schizophrenic cause of psychosis presentation

A
  • Symptoms present for longer than 28 days
  • First rank symptoms present OR persistent hallucinations and delusions
  • Negative and cognitive symptoms
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19
Q

Other psychiatric causes of psychosis

A
  • Schizoaffective disorder (mix of first rank symptoms and mood symptoms)
  • Delusional disorder (non-first rank delusional belief with minimal hallucination)
  • Schizotypal disorder
  • Acute and transient psychotic disorder (symptoms <28 days)
  • Mood disorder (Mania, severe depression)
  • Substance misuse (alcohol withdrawal, intoxication with stimulants, cannabis)
20
Q

Epidemiology of schizophrenia

A
  • 1/100 lifetime risk
  • M=F
  • Very rare <14y/o
  • Rare 14-16 y/o
  • Peak incidence = 23y/o male; 26 y/o female (second peak between 30-40)
  • Urban > rural
  • Lower social class
21
Q

Biological aetiology of schizophrenia

A
  • Genetic - family history (possible multiple genes)
  • Obstetric complication (increased risk)
  • Dopamine theory
  • Neurodevelopmental theory
22
Q

Risk of schizophrenia increases by __ if ___ has schizophrenia

A
46% - Identical twin 
40% - Both parents
15% - One sibling/fraternal twin
15% - One parent
6% - One grandparents
1% - No relatives
23
Q

Psychological aetiology of schizophrenia

A

Cognitive errors - jumping to conclusions (especially in delusions and paranoia)
Premorbid personality - schizotypal disorder

24
Q

Social aetiology of schizophrenia

A

Urban living (x2/3)
Migration (x3)
Life events (incl. physical + sexual abuse)
Ethnicity (x4 in Afro-Carribeans in UK; higher incidence in South Asians)

25
Q

Prodrome

A

The period of time where the individual is gradually developing symptoms but has not yet met the criteria for diagnosis

26
Q

Prodromal symptoms

A

Non-specific negative symptoms
Emotion distress/agitation without reason
Transient psychotic symptoms

27
Q

What is the average DUP?

A

DUP = duration of untreated psychosis

over a year

28
Q

Aims of management

A

Establish a diagnosis

Manage condition

29
Q

Management if:
Urgent/immediate concerns regarding risk s because of patient’s psychotic symptoms
BUT risks can be adequately managed in community with intensive input

A

Crisis Resolution and Home Treatment (CRHT) Team

30
Q

Management if:
Urgent/immediate concerns regarding risk s because of patient’s psychotic symptoms
BUT risks cannot be adequately managed in community with intensive input and patient is willing to come to hospital

A

Informal Admission to a psychiatric ward

31
Q

Management if:
Urgent/immediate concerns regarding risk s because of patient’s psychotic symptoms
BUT risks cannot be adequately managed in community with intensive input and patient is NOT willing to come to hospital

A

Mental Health Act (MHA) assessment to determine if patient needs detaining

32
Q

Management if:

NO urgent/immediate concerns regarding risks and patient is aged 18-35 and first episode

A

Early Intervention in Psychosis Team (EIP)

33
Q

Management if:
NO urgent/immediate concerns regarding risks and patient is NOT aged 18-35 and NOT first episode but has Established psychotic illness and needs a period of intensive psychiatric rehabilitation to improve functioning

A

Community Rehabilitation Service

34
Q

List first generation (typical) anti-psychotics

A
Chlorpromazine
Haloperidol
Zuclopenthixol
Flupentixol
Fluphenazine
35
Q

List second generation (atypicals) anti-psychotics

A
Olanzapine
Risperidone
Quetiapine
Aripiprazole
Clozapine for treatment resistant schizophrenia
36
Q

Common reasons for non-compliance in treatment of schizophrenia

A
Lack of insight
Side effects
Delusions about medication/prescriber
Patient feels better when ill
Remission from symptoms and no longer thinks medication is required
37
Q

Standardised mortality rate in schizophrenia

A

nearly 5x higher

38
Q

What physical diseases are schizophrenics at increased risk of? What are contributing factors?

A

Cardiovascular disease, diabetes, stroke

CF: poor diet, reduced physical activity, smoking, not engaging with physical health monitoring, antipsychotics increase the risk of metabolic syndrome

39
Q

Physical health monitoring in schizophrenia - Baseline measurements and every year

A

Smoking and drinking status
Personal/family history of diabetes/coronary heart disease
BP, BMI
blood for FBC, RFT, LFT, glucose and lipid
ECG

40
Q

What is TRS? How do you diagnose TRS?

A

Treatment resistant schizophrenia

TRS = lack of response to adequate doses of 2 antipsychotics. Before diagnosis, review diagnosis, rule out co-morbid substance misuse, ensure dose, duration and compliance with previous treatment

41
Q

Psychological Treatment - NICE GUidelines

A

Cognitive Behavioural Therapy - recent NICE guidelines CG178 have stated that everyone with psychosis/ schizophrenia should be offered CBTp (cognitive behavioural therapy for psychosis).

Family Intervention Therapy (FIT) - NICE CG178 also made recommendations on the provision of family intervention therapy to family members and the service user where appropriate, and offering carers education and support programmes.

42
Q

Other psychological therapies

A
PSYCHOEDUCATION
-relapse signature/early -relapse signs
-Crisis plans
-relapse prevention
-WRAP (wellness, Recovery and Action Plans)
COPING STRATEGIES
MAASTRICHT INTERVIEW (voice hearers)
CONCORDANCE THERAPY
43
Q

Social management of schizophrenia

A
  • Daytime activities/ occupation/ employment/ education/ leisure hobbies
  • Family
  • Accommodation
  • Benefits
  • Relationships
  • Cultural needs
  • Safeguarding
44
Q

Follow-up considerations for schizophrenia

A
  • Monitor mental state
  • Monitor treatment effectiveness and S/E
  • Monitor risk
  • Monitor support system
  • Further psychoeducation
45
Q

Carer’s needs (Expressed Emotion)

A

Carer’s emotional reaction to the individual with schizophrenia: 3 different domains:

  • criticism
  • hostility
  • over-involvement