Psychosis

Question 1

Answer 1

Question 2

Answer 2

Question 3

mesocortical pathway is from the the VTA to the prefrontal cortex (PFC)

Answer 3

Mesolimbic pathway is between the VTA and NAC

Question 4

In psyhcosis, there is too much dopamine release in the mesolimbic pathway from the VTA to the NAC (binds to D2 receptors) leading to positive symptoms including hallucinations

Answer 4

Question 5

In psychosis, in the mesocortical pathway there is LOW dopamine release (D1 receptors)- low dopamine binding leads to development of negative symptoms including avolition and blunting

Answer 5

Anti-psychotics will target the mesolimbic overactivation