psychoses Flashcards
Delusional Disorders
> 1 delusion, >1 month WITHOUT other psychotic sx. must be plausible but unlikely. Lanie.
> 1 psychotic sx w/ onset and remission <1month
Brief psychotic disorder
Montana w/ frostbite
meet schizophrenia definition BUT <1 month
schizoPHRENIFORM disorder
Schizophrenia + mood disturbance (mania, MDD)
ShizoEFFECTIVE disorder
Criteria for shizophrenia
> 6 months duration of illness with 1 month of acute sx almong w/ funcitional decline
> 2 positive sx and must have 1+ hallucination, delusion, or discoganized speech
(+) H sx auditory
often 3rd person, can be command
(+) H sx olfactory
stench foul smell common
(+) H sx tactile
insects on skin or being touched
(+) H sx somatic
sensation arising from within the body
(+) H sx gustatory
can be a part of persecutory delusions (tasting poison)
(+) D sx persecutory
force/person interfeing with them observing them or wishes harm to the pt
(+) D sx Refeence
ransdome events take control of patient’s thought, feelings and behaviors
(+) sx D reference
random events take on a persone sig )directed at them)
(+) sx D control
some agency takes contol o fpts thoughts eelings and behavors
(+) sx D Grandiose
Unrealistic beliefs in ones own powers
(+) sx D nihilsm
exaggered belief in the futility of evyerthing and catastrophic events
(+) sx D erotomanic
believes another person is in love with them
(+) sx D jealousy
suspects unfaithful
(+) sx D doubles
believes someone close to them has been switched by a double
(-) sx thought to be caused by dopamine dysfuntion in the mesocoritcal pathway. seritonin may play a role.
flat, social withdrawal, lack emotion, avolition (lack self motivation) lack communication, poor eye contact
RF schizophrenia
MC family hxk
MOA 2nd gen antipsycotics
dopamine and seritonin antagonists
Best for (+) sx
1st gen Haloperidol and chlorpromazine BUT cause extrapyrimidal effects
2nd gen best when develop resistance to other 2nd gen
clozapine
AE clozapine
agranuloctyosis get CBCweekly
AE olanzapine
DM
General AE 2nd gent AP
myocarditits, seizures QT porlongation, weight gain
AP 1st gen MOA
only dopamine antagonist. good for (+) sx
Extrapyramidal sx (EPS)
rididity, bradykiesia, tremor, akathisia (restlessness)
3 EPS syndromes
- Dyskinesia
- tardive dyskinesia
- parkinsominsm
Dyskinesia (dystonic reactions) - short term use
Reversible extrapyramidal sx.
happens hours after admin
decreased dop leads to increased ach
trismus, tongue protrussions, facial grimicing, torticollis, difficulty speaking
tx: diphenhydramine IV for anticholinergic properties.
or benztropine for antichokinergic agent
bezos may be used bc mediates dop/ach balance with GABA
Tardive dyskinesia (long term us)
long term use
repetative involuntary movement in extremities
lip smacking, teeth grinding, tongue rolling.
parkinsonism (low dopamine in nigrostrial)
rigidity tremor
In addition to EPS sx of 1st gen there are more SE
NMS, QT prolongation, cardiac arrythmias, sedation, ach effects, dermatitis, blood dyscrasias HIGH PROLACTIC (worse with 2nd gen). WEIGHT GAIN
NMS 1st gen
due to dopamine blockade
AMS, rigidity, tremor, autonomic instability, tachycardia, tachypnea, hyperthermia/fever
mgmt. stop agent.
tx hyperthermia w/ cookjng blaken, ice
give DOPAMINE agonists like bromocriptine, amantadine, levo/carb
Name 1st gens
haloperidol, droperidol, fluphenazine, perphernaine, chlorpromazine , thioridazine
MOA 1st and 2nd
1st = dopamine antagonist 2nd = dop and seritonin antagonist
SE of 2nd gen
EPS (less than 1st esp clozapine and quetiapine)
Increased prolactin, hyperglycemina, hyperlipidemia, weight gain, NMS
Name 2nd gen
quet, olanza, cloza, loxapine
Name benzisoxazoles
risperidone, ziprasidon
MOA benzisoxazole
Dopaminte antagonist and serotonin antagonist but at diffenet sites than second
IND for risperidone, ziprasidone
shciazoprhenia, bipolar, psychosis,
risperdal ok for tourettes
SE rispidone and ziprasidione
EPS, INCREASED prolactin, sedation , weight gain, hypotension, prolonged QT
Quinolones
aripiprazole (abilify)
MOA dopamine and serotonin antaonist, indicated for psychotic disorders. may be called 3rd gen
Lithium MOA
increases NorEP and serotonin receptor sensitivity
Lithium indications
bipolar, acute mania
Lithium SE
HYPOTHYROIDISM. ARRYTHMIAS, sodium depletion. increased urination and thirst, DI, Hyperparathyroid/hypercalcemia.
seizures , tremor, HA, weight gain, GI disturb,
Lithium pregnantcy
CI
Lithium has a narrow TI
monitor plasma levels every 4 - 8w
What behavior can carbamazepine or valproate suppress
impulse and aggressive
MDD RF
MC female, 20-40s
MDD
2weeks +, must be almost every day, >5 sx
MDD sx
andendonia, dis sleep, guilt, workthlessness, suicide, psycholoto agitation, weight change, appetite change, concentraiotn
MDD cannot be assoc
bereavment, substances, medical conditions
Somatic sx of MDD
constipation, HA, skin changes, chest or abdominal, cough, dyspnea
Subtypes “course specifiers” of MDD
- SAD
- atypical depression
- Melancholia
- Catatonic depression
MDD: SAD
same time each year
mgmt: ssri, light tx, bupropion
MDD: atypical depression
similar to MDD
BUT
experience mood reactivity (improved mood w/ (+) ecents)
sx: weight gain, appetitie, increase, hypersomina, heavy leaden felling in arms or legs, oversensitiity to interpersonal rejection
mgmt MAO inhibitors
MDD: melancholia
anhedoia, lack mood reactivity, depression, severe weight loss/ app loss, guilt, PA, or PR, sleep,
may have worse mood in the morning
MDD: catatonic depression
motor inability, stupor and extreme withdrawl
mgmt mild/ mod depression
- psychotherapy
- medications
- electroconvulsive therapy
Meds MDD
1st: SSRI
2nd snri, buproprion, mirtazapine
3rd: TCAs and MAO inhibitors
Min time to give and antiD
3-6 weeks
Name SSRIs
citalopram (celexa) escitalopram (lexapro) paroxetine (paxil) fluoxetine (prozac) sertraline (zoloft) fluvoxamine (zyvox)
MOA SSRI
inhibits CNS seritonin receptors from taking back the seritonin and hence increaseing seitonin in the cleft
Ind SSRI
1st line depression and anxiety
less SE, lower toxicity
Avoid citalopram in which patients?
long QT
SSRI - seritonin syndrome
acute AMS, seizures, coma and death, reslessess, sweating , tremor, hyperthemia, nausea, vomiting, abd pain, mydriasis, tachycardia
SNRI names
venlafaxine (effexor)
desvenlafaxine (pristiq)
duloxetine (cymbalta)
SNRI MOA
inhibits uptake of seritonin, NE, and DA
Ind SNRI
can be 1st line if have MDD with FATIGUE AND PAIN syndromes
2nd line if dont respond to SSRI
SE SNRI
same as SSRI: hyponatremia, noradrenergic sx
AND: HTN, dizziness
CI/ Cautions SNRI
renal/ hepatic ds, seizures
AVOID ABRUPT d/c
caution if have HTN
High suspicion for serotonin syndrome if using St johns wort
Name TCAs
amitriptyline (elavil) clomipramine (Anafranil) desipramine (Normpramin) doxepin (Sinequan) imipramine (Tofranil) Nortriptyline (Pamelor)
TCAs MOA
inhibits reuptake of serotonin or NE
TCAs IND
depression, INSOMINA, DM neuropathy, post herpetic neuroalgia, migraine, urge incontinence.
Nondepressed pts experience sleepiness. depressed patients feel elevated mood
TCAs why should not prescribe a truckload to MDD
easy to OD
Na channel blocker effts: sinuse or wide complex tachycardia, neurologic sx, ARDS, SIADH
SE TCAs
ANTICHOLINERGIC, PROLONGED QT (best indicator of OD)
weight gain, sedation