Psychopharmacology of Opioids

Question 1

what are the morbid factors of OUDs ?

Answer 1

respiratory depression, increased prevalence of infectious diseases (e.g., HIV/AIDS and hepatitis C)

Question 2

what are the sign and symptoms of opioids intoxication ?

Answer 2

pinpoint pupils, sedation, constipation, bradycardia, hypotension and decreased respiratory rate.

Question 3

what are the sign of opioids withdrawal ?

Answer 3

Dilated pupils lacrimation, goosebumps, diarrhea, severe constant muscle and joint pain, dysphoria or agitation.

Question 4

what are the drugs used to reverse opioids action ?

Answer 4

Methadone
Naltrexone
Buprenorphine

Question 5

what type of receptor the reverse opioids drugs work on ?

Answer 5

Mu type

Question 6

which of these drugs has longer duration of action ?

Answer 6

Buprenorphine

Question 7

which drugs I can alleviate opioids withdrawal symptoms and not approved by FDA ?

Answer 7

Clonidine

Question 8

what is the Mechanism of action of Clonidine ?

Answer 8

central alpha 2 agonist < activate vagal nerve thus decrease BP and heart rate

Question 9

in which situation Naltraxon is used ?

Answer 9

in opioids dependance it prevent relapses