Psychopharmacology Flashcards
An early report suggested that _______, an antitubercular agent, had mood-elevating properties in patients who had been treated for tuberculosis (Bloch et al. 1954).
iproniazid
Phenelzine, isocarboxazid, and tranylcypromine are _______ MAOIs. Selective or non-selective?
Non-selective
Selegeline is selective for _____ at lower doses.
MAO-B
MAO-A is present in both _______ and _____ neurons, whereas MAO-B is present to a greater extent in serotonin (5-HT)–containing neurons.
dopamine & norepinephrine; serotonin
The main substrates for MAO-___ are epinephrine, NE, and 5-HT.
MAO-A
The main substrates for MAO-____ are phenylethylamine, phenylethanolamine, tyramine, and benzylamine.
MAO-B
What rare, inherited disorder is caused by a mutation in MAO-A and is characterized by impulsive aggressiveness and mild menta retardation?
Brunner syndrome
Where in the cell is the MAO enzyme located?
outer surface of the plasma membrane of mitochondria
The antidepressant mechanism of MAOIs corresponds to . . .
reduction in the number of β-adrenoceptors, α1- and α2-adrenoreceptors, and serotonin type 1 (5-HT1) and serotonin type 2 (5-HT2) receptors
What is the likely reason that tranylcypromine produces stimulant-like effects in the brain?
structural similarity to amphetamine
Early studies suggest that MAOIs are more effective for ____ depression and TCAs more effective for _____ depression.
atypical; melancholic
What percentage of patients with panic disorder respond to irreversible MAOIs?
50-60%
In treatment of panic with MAOIs, patients often feel worse before they feel better. What is the typical clinical strategy to prevent this?
combining with benzo during early treatment
A meta-review noted evidence that MAOIs are superior to ____, but not ____, in treating atypical depression (Cipriani et al. 2007).
TCAs; SSRIs
MAOI treatment can cause myoclonic jerks, peripheral neuropathy, and paresthesias. To prevent, patients should be on _______.
pyridoxine
