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Psychopharmacology Flashcards

1
Q

1)Serotonin metabolized product
2)Norepinephrine metabolized product
3)Dopamine metabolites product

A

1)5 hydroxy indole amino acids
2)3 medroxy 4 hydroxy phenyl glycol
3)homo vallinic acid(HVA]

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2
Q

Antipsychotic drug another names are

A

D2 blockers/ dopamine blockers
Major tranquilizer [sedatives)
Antischizophrenic drugs
Neuroleptic drugs

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3
Q

DOC for resistance in schizophrenia

A

Clozapine

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4
Q

M/C drug used in schizophrenia

A

Olanzapine

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5
Q

DOC for denial for treatment In. Schizophrenia

A

Resperidone

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6
Q

DOC for reserve drug in schizophrenia

A

Clozapine

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7
Q

DOC for ICU psychosis

A

Haloperidol

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8
Q

DOc for pt come in emg with severe psychotic symptoms

A

Haloperidol

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9
Q

Which type of antipsychotic drugs cause more EPS

A

Typical antipsychotic drugs

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10
Q

Typical and atypical effect on blocks which neurotransmitters

A

Typical= dopamine block( treat only positive symptoms)
Atypical= dopamine + serotonin[treat both negative and positive symptomatic]

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11
Q

Examples of typical antipsychotic

A

Chlorpromazine haloperidol thirodizine

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12
Q

Examples of Atypical antipsychotic

A

Clozapine olanzapine resperidone

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13
Q

Which antipsychotic drug Causes fever

A

Chlorpromazine = acts on hypothalamus

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14
Q

Which antipsychotic drug causes maximum extrapyramidal effect

A

Haloperidol a/k/a serenac

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15
Q

Which antipsychotic drug had photosensitive as it’s sideffect

A

Thirodiazide[retinal pigmentation]

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16
Q

Who is the longest acting antipsychotic

A

Penfurinol(typical antipsychotic)

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17
Q

Which Atypical antipsychotic drug has agranulocystosi as.its side effects

A

Clozapinea/k/a suicidal drug and reserve drug and has minimum EPS

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18
Q

When to stop clozapine

A

W.BC less than 3000

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19
Q

Name the drugs causes agranulcytoiss

A

Clozapine
Carbamazapine
Prophill thiouracil[PTU]
Phenytoin

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20
Q

S/ E of olazapine

A

Obesity

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21
Q

S/E of quitipine

A

Cataract

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22
Q

What are two most common side effect of resperidone???

A

Arrhythmia and orthostatic hypotension

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23
Q

Why do extrapyramidal symptoms occur in antipsychotic drugs??

A

Dopamine.level drops and acetylcholine level increase

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24
Q

5 symptoms of extrapyramidal syndrome with it’s time of occurence

A

Acute dystonia[immediate occurence]
Pseudoparkinsonism[1-6 days occurence)[2nd priority]
Akathesia[50-60 days][1st priority]
Tradive dyspkinesia[late EPS but irreversible]
Neuroleptic malignant syndrome( rare and dangerous)

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25
What symptoms occur in acute dystonia
Occulogris crisis [upward eye movement],torticollis,facial grimace in this AcH level increase
26
DOC for acute dystonia
Diphenhydroxamine [ antihistamines] resume ACH levels
27
Neuroleptic malignant syndrome symptoms include
Fever (>38°C )[M/C] BP fluctuates Altered level of consciousness
28
Neuroleptic malignant syndrome symptoms include
Fever (>38°C )[M/C] BP fluctuates Altered level of consciousness Hyperreflexia
29
DOC for Neuroleptic malignant syndrome
Dentrolen
30
Drug of choice for EPS priority wise
1)benzotropine (anticholinergic) 2)trihexyphenidate(anticholinergic)
31
Antimaniac drugs another name
Mood stabilizing drugs and iodine drugs
32
Name of antimaniac drugs
Lithium carbonate (M/C) Lithium oxalate Valporic acid
33
Antimaniac drugs avoided in.pregnancy
1st priority = valporic acid 2nd = Lithium carbonate
34
Antimaniac drugs avoided in.pregnancy
1st priority = valporic acid 2nd = Lithium carbonate
35
Valporoc acid interfere with which drugsor nutrient absorption
Follic acid cause neural tube defects and teratogenic
36
DOC for Lithium resistant mania
Valporic acid
37
Which diagnostic evaluation is done in patient prior giving antimani drug valporic acid
LFT causes liver damage in patient
38
DOC for acute mania priority wise
1]haloperidol 2)benzodiazepam + lithium
39
What Is the loading and maintenance dose of lithium in patient
Loading dose 1200-1800 mg/ day Maintenance dose= 600- 1200 mg / day
40
What Is the loading and maintenance dose of lithium in patient
Loading dose 1200-1800 mg/ day Maintenance dose= 600- 1200 mg / day
41
As lithium has a very narrow therapeutic index when should we check its therapeutic. Level in blood??
12 hrs after giving medicine and best time is early morning before brkfast
42
S. Lithium level normal in blood
0.6-1.2 meq/l
43
Toxicity level of lithium in blood
>1.5 meq/l [1.5-2meq/l= mild toxicity= ataxia tremors and apathy] [2-2.5meq/l]=moderate toxicity =blurred vision, seizure,anorexia nausea vomiting] [>2.5]= severe toxicity =nystagmus =kidney function dcsreases, oliguria and coma
44
If lithium level is >4 meq Then treatment best for patient is
Dialysis
45
Which electrolyte monitoring is.must in lithium therapy.
Hyponatremia[ lithium bind to kidney receptor in place of sodium increase lithium level and causes toxicity and hyponatremia]
46
S/E of lithium most common to.least common
1) anorexia nausea vomiting 2) tremors LITHIUM leukocute count increase + TREMORS +HYPOTHYROIDISM +URINE OUTPUT INCREASE +IN PREGNANT MOTHER CONTRAINDICATIONS
47
Which drug is not given with lithium therapy
Diuretic not given
48
Which teratogenic effect is caused by lithium it's name??
Ebstein anomaly(box shape heart= tricuspid valve affect cause right ventricular hypertrophy in fetus)
49
Which organ lithium therapy most commonly affect and which organ least commonly affect
Kidney affected and liver affected
50
Which gland is affected by lithium therapy
Thyroid gland
51
How much water should be advised with lithium therapy and can be given with special drink
(2.5-3 liter water per day) And with juice
52
How much water should be advised with lithium therapy and can be given with special drink
(2.5-3 liter water per day) And with juice
53
For it's antimaniac action how many time does lithium therapy takes
7-14 days
54
Another name of antidepressants drugs
Mood elevators and thymoleptics
55
1st discover antidepressants
Imipramine by Thomas khan
56
Tyramine food is avoided with which class of antidepressants
MAOIs
57
Which antidepressants requires ecg monitoring
TCAs
58
Which antidepressants requires ecg monitoring
TCAs
59
M/C used antidepressants
SSRIs
60
Antidepressants used for enuresis and DOC for enuresis and which therapy used for enuresis
Imipramine and desmopressin and alarm therapy

Psychiatry (4 decks)

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