Psychopharm Flashcards
SSRI drugs
Fluoxetine
Sertraline
Citalopram
Escitalopram
Paroxetine
SSRI indications
MDD
GAD
SAD
PTSD
OCD
Panic Disorder
SSRI adverse effects
Insomnia
Nausea
Weight loss
Sexual dysfunction
Increased anxiety
TCA drugs
Amitriptyline
Imipiramine
The only indication for TCAs
MDD
Antidepressant drugs
Selective Serotonin Reuptake Inhibitors
Serotonin-Noradrenaline Reuptake Inhibitors
Tricyclic Antidepressants
Monoamine Oxidase Inhibitors
TCA moa
block:
- noradrenaline & serotonin reuptake
- muscarinic receptors
- histaminic receptors
- alpha-1 receptors
TCA adverse effects
arrythmias
cardiotoxicity
dry mouth
sedation
urinary retention
blurred vision
constipation
weight gain
Possible drug interaction with SSRIs
Warfarin
- SSRIs inhibit warfarin metabolism = more free warfarin = more bleeding
Why do patients on clozapine need regular WCC?
Risk of agranulocytosis
Common 2nd gen antipsychotic drug adverse effects
- weight gain (quetiapine & olanzopine
- agranulocytosis
- QT prolongation
- tardive dyskinesia
Common 1st gen antipsychotic drug adverse effects
- EPSEs
- hyperprolactinaemia
- skin reactions