Psychopathology Flashcards
Exam
Intellectual disability
Deficits determined by assessment
Deficits in adaptive functioning
Onset during developmental period
Level of severity
Mild, Moderate and Severe
Most common chromosomal causes
Down’s syndrome
Fragile X syndrome
Fetal Alcohol syndrome
Autism Spectrum Disorder (ASD)
Deficits in social communication
Restrictive or repetitive patterns
Deficits in adaptive functioning
ASD Levels
Level 1 requires support
Level 2 requires substantial support
Level 3 requires very substantial support
Prognosis Best
IQ over 70
Verbal before age 5
Absence of comorbid mental health issues
Frequencies
4 X’s more in males
Causes
Brain/neurotransmitter abnormalities
Structural abnormalities in cerebellum and amygdala
Lower than normal serotonin synthesis
ADHD
Inattention and hyperactivity and impulsivity persisting 6 months onset before age 12 Diagnosis requires at least 6 symtoms 0ver 17 requires 5 symptoms 2X's more common in males
ADHD brain abnormalities
Smaller than normal Prefrontal cortex Caudate nucleus Globus pallidus Corpus Callosum Cerebellum
Tic Disorders
“sudden, rapid, recurrent, nonrhythmic motor movement or vocalization
Tourette’s disorder
requires at least one vocal tic and multiple motor tics that may occur together or at different times, may wax and wane in frequency but have persisted for more than one year, and had an onset before 18 years of age
Tourette’s linked to
has been linked to dopamine overactivity, a smaller-than-normal caudate nucleus, and heredity
Treatment Tourette’s
Treatment may include an antipsychotic drug (e.g., haloperidol) and medication for comorbid conditions – e.g., serotonin for obsessive-compulsive symptoms and methylphenidate or clonidine for ADHD
Communication Disorders
Stuttering
Disturbance in normal fluency and time patterning of speech.
Specific Learning Disorder
Difficulties related to academic skills
5 to 15% have a specific learning disability
80% have reading disorder
dyslexia most common
Brief Psychotic Disorder (BPD)
Symptoms for at least one day but less than a month.
BPD Symptoms
Delusions, hallucinations or disorganized speech. Disorganized or catatonic behavior.
Schizophreniform Disorder
Symptoms for one month and less than 6 months.
Schizophreniform Disorder:symptoms
delusions, hallucinations or disorganized speech
or catatonic behavior and negative symptoms
avolition, alogia, anhedonia.
Schizophrenia
Symptoms for at least on month and less than 6 months.
Schizophrenia Symptoms
Delusions, hallucinations and disorganized speech for at least 6 months.
Schizophrenia etiology
Genetic factors and neurotransmitter abnormalities.
Schizophrenia concordance rates
Parent 6%
biological sibling 9%
Child with one parent with schizophrenia 13%
Dizygotic (fraternal twin) 17%
Child with two parents with Schizophrenia 48%
Monozygotic (identical twin) 48%
Schizophrenia neurotransmitters
dopamine, glutamate, and serotonin
Dopamine hypothesis of schizophrenia - high levels of dopamine or hyperactivity of dopamine receptors.
Positive symptoms due to dopamine hyperactivity in subcortical regions of the brain especially in striatal areas.
Negative symptoms due to dopamine hyperactivity in cortical regions especially the prefrontal cortex.
Schizophrenia Brain abnormalities
enlarged ventricles and hypofrontality
lower than normal activity in the prefrontal cortex
dysfunction in the temporal-limbic-frontal network causes the negative symptoms
Schizophrenia comorbidity
Anxiety disorders, obsessive compulsive disorder, tobacco use disorder
Onset, course and prognosis
Symptoms appear late teens and early 30’s.
Peak onset is early to mid 20’s for males
Late 20’s for females.
Psychotic symptoms decrease with age
Negative symptoms and cognitive symptoms persist
Better prognosis=female gender, acute and late onset of symptoms, comorbid mood symptoms especially depressive symptoms.
Predominately positive symptoms
anosognosia lack of insight to ones disorder is associated with non adherence to treatment and elevated risk for relapse.
Families high in expressed emotion are at risk for relapse.
Treatment
Antipsychotic medications, adjunctive medications, CBT
family psychoeducation and other interventions, assertive community treatment, supported employment and social skills training.
Schizoaffective disorder
requires concurrent symptoms of schizophrenia and a major depressive or manic episode for most of the duration of the illness, but with the presence of delusions or hallucinations for two or more weeks without mood symptoms.
Delusional disorder
the person have one or more delusions for a duration of at least one month and (b) the person’s overall functioning has not been markedly impaired except for any direct effects of the delusion
Delusional disorder subtypes
grandiose (the person believes he/she has great but unrecognized talent or insight); (c) jealous (the person believes his/her spouse or partner is unfaithful); (d) persecutory (the person believes he/she is being conspired against, spied on, poisoned, or maliciously maligned); and (e) somatic (the person’s delusion involves bodily functions or sensations).
Bi-Polar I
One manic episode followed by or preceded by major depressive or hypomanic episodes
Manic episode for at least one week
Depressive episode for at least two weeks
Bi-Polar II
One hypomanic and one depressive episode
Hypomanic must be at least a week.
Depressive episode for at least two weeks.
cyclothymic disorder
Periods of hypomania and depression that do not meet the criteria for hypmania or major depression.
Etilogy of Bi-Polar
heredity, neurotransmitter and brain abnormalities
strong genetic component
Identical twins .67 to .1
dizygotic twins .20
Neurotransmitters that have been linked to bipolar disorder include norepinephrine, serotonin, dopamine, and glutamate (Ayano, 2016), and structural and functional abnormalities have been found in several areas of the brain including the prefrontal cortex, amygdala, hippocampus, and basal ganglia
Treatment
pharmacotherapy may include lithium; valproate, carbamazepine, or other anticonvulsant drug; and/or a second-generation antipsychotic drug such as aripiprazole, olanzapine, or risperidone
Depressive Disorders
MDD 5 or more symptoms for at least two weeks.
one symptom being depressed mood and lost of interest and pleasure in most activities.
Persistent depressive disorder symptoms for at least two years in an adult and one year in a child.
disruptive mood dysregulation disorder 12 months with severe and recurrent temper outbursts
peripartum onset and with seasonal pattern
peripartum onset of symptoms during pregnancy
seasonal pattern temporal relationship between mood episodes and time of year.
Childhood
Rates similar for boys and girls
Rates for females increases during adolescence
Higher rates for females persists into adulthood 1.5 to 3x’s higher than males.