Psychopathology

Question 1

Demence precoce coined by __________

Answer 1

Benedict Augustin Morel

Question 2

Dementia precox coined by _________

Answer 2

Emil Kraeplin

Question 3

Schizophrenia coined by __________

Answer 3

Eugene Bleuler

Question 4

First person to rank symptoms that differentiated schizophrenia from other psychoses

Answer 4

Curt Schneider

Question 5

Criteria for schizophrenia

Answer 5

At least two of the following Delusions, Hallucinations, Disorganized speech, Disorganized behavior, Negative symptoms

At least one of two must be Delusions, Hallucinations, or Disorganized speech

Timing: > 6 months

Specifiers: current vs multiple episodes, severity (1-5), acute vs partial/full remission, with or w/o catatonia

Question 6

Increased risk of schizophrenia associated with ________

Answer 6

Advanced paternal age
Urban environment
Minorities
Winter months
Frontal/Temporal region
Global brain shrinking

Question 7

Early onset schizophrenia associated with ______

Answer 7

More severe negative and cognitive symptoms

Question 8

Pathophysiology of schizophrenia

Answer 8

Positive sx: increased dopamine in mesolimbic (VTA –> NAcc)
Negative sx: decreased dopamine in mesocortical, decreased acetylcholine, decreased glutamate

Question 9

Dopamine formation pathway?

Answer 9

Tyrosine –> DOPA –> Dopamine

Question 10

Dopamine stored in vesicles by binding to ______ receptor

Answer 10

VMAT2

Question 11

Dopamine is terminated via _______

Answer 11

DAT: presynaptic receptor that reabsorbs DA, very few DATs in prefrontal cortex

COMT

Question 12

Dopamine release?

Answer 12

Feedback inhibited via D2 presynaptic autoreceptors

Question 13

Structural changes in schizophrenia?

Answer 13

Global atrophy, primary frontal/temporal/hippocampal

Question 14

________ infections linked in utero to schizophrenia?

Answer 14

Influenza, chlamydia, T. gondii

Question 15

___% of individuals with schizophrenia will attempt suicide

Answer 15

50%

Question 16

Delusions based on _______ will linger after treatment but _______ less likely to be misinterpreted

Answer 16

Pre-existing misunderstanding, new info

Question 17

_______ symptoms predate positive symptoms

Answer 17

Cognitive

Question 18

Family members of individuals with schizophrenia more likely to have cognitive deficits in _______ and ________.

Answer 18

Memory, Processing Speed

Question 19

Patients with schizophrenia have ____ year decreased life expectancy.

Answer 19

10

Question 20

Death in schizophrenia most often due to _______

Answer 20

Heart disease