PSYCHO-PHARM Flashcards
CYP2D6
SSRIs: Fluoxetine (Prozac), paroxetine (Paxil)
SNRIs: Duloxetine (Cymbalta), Venlafaxine (Effexor)
Tricyclic: Amitriptyline (Elavil), clomipramine (Anafranil), desipramine (Norpramin), imipramine (Tofranil), nortriptyline (Aventyl, Pamelor)
Antipsychotics: Aripiprazole (Abilify), haloperidol (Haldol), perphenazine (Trilafon), risperidone (Risperdal)
Other: atomoxetine (Strattera), fluvoxamine (Luvox), tamoxifen (Nolvadex)
metabolizes codeine into morphine
Inhibitors of Cytochrome P 450 2D6:
CYP2C19
SSRI : citalopram (Celexa)
Tricyclics: amitriptyline, clomipramine, imipramine
Other: diazepam (Valium), phenytoin (Dilantin)
Inhibitors:
Chloramphenicol
Fluoxetine
Omeprazole , lansoprazole
Ticlopidine
Delavirdine
Fluvoxamine
Oral contraceptives
Topiramate
Efavirenz
Isoniazid
Oxcarbazepine
Voriconazole
Inducers of Cytochrome P-450 2C19
Ginko biloba
Rifampin
St John’s Wort
CYP1A2
Antidepressant : imipramine
Antipsychotics: clozapine (Clozaril), haloperidol, olanzapine (Zyprexa)
Other: fluvoxamine
CYP2C9
Antidepressants: Amitriptyline, fluoxetine
Other: Tamoxifen
Inhibitors: (toxicity)
Amiodarone
Fluconazole
Fluoxetine
Isoniazid
Paroxetine
Zafirlukast
Inducers (ineffectiveness):
Phenobarbital
Phenytoin
CYP3A4
Antipsychotics: Aripiprazole, haloperidol, quetiapine, (Seroquel), ziprasidone (Geodon)
Other: buspirone (Buspar), diazepam, tamoxifen
Inhibitors:
1. Erythromycin
2. Antifungal
3. Grapefruit
4. Antipsychotics; ~zodone; ~zole
Erythromycin
Fluconazole
Fluvoxamine
Grapefruit juice
Itraconazole
Ketoconazole
Nefazodone
Inducers:
Barbiturates
Phenytoin
Rifampicin
Carbamazepine
Oxcarbazepine
Topiramate
Felbamate
Hypericum
CYP2B6
Bupropion (Wellbutrin)
