Psychiatry (P4) Flashcards
Define an illusion.
Stimulus present but is misperceived.
Define an hallucination.
Stimulus is not present but there is a perception.
What are the terms for an hallucination just as you are going to sleep, and when waking up?
Hypnagogic (sleep)
Hypnopompic (waking)
What is a reflex hallucination?
When a stimulus in one sensory modality triggers a perception in another modality e.g. hear a sound and see a ghost.
What is an extracampine hallucination?
Perceiving something that is impossible e.g. hearing your deceased grandmother on mars.
What is the difference between an over-valued idea and a delusion?
Over-valued ideas are firmly held false beliefs but one can be reasoned out of them.
A delusion is a fixed false belief which one cannot be reasoned out of.
What is a Fregoli delusion?
Believing that various different people are the same person.
What is delusional perception?
When a perception triggers a delusional belief e.g. the traffic light signal was a sign from MI6.
Name three types of delusion/
Nihilistic Hypochondriacal Grandiose Fregoli Guilt Delusional perception
Name two kinds of thought disorder.
Insertion: external agent putting thoughts in my head.
Broadcast: People can hear my thoughts.
Echo: Hear their own thoughts said back to them.
Block: Train of thought/speech suddenly stops.
What is concrete thinking?
Rigid or literal thinking. Patients don’t grasp metaphor easily.
What is Knight’s move thinking (aka loosening of association)?
Where there is no link between what someone is saying.
(vs. Flight of ideas where you can still see the links).
What is circumstantiality?
When someone talks around a topic
What is perseveration?
When someone gives the same answer repeatedly to multiple questions.
In Schizophrenia what are Schneider’s 1st Rank symptoms?
[‘Have The Delusions Stopped’]
Hallucinations (typically auditory 3rd person)
Thought disorder e.g. insertion, broadcast etc.
Delusions e.g. delusional perception.
Somatic Passivity i.e. a sensation imposed by outside agent).
1+ for >1month = Dx
Give two examples of negative symptoms
Catatonic behaviour
Social withdrawal
Blunt affect
Apathy
Name a first generation antipsychotic. What receptors do they act on?
Haloperidol
Chlorpromazine
Block D2 receptors
What kind of side effects do 1st generation antipsychotics produce? Give 2 examples.
Extrapyramidal Side Effects
Akathisia (Restless legs)
Parkinsonism
Dystonia (twisting repeating movements)
Tardive Dyskinesia (jaw/face jerks).
What kind of patients should you avoid giving 1st generation antipsychotics to?
Patients with Parkinsons
Progressive Supranuclear Palsy
Lewy Body Dementia
CNS depression e.g. coma.
Name two 2nd generation antipsychotics. What receptors do they act on?
Risperidone Clozapine Olanzapine Quetiapine Aripiprazole
D2 + 5-HT2a
Give two side effects of 2nd generation antipsychotics
Weight gain [Olanzapine, Clozapine, Quetiapine].
Dyslipidemia [Olanzapine, Clozapine].
Hyperglycemia [Olanzapine, Clozapine]
Hyperprolactinemia [esp. Risperidone].
Agranulocytosis (reduction in granular leukocytes e.g. neutrophils). [esp. Clozapine]
Which antipsychotic is reserved for treatment resistant schizophrenia?
Clozapine
A patient presents with confusion, labile BP, hyperthermia, raised WCC and raised creatinine following treatment with antipsychotics. What is the most likely diagnosis? What is the treatment?
Neuroleptic Malignant Syndrome
Stop the antipsychotic
Supportive
What are the 4 Ps of the biopsychosocial model?
Predisposing
Precipitating
Perpetuating
Protective
What is Dysthmia? What is the treatment?
Sustained low mood for >2 years.
Treatment is an SSRI e.g. Fluoxetine + CBT.
What is Cyclothymia? What is the treatment?
Rapid (within hours/days) fluctuations between depression and HYPOmania.
Treatment: CBT + mood stabilisers e.g. Lithium or lamotrigine.
What is the difference between Bipolar I and II?
Bipolar I = Mania + Depressive episodes.
Bipolar II = Depression without mania (may have hypomania).
What is the difference between mania and hypomania?
Mania: Typically longer than a week and cannot function socially (50% become psychotic).
Hypomania: Shorter duration and can still function.
Define psychosis
When a person loses touch with reality e.g. hallucinations or delusions.
What is the treatment for mania?
Antipsychotic
Mood stabiliser e.g. carbamazepine or lithium
Can you take NSAIDs with Lithium?
Not advised. NSAIDs have been shown to reduce clearance of lithium which can potentiate its action.
Give an example of a Serotonin Noradrenaline Reuptake Inhibitor (SNRI)
Duloxetine
Venlafaxine
Give an example of a Tricyclic Antidepressant (TCA)
Amitriptyline
Nortriptyline
Name a monoamine oxidase inhibitor (MAOI)
Selegiline
(These are really only used as a last resort).
What kind of antidepressant is Mirtazapine?
Noradrenergic And Specific Serotonergic Antidepressant (NASSA)
Give two common side effects of antidepressants
Low libido Erectile Dysfunction Anxiety Dry mouth Insomnia Addiction
TCAs can produce anticholinergic side-effects (pro sympathetic). Name two of these effects.
[‘Can’t see, Can’t pee, Can’t spit, Can’t shit’]
Uveitis
Urinary retention
Dry mouth
Constipation
TCAs can also block alpha 1 adrenergic pathways and cause postural hypotension.
+block histamine pathways causing drowsiness.
Foods high in what amino acid can induce the “cheese effect” in patients talking SSRIs/MAOIs?
Tyramine
Strong cheese and cured meats.
A patient on SSRI switched to MAOI without stopping the SSRI and presents with confusion, hypertension, tremor, tachycardia, sweating and mydriasis (dilation). What is the likely diagnosis and treatment?
Serotonin Syndrome
Stop SSRI/MAOI
Cyproheptadine (5-HT2 antagonist).
Benzodiazepines.
Why are benzodiazepines such as diazepam (valium), lorazepam, and chlordiazepoxide not recommended for longer than 4 weeks?
Risk of addiction
What happens if you suddenly stop taking SSRIs?
Antidepressant Discontinuation Syndrome aka SSRI withdrawal.
Nausea, GI upset, Flu-like symptoms for up to 2 weeks.
What is a staggered overdose?
The cumulative effect of several overdoses over a short period of time which can be sufficient to kill the patient.
Name a mood stabiliser that is safe for pregnant women and one that is not safe
Safe: Carbamazepine or Lamotrigine.
Not Safe: Sodium Valproate (results in birth defects). Lithium can cause heart defects.
What does IAPT stand for?
What is it for?
Improving Access to Psychological Therapy
[Self referral service for depression and anxiety]
What support service is available for mental health issues affecting those between 4-18 years of age?
Child and Adolescent Mental Health Services [CAMHS]
Define delirium.
Acute confusional state
[Medical Emergency]
Name three things that can cause delirium
[PINCH ME]
Pain Infection Nutrition Constipation Hydration
Medical e.g. stroke/drugs
Environment
How do you treat delirium?
1st line: Verbal/non-verbal reorientation
2nd line: Low dose antipsychotic
NB: Benzos can make it worse! Only consider if patient is violent/uncontrollable.
What is paraphrenia?
Positive symptoms of schizophrenia (hallucination, thought disorder, delusions,, somatic passivity) without the negative. Mainly in older patients (>60yo).
How long can a person be detained under section 2 of the mental health act?
28 days maximum
[This cannot be renewed!]
[Sect 2 = ASSESSMENT]
NB: Treatment can still be administered under section 2.
What are the conditions that must be met for section 2 of the mental health act? (Who is required and what kind of patient?)
Patient must have a mental disorder which puts them or others at risk.
2 doctors (1 S12 approved). \+ Approved Mental Health Proffessional (AMHP).
How long can a patient be detained under section 3 of the mental health act?
6 months
[It can be renewed]
[Sect 3 = TREATMENT]
2 doctors (1 x S12 approved) \+ AMHP
What is section 4 used for under the mental health act?
How long can a patient be detained under this?
Emergency assessment (out-patients). For max 72 hours (cant be renewed).
This is for a doctor to detain an outpatient while you wait for the criteria for Section 2 to be met.
What is the difference between Section 5(4) and 5(2) under the mental health act?
5(4) Nurses
6 hour detention for in patients.
5(2) Doctors
72 hour detention for in patients.
What is the difference between section 135 and 136 in the mental health act?
135 = Police detention from home. 24hrs. Requires a court order.
136 = Police detention from a public place. 24hrs.
What are the CAGE screening questions? Name another alcohol screening tool
Ever thought of Cutting down?
Ever get Angry when questioned about drinking?
Ever feel Guilty about your drinking?
Ever needed an Eye-opener in the morning?
AUDIT
MAST
JELLINEK
SADQ (severity)
What are the alcohol limits for blood and breath?
Blood = 80mg/100ml Breath = 35ug/100ml
How many units of alcohol are recommended per week?
Max 14 units per week
Spread over >3 days.
What is the technical definition of binge drinking?
> 8U in a single session (Men)
> 6U (Women)
How much is one unit of alcohol in ml and g?
10ml
8g
How do you calculate Units?
Units = [ABV% x Vol (ml)]
1000