Psychiatry Genetics

Question 1

Huntingtons disease inheritance is …

Answer 1

Autosomal dominant (gene located on chromosome 4)

Question 2

phenomenon in which each generation develops a genetic disease at an earlier age is called

Answer 2

anticipation

Question 3

psychiatric symptoms of HD

Answer 3

Depression
Anxiety
Psychosis
Blunted affect
Compulsions
Suicidality
Aggression

Question 4

Cognitive symptoms of HD

Answer 4

decline in executive function

short and long term memory deficits

Question 5

Motor symptoms of HD

Answer 5

Rigidity
Choreiform movements
Writhing Movements
Gait disturbance

Question 6

Treatment for HD

Answer 6

Symptomatic (irreversible and unstoppable)

Question 7

Psychiatric symptoms of Alzheimer’s

Answer 7

psychosis
behavioural disturbance
cognitive decline

Question 8

Genetic risk of bipolar disorder

Answer 8

is greater with first degree relatives (e.g. siblings or children)
Recurrence in dizygotic twins = 14% + monozygotic twins = 57%

Question 9

HD triad

Answer 9

choreoathetosis (contractions + twisting), Dementia + psychosis

Question 10

Genetics of Alzheimer’s

Answer 10

association with chromosome 21 (gene for amyloid precursor protein)