Psychiatry Flashcards

1
Q

What are screening tools used for alcoholism?

A

CAGE - cut down, annoyed, guilty and eye-opener

AUDIT - Alcohol Use Disorders Identification Test

SADQ - Severity of Alcohol Dependence Questionnaire

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2
Q

Briefly outline the 6 key features of dependence syndrome

A
  1. Strong desire to take the substance
  2. Difficulties controlling substance-taking behaviour (onset, termination or amount of use)
  3. Tolerance
  4. Withdrawal symptoms
  5. Neglect of other pleasures
  6. Persistence despite evidence of harmful consequences
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3
Q

What are the main effects of opioids?

A

Euphoria and Analgesia

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4
Q

SE of opioids

A

Respiratory depression

Constipation

Reduced appetite

Low libido

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5
Q

What is a beneficial effect of buprenorphine?

A

Creates a ceiling effect - no additional effect above a certain drug dose (reduced overdose likelihood)

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6
Q

Psychological therapies for opioid misuse

A

CBT

Motivational counselling

Support Groups

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7
Q

What can occur in withdrawal of Benzodiazepines?

A

Withdrawal symptoms including rebound symptoms

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8
Q

Commonest drugs in anxiolytics and hypnotics class?

A

Benzodiazepines

barbiturates

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9
Q

Commonest drugs in the Stimulants class?

A

Amphetamines and cocaine

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10
Q

Which substances more commonly cause paranoia?

A

Stimulants and Alcohol

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11
Q

Clinical effects of stimulants?

A

Sympathetic: pupils dilate, tachycardia, increased alertness, dry mucus membranes

Overactivity and Insomnia

Mood swings

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12
Q

What neurotransmitters are affected by cocaine?

A

Dopamine - reward pathways leading to euphoria, pleasure and emotional ‘high’

Noradrenaline - sympathetic symptoms

Serotonin - increased confidence

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13
Q

What is Ecstasy/MDMA?

A

Hallucinogen with stimulant properties

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14
Q

What is negative and positive reinforcement in relation to addiction?

A

Negative - negative (withdrawal) symptoms encourages further substance use

Positive - positive and euphoric symptoms associated with the substance encourage further use

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15
Q

Clinical and Physical effects of ecstasy.

A

Clinical:
Positive mood
Euphoria, sociability and intimacy
Sensations of newly discovered insights and heightened perceptions

Physical:
Sympathetic
Bruxism (gurning)

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16
Q

Example of a hallucinogen and clinical effects.

A

LSD
Sympathetic followed up psychological:

Distortions and intensifications of sensory perception

Out-of-body experiences

Altered mood

17
Q

How does the dose affect symptoms of ketamine use?

A

Low - mood elevation

High - hallucinogenic similar to LSD

18
Q

What is Korsakoff’s Psychosis?

A

Amnestic-confabulation Syndrome:

Amnesia (anterograde and retrograde)
Confabulation
Lack of insight
Apathy

19
Q

What is Wernicke’s Encephalopathy?

A

Classical triad:
Ophthalmoplegia
Ataxia
Confusion

20
Q

At what point may delirium tremens occur?

A

48-72hrs after alcohol withdrawal

21
Q

When do symptoms typically peak and subside in acute alcohol withdrawal?

A

Peak after 2/7 and subside after 4-5/7

22
Q

How does delirium tremens differ to classical withdrawal symptoms?

A

Evidence of altered mental state in DT

e.g. hallucination, delusions, confusion, agitation

23
Q

When are alcohol withdrawal seizures likely to occur?

What type of seizure?

A

24-48hrs post withdrawal

Generalised tonic-clonic

24
Q

RF to consider admission for acute alcohol withdrawal.

A
  1. Age <18 years
  2. Lives alone (no support)
  3. Previous withdrawal seizures/DT
  4. Previous failed withdrawal
  5. Complications e.g. Wernicke’s
25
Q

Benzodiazepine typically used in alcohol withdrawal

A

Chlordiazepoxide 5-7/7

26
Q

What medication may protect against seizures and arrhythmias in delirium tremens?

A

Magnesium

27
Q

What is the threshold for offering community based alcohol withdrawal?

A

> 15 units consumed per day

> 20 on the AUDIT

28
Q

Medications that may aid alcohol abstinence

A

Acamprosate

Naltrexone

29
Q

Long term effects of heroin

A

Impaired decision making

Impaired behaviour regulation

Impaired responses to stressful situations

30
Q

Symptoms to heroin withdrawal

A
Restlessness
Insomnia
Myalgia
D&amp;V 
Cold flushes
31
Q

Long term risks of IVDU

A

Infection (including sepsis and cellulitis)

DVT

Abscess