Psychiatry Flashcards

1
Q

Define Neuroses

A

Mild mental illness with no organic cause that involves symptoms of stress but no loss of touch with reality

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2
Q

Define Psychosis

A

Severe mental disorder in which thoughts and emotions are so impaired that contact with external reality is lost

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3
Q

Define Illusion

A

Misinterpretation of actual external stimulus e.g. Hearing wind and thinking it’s a baby crying

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4
Q

Define Hallucination

A

Internal perception without corresponding external stimulus

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5
Q

Define pseudohallucination

A

False perception which is perceived as occurring as part of ones internal experience not as part of the external world

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6
Q

Define overvalued idea

A

Form of abnormal belief, reasonable and understandable but unreasonably dominates the persons life

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7
Q

Define thought echo

A

Auditory hallucination in which the content is the patients current thoughts

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8
Q

Define though insertion

A

Delusional belief that thoughts are being placed into the patients head

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9
Q

Define thought withdrawal

A

Delusional belief that thoughts are being taken from the patients head

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10
Q

Define thought block

A

Sudden break in the chain of though - may be explained by thought withdrawal

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11
Q

Define thought broadcast

A

Delusional belief that ones thoughts are readily accessible to others

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12
Q

Define concrete thinking

A

Loss of ability to understand metaphorical ideas and abstract concepts - literal thinking - seen in schizophrenia and dementia

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13
Q

Define circumstantiality

A

Disorder of form of thought where irrelevant details and digressions overwhelm direction of thought process - seen in mania and anankastic PD

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14
Q

Define Confabulation

A

Describing plausibly false memories for a period where the patient has amnesia - seen in Korsakoffs, dementia and following alcohol palimpsest

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15
Q

Define perseveration

A

Continuing with a verbal response or action which was initially appropriate but ceases to be so - seen in organic disease and occasionally schizophrenia

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16
Q

Define depersonalisation

A

Subjective experience which the patient feels unreal

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17
Q

Define psychomotor retardation

A

Decreased spontaneous movement and slowness in instigating and completing voluntary movements - depressive illness

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18
Q

Define made acts, feelings and drives

A

Delusional belief that ones free will has been removed and an external source is controlling feelings and actions

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19
Q

Define somatic passivity

A

Delusional belief that sensations are being imposed upon the body by outside forces

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20
Q

Define conversion

A

Development of features suggestive of physical illness but which are attributed to psychiatric illness rather than organic pathology

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21
Q

Define Dissociation

A

Separation of unpleasant emotions or memories from conscious awareness with subsequent disruption to the normal integrated functioning of consciousness and memory

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22
Q

Define mannerism

A

Bizarre and pointless repetitive movement

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23
Q

Define derailment

A

Break in chain of association between meaning of thoughts - connection not apparent to patient or examiner

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24
Q

Define obsession

A

Idea, image or impulse which is recognised as the patients own but is repetitive, intrusive and distressing - can be resisted at the expensive of mounting anxiety, sometimes relieved by associated compulsions

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25
Q

Define compulsion

A

Behaviour or action which is recognised as unnecessary and purposeless but cannot be resisted - need to perform act in order to avoid adverse event

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26
Q

Define akathisia

A

Subjective sense of uncomfortable desire to move, relieved by repeated movement, usually the legs. Side effect of neuroleptics

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27
Q

Define clang association

A

Connection between words is based on sound rather than meaning e.g. Rhyming. Seen in manic flight of ideas

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28
Q

Cotard syndrome

A

Psychotic depressive illness characterised by triad of depressed mood, nihilistic delusions and hypochondriacal delusions

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29
Q

Couvade syndrome

A

Conversion symptoms mimicking pregnancy in the partner of a pregnant woman

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30
Q

Define delusion

A

A fixed unshakeable belief held outside of social and cultural norms despite lack of evidence

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31
Q

Delusion of jealousy

A

Partner being unfaithful, monosymptomatic = Othello Syndrome

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32
Q

Fregoli Syndrome

A

Strangers are familiar people

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33
Q

Capgras Syndrome

A

Delusional belief that familiar people have been replaced by identical strangers

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34
Q

Define Ekbom syndrome

A

Monosymptomatic delusion of infestation

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35
Q

Define De Clerambault syndrome

A

Female (usually) believes a higher status individual is in love with them and soften accompanying persecutory delusion that people are conspiring to keep them apart

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36
Q

Define delusions of reference

A

Belief that external events or stimuli have been arranged in a way such that that have a particular significance, or convey a message, to the individual

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37
Q

Define grandiose delusions

A

Beliefs that one has special powers or is unusually rich or powerful

38
Q

3 example of SSRI’s

A

Sertraline, citalopram, fluoxetine

39
Q

3 indications for SSRI’s

A

Depression, panic disorder, obsessive compulsive disorder

40
Q

What is the mechanism of SSRI’s?

A

Inhibit neuronal reuptake of serotonin from the synaptic cleft therefore increasing its availability for transmission

41
Q

Common side effects of SSRI’s

A

GI upset, appetite and weight changes, suicidal thoughts and behaviours (first 2 weeks)

42
Q

2 examples of tricyclics

A

Amitriptyline, lofepramine

43
Q

2 indications for tricyclics

A

2nd line for mod/severe depression, neuropathic pain

44
Q

How do tricyclics work?

A

Inhibit neuronal reuptake of serotonin and noradrenaline

45
Q

Which receptors do tricyclics also block?

A

Muscaranic, histamine (H1), a-adrenergic (A1 + A2), dopamine (D2) - extensive adverse effects

46
Q

Common side effects of tricyclics

A

Cholinergic - dry mouth, constipation
H1 + A1 - sedation, hypotension, weight gain
Arrhythmias, prolonged QT, QRS
Dopamine - sexual dysfunction

47
Q

Why shouldn’t you give antidepressants alongside monoamine oxidase inhibitors?

A

Risk of serotonin syndrome

48
Q

What class of drug is venlafaxine?

A

Serotonin and noradrenaline reuptake inhibitor - like TCA but less side effects

49
Q

What are the side effects of venlafaxine?

A

Cardiac, need to control BP, contraindicated if previous MI

50
Q

How does mirtazapine work?

A

Increases availability of monoamines for neurotransmission, s/e are dose dependent with sedation more prominent at a low dose and weight gain

51
Q

3 examples of typical (1st gen) antipsychotics

A

Haloperidol, Chlopromazine, Prochlorperazine

52
Q

4 indications for 1st gen antipsychotics

A

Severe psychomotor agitation
Schizophrenia where 2nd gen are unsuitable
Bipolar disorder - acute manic/hypomanic episode
Nausea and vomiting in palliative care

53
Q

What is the mechanism of 1st gen antipsychotics?

A

Blocks post synaptic dopamine (D2) receptors in mesolimbic/mesocortical pathway

54
Q

Side effects of 1st gen antipsychotics

A
Extrapyramidal effects 
Acute dystonic reaction (hours/days)
Akathisia (hours/days - treat with BDZ)
Tardive dyskinesia - years 
Drowsiness, hypotension, ED, menstrual disturbance, galactorrhoea
55
Q

4 examples of atypical antipsychotics (2nd gen)

A

Quetiapine, risperidone, olanzapine, clozapine

56
Q

3 indications for 2nd gen antipsychotics

A

Schizophrenia when s/e from 1st gen or negative symptoms
Psychomotor agitation
Acute manic/hypomanic episode

57
Q

How is the mechanism for 2nd gen antipsychotics different from 1st gen?

A

Lower risk of extrapyramidal s/e, looser binding to D2 receptors, higher affinity for other receptors

58
Q

Adverse effects of 2nd gen antipsychotics

A

Sedation
Metabolic disturbance - weight gain, diabetes, lipid changes
Arrhythmias
Breast changes and sexual dysfunction
Clozapine - agranulocytosis/myocarditis - regular blood checks

59
Q

5 examples of benzodiazepines

A

Diazepam, lorazepam, chlordiazepoxide, midazolam, temazepam

60
Q

5 indications for BDZs

A
Seizures and status epilepticus
Alcohol withdrawal
Sedation
Short term anxiety relief
Short term insomnia relief
61
Q

Adverse effects of BDZs

A

Dose dependent drowsiness, coma, sleepiness
Airway obstruction and death
Dependence -> withdrawal similar to alcohol

62
Q

Indications for lithium

A

Prophylaxis for bipolar disorder

Acute mania

63
Q

Side effects of lithium

A

GI upset
Tremor, ataxia, dysarthria
Polyuria, long term use renal damage
Thyroid enlargement

64
Q

What needs to be monitored in a patient on lithium treatment?

A

U+Es, thyroid function tests, lithium levels (every 3/12)

65
Q

Define reflex hallucination

A

Stimulus in one modality experienced in another

66
Q

Define hypnopompic hallucination

A

Hallucination phone waking

Hypnogognic - hallucination before falling asleep

67
Q

Peak incidence of schizophrenia

A

18-25 in men

25-30 in women

68
Q

Symptoms in the prodromal period of schizophrenia

A

Depression, anxiety, social withdrawal, self neglect, loss of interest

69
Q

Genetic risk if both parents have schizophrenia?

A

45%

70
Q

4 predisposing factors for schizophrenia

A

Increased stress
Increased emotion - positive or negative
Increased criticism
Drugs - alcohol and cannabis

71
Q

6 positive symptoms of schizophrenia

A
Auditory hallucinations
Thought disorder
Incongruity of affect
Mannerisms
Passivity 
Catalonia
72
Q

What are the negative symptoms of schizophrenia?

A

Lead to reduced functioning and are a poor prognostic sign, often difficult to distinguish from depression (weight, sleep and guilt/hopelessness are absent)
Alogia, blunting of affect, poverty of content of thought, abolition, slowness of though and movement

73
Q

What are the first rank symptoms of schizophrenia?

A

Delusions
Thought disorders (insertion, withdrawal, broadcast)
Auditory hallucinations

74
Q

How would you investigate a potential case of schizophrenia?

A
Drug screening
EEG - epilepsy
Fasting glucose - diabetes
Neuro exam - organic cause
Bloods - baselines before starting meds
CT/MRI - SOL
75
Q

Management of schizophrenia

A
Based on risk - detained under MHA---managed at home 
Antipsychotics
Clozapine for treatment resistant 
Psychotherapists help negative symptoms 
Social care
76
Q

3 risks of a patient with schizophrenia

A

To self -
Suicide
Self neglect

To others -
Children, public, partner (delusional jealousy)

77
Q

Mental health act section 2

A
To assess
Up to 28 days
Signed by 2 doctors and social worker 
1 dr to know patient
Treatment can be given against will
78
Q

Mental health act section 3

A

Up to 6 months
Can be renewed
Treatment for 3 months then must consent or 3rd dr to approve

79
Q

Section 135

A

Police can remove person to place of safety for 72 hours
Can use force
If social worker has obtained warrant
Cannot treat

80
Q

Section 136

A

Don’t need warrant
Can remove from public place
Cannot treat

81
Q

What is the upper limit for lithium

A

1.2mMol/L

82
Q

Side effects of lithium therapy

A

Fine tremor, hypothyroidism, T wave, widening of QRS

83
Q

Symptoms of lithium toxicity

A

Early - coarse tremor, GI upset, dehydration

Later - hypertonicity, ataxia, drowsiness

84
Q

Management of lithium toxicity

A

Education, dose adjustment, forced diuresis, IV isotonic saline, haemodialysis

85
Q

What is neuroleptic malignant syndrome?

A

Rare but life threatening idiosyncratic reaction to anti psychotics

86
Q

Symptoms of NMS

A
Fever
Autonomic instability 
Leucocytosis
Tremor
Elevated CK
Rigidity
 Can cause rhabdomyolysis, seizures, resp failure
87
Q

How would you treat NMS?

A

BDZs for behaviour, Dantrolene for muscle spasms, hydration and alkalisation of urine if rhabdomyolysis (IV sodium bicarbonate)

88
Q

Describe acute dystonic reaction

A

Painful muscle spasms producing repetitive, twisting movements which develop following exposure to antipsychotics (48hours-1week)

89
Q

Symptoms of serotonin syndrome

A

Altered mental state, agitation, tremor, shivering, hyperreflexia

90
Q

Treatment of serotonin syndrome

A

If overdose - gastric lavage/activated charcoal
IV access to allow volume correction and reduce risk of rhabdomyolysis
Resolves in 24/36 hours

91
Q

What drugs can cause serotonin syndrome

A

Amfetamines, SSRIs, MAOIs, TCAs, lithium

92
Q

3 differences between NMS and serotonin syndrome

A

Onset
NMS days to weeks
SS rapid

Activity
NMS bradykinesia
SS hyperkinesia

Progression
NMS 24-72 hours
SS rapid

Rigidity
NMS lead pipe, severe
SS less severe