Psychiatry Flashcards
Delirium-DSM 5
A. Disturbance in attention and awareness
B. Disturbance develops over a short period of time, represents a change from baseline, and tends to fluctuate in severity over the course of a day
C. Additional disturbance in cognition (memory deficit, disorientation, language, visuospatial ability/perception).
D. Does not occur in the context of a severely reduced level of arousal (coma)
E. Evidence of physiological consequence as the cause
Causes of Delirium
- Substance Abuse
- Substance Withdrawal
- Medication-Induced
- Due to another medical condition
- Due to multiple etiologies
- Nutritional deficiencies
- Anemias
- Electrolyte imbalance
- Low ACh (Anticholinergics)
- High DA (Opioids)
Clinical Findings in Delirium
- Acute onset
- Inattention
- Disorientation
- Fluctuation of mental status
- Memory impairment
Pathophysiology of Delirium
- Inflammation (pro-inflammatory cytokines)
- Stress Rxn
- High coritsol
- Sleep deprivation
- Neuronal injury
- Disrupts BBB
- Neurotransmission abnormalities
- Decreased ACh
- Increased DA
Precipitating Factors of Delirium
- Medications: Anticholinergics/Opioids
- Hypoxia
- Hypoglycemia
- Hyperthermia/Fever
- Infection
- Metabolic Abnormalities
- Hypoalbuminemia (early sign)
Factors to reduce frequency of delirium
- Orientation protocol (write day/date/location/ID in sight)
- Noise reduction
- Visual aids
- Hearing aids
- Hydration
- Early mobilization
Drug Treatments for Delirium
- Benzodiazepines IF caused by withdrawal of ETOH or Benzodiazepines
- Pro-cholinergic drugs (AChE Inhibitors)
- DA antagonists (antipsychotics)
Major vs Minor neurocognitive disorder
Major: Substancial cognitive decline that interferes with independent living
Minor: Modest changes in cognition that do not yet interfere with independent living
Examples of major neurocognitive Disorders
- Alzheimer’s
- Vascular disease
- Prion Disease
- Parkinson’s
- Huntington’s
Changes in the brain in Alzheimer’s patients
- Amyloid plaques (beta amyloid peptides)
- Neurofibrillary tangles (tau protein)
- Loss of connections/cell death
- Loss of ACh
Symptoms of Alzheimer’s
- Memory loss***
- Loss of recognition
- language problems
- Anterograde amnesia
Drugs that treat alzheimer’s
- AChE inhibitors (inhibit ACh breakdown)
- NMDA antagonists
Risk Factors for Alzheimer’s
- Age
- Genetics for early-onset (chromosomes 1, 14, 21)
Most common cause of amnestic disorder
Alcohol abuse with chronic thiamine (B-1) deficiency
Symptoms of Wernicke’s Encephalopathy
- Ophthalmoplegia
- Ataxia
- Mental confusion
Symptoms of Korsakoff’s psychosis
- Amnesia (retrograde or anterograde)
What are the six cognitive domains in neurocognitive disorders?
- Attention
- Executivefunction
- Learning and memory
- Language
- Perceptual motor
- Social-cognition
Difference between Hallucination and Illusion
- Hallucination: seeing something that isn’t there (any of the 5 senses)
- Illusion: seeing something that is there but thinking that it is something else (see a rope but think it is a snake)
Mood vs Affect
- Mood: emotional attitude that is relatively sustained, self-reported
- Affect: the way the patient conveys their emotional state as perceived by others (how a patient “appears”)
Tegmentum: origin of which neurotransmitter?
Dopamine
Raphe nucleus: origin of which neurotransmitter?
Serotonin
Locus Ceruleus: origin of which neurotransmitter?
Norepinephrine
Tuberomammiliary nucleus: origin of which neurotransmitter?
Histamine
Nucelus Basalis of Meynert: origin of which neurotransmitter?
ACh
Neurotransmitter mediating executive function, motivation,interpersonal and emotional behavior
Glutamate
Function of DA
Attention
Pleasure
Motivation
Function of NE
Energy
Alertness
Concentration
What part of the brain atrophies in depression?
Hippocampus
What are the changes in DA transmission in Schizophrenia?
-
Decreased in prefrontal cortex
- Due to excess stimulation of serotonin receptors on presynaptic neuron
-
Increased in Mesolimbic cortex
- Inhibition of serotonin receptors on presynaptic neuron
Results of Glutamate Hypoactivity in the brain in Schizophrenia
- Decrease DA downstream
- if glutamate neuron directly connected to DA neuron
- Prefrontal cortex in Schizophrenics
- leads to negative symptoms (mood and cognitive)
- Increase in DA downstream
- connected to DA neuron through a GABA interneuron
- Mesolimbic system in Schizophrenics
- Leads to psychotic symptoms
Pavlovian conditioning definition
Pairing of stimuli
Operant conditioning definition
Positive reinforcement vs negative reinforcement where behavior can control its own consequences
Unpredictable schedule of reinforcement works best
Behavioral therapy moto
work on observable behaviors, feelings to follow
Types of behavioral therapy
- Relaxation training
- Exposure
- Flooding
- Behavioral Activation
- muscle relaxation to achieve control over feelings of tension and relaxation
- imaginary or in vivo; gradual exposure to more and more fearful things; systematic desensitization
- Constant exposure to most feared thing; Not used
- Re-Engage person in social activities
What is a cognitive schema?
How you have learned to think
What is the cognitive triad and in what disorder is it mostly found?
- Negative view of self
- Negative view of future
- Negative interpretation of experience
Found in depression
What is arbitrary inference?
Drawing an erroneous conclusion from an experience
What is Selective abstraction?
Taking a detail out of context and using it to denigrate the entire experience
What is overgeneralization?
Making general conclusions about overall experiences and relationships based on a single instance
What is magnification and minimization?
Altering the significance of specific events in a way that is structured by negative interpretations
Ex: a good grade explained by the test being easy but a bad grade being attributed to being a terrible student who will never succeed in life
What is personalization?
Interpreting events as reflecting on the patient when they have no relation to him or her
Ex: a frown from a grouchy traffic policeman is seen as recognition of the patient’s overall lack of skill as a driver and general worthlessness
What is Dichotomous thinking?
Seeing things in an all-or-nothing way
Ex: An A- student gets a B in a course and concludes that it proves that they are a terrible student
What is free association?
In psychoanalytic therapy, spontaneous, uncensored verbalization by the patient of whatever comes to mind.
What is Transference?
In psychoanalytic therapy, feeling something toward the analyst that stems from a feeling toward someone else/an experience in life.
What is Couter-transference?
In psychoanalytic therapy, the transference/emotional reaction by the analyst of previous experience and feelings onto the patient
What is transference neurosis?
In psychoanalytic therapy, fully developed transference of the role of someone in the patient’s life to the analyst
What is projection?
A defense mechanism in which the feelings one feels toward another is viewed as being felt by the other person towards oneself.
Ex: I have negative feelings toward you but think you don’t like me
What is Splitting?
A defense mechanism in which the self or others are viewed as all good or all bad, with failure to integrate the good and bad qualities into a cohesive image.
The person alternatively idealizes and devalues the same person.
What is dissociation?
A defense mechanism consisting of an altered state of consciousness; separation of an idea from its emotional significance
What is Reaction formation?
A defense mechanism in which a person adopts affects, ideas, and behaviors that are opposites of impulses harbored either conscously or unconsciously.
Ex: excessive moral zeal may be a reaction to strong but repressed asocial impulses.
What is intellectualization?
A defense mechanism in which the person engages in excessive abstract thinking to avoid confrontation with conflicts or disturbing feelings.
What is sublimation?
A defense mechanism by which instinctual drives, consciously unacceptable, are diverted into personally and socially acceptable channels.
Ex: feeling agression toward someone so you beat them at a game rather than physically
Focus of insight-oriented psychotherapy
interpersonal relations in the present and intellectual understanding
Focus of interpersonal therapy
ID and work on problem areas that ma affect self esteem and interactions
Characteristics of Atypical Depression
- Mood reactivity
- Leaden paralysis (arms and legs)
- Weight Gain, Excessive sleep
- Treat w/MAOIs
Characteristics of Melancholic Depression
- Guilt
- Terminal insomnia
- Anorexia
Characteristics of SAD
Depressed mood coincides with particular seasons
Spring-onset: more sever, higher risk of suicide
Fall-onset: rull remission in the summer months
Characteristics of Persistent Depressive Disorder
- Longer duration and persistance (2 years)
- Less severe symptoms
- 2 symptoms of depression persist for 2 years
Characteristics of Psychotic Depression
- Mood-congruent delusions
More common in bipolar psychosis than unipolar
Treat with antidepressant + antipsychotic