Psychiatry Flashcards
What components are in a formulation?
- predisposing
- precipitating
- presenting
- perpetuating
- protective
What is included in an MSE?
A - appearance and behaviour
S - speech
E - emotion
P - perception
T - thought
I - insight
C - cognition
What is the definition of mental health disorder?
Disorder of mind excluding alcohol and drugs
What is the definition of psychosis?
Loss of touch with reality + impaired function
What is the definition of a hallucination?
An unreal interpretation of an unreal stimulus (e.g. hearing voices)
What is the definition of an illusion?
An unreal interpretation of a real stimulus (e.g. leaves rustling mistaken for footsteps)
What is a delusion?
A fixed false unshakeable belief out of keeping with social norms
What is the definition of delusional perception?
‘If A happens, B will happen’ (pathognomonic for schizophrenia)
What is the definition of flight of ideas?
Rapid stream of consciousness - jump between topics
What is the definition of formal thought disorder?
Disordered pattern of speech as a result of disordered thought
What is the definition of knight move?
Illogical jumps from a point and not returning
What is the definition of tangeniality?
Deviating from a point and not returning
What is the definition of circumstantiality?
Deviating from a point but returns
What is the definition of depersonalisation?
When someone thinks there not real
What is the definition of derealisation?
When someone thinks the world around them isn’t real
What is the definition of obsession?
Mental preoccupation, pervasive and recurrent
What is the definition of compulsion?
Urge + action or obsession to obtain relief
What are some of the thought problems patients experience?
- Insertion
- withdrawal
- broadcast
- passivity
What is somatoform disorder?
Medically unexplained symptoms
What is hypochondriasis?
Mental preoccupation that a patient has a life threatening illness despite a lack of symptoms and negative tests
What is conversion disorder?
Neuro symptoms (e.g. weakness) in absence of pathology therefore put down to psych
What are some of the types of delusion?
- persecutory - mc
- grandiose
- guilt + worthlessness
- nihilistic
What is Capgras delusion?
The belief that a close relative has been replaced with an imposter
What is Fregoli delusion?
The belief that everyone is one person with masks
What is Othello delusion?
The belief that their partner is unfaithful (extreme jealousy)
What is de clerambault delusion?
The belief that a exalted yet inaccessible person is in love with the patient
What is Ekbom delusion?
Restless leg syndrome, painful calf cramping, “creepy crawly”
What is Cotard delusion?
The belief that the patient is dead and rotting
How long do antidepressants take to start working?
4-6 weeks
What is there an increased risk of in under 30s starting antidepressants?
Increased suicide risk
How long do antidepressants need to be taken after symptoms improve?
Keep taking for 6 months after symptoms improve and then wean over 4 weeks - prevents serotonin discontinuation syndrome
What are the symptoms of serotonin discontinuation syndrome?
- nausea + vomiting
- agitation
- insomnia
- paraesthesia
- flu like symptoms
According to the MHA 1983 what do you need to be able to detain a patient?
- Evidence of a mental health illness
- They’re going to be a risk to society
- They will benefit from admission
- There is treatment available for them
What are the principles of the MHA 1983?
- need to pick the least restrictive option available
- patient needs to be safe
- improve patient wellbeing ‘
- give effective treatment
True or false: the MHA can override the MCA?
True
What is the most commonly used SSRI?
Sertraline
What are some available SSRIs?
- Sertraline
- Paroxetine
- Fluoxetine
- Citalopram
Which SSRIs can be used when breastfeeding?
Paroxetine and fluoxetine
Which SSRI is most likely to cause QTc prolongation on an ECG?
Citalopram
What are some of the side effects of SSRIs?
- GI - n+v, pain, increased GI bleed risk
- Impotence and decrease libido
- Serotonin syndrome
- QTC prolongation
- Hyponatremia
What medications can SSRIs interact with?
- Triptans - decrease the efficiency
- NSAIDs - GI bleeds, co-prescribe a PPI
What congenital defects can paroxetine cause in the first trimester?
- Congenital heart defects
- Cleft palate
What congenital defects can paroxetine cause in the third trimester?
Persistent pulmonary hypertension of the newborn
What are some examples of SNRIs (antidepressants)?
- Venlafaxine
- Duloxetine
What are some side effects of of SNRIs?
- Nausea and vomiting
- dry mouth
- rhabdomyolysis
- SIADH
What are some examples of tricyclic antidepressants?
- amitriptyline (sedating)
- imipramine (non sedating)
What are the side effects of tricyclic antidepressants?
- Dry eyes, mouth, dehydrated, constipation
- impotence
- sedation
What are the side effects for overdosing on tricyclic antidepressants?
- Dry hot skin
- confusion
- Increased acetylcholine symptoms
How is a tricyclic antidepressant overdose diagnosed?
ECG - Wide QRS + QTC prolongation
How is a tricyclic antidepressant overdose treated?
IV Bicarb
What are the side effects of mirtazapine?
- weight gain
- sedation
What is first line for depression if a patient is on warfarin or LMWH?
mirtazapine
What are the symptoms of major serotonin syndrome?
- Hyperreflexia
- ankle clonus
- dilated pupils
- autonomic symptoms
- maybe increased creatinine kinase
What is the treatment for serotonin syndrome?
Stop SSRI and give chlorpromazine
How should antipsychotic medications be stopped?
Gradual reduction when stopping (over 3 months) to prevent relapse
What is checked at the 12 monthly review for a pt on antipsychotics?
FBC, U+E, HbA1C, LFT, prolactin, BMI
What are typical antipsychotics?
Haloperidol and chlorpromazine
What are the side effects of typical antipsychotics?
- Acute dystonic reaction
- Akathisia - Lower leg motor restlessness
- Parkinsonism
- Tardive dyskinesia - years after
- lactation
- decreased libido
- infertility
What are atypical antipsychotics?
Risperidone, olanzapine, quetiapine, aripiprazole, clozapine
What are atypical antipsychotics associated with?
- Weight gain
- Metabolic syndromes - T2DM, Cushings
When will clozapine be used on a patient?
When 2 different antipsychotics have been tried
When are patients on clozapine monitored?
- First 18 wk - weekly
- Then fortnightly for 16 wk
- Then monthly
- Monitor - FBC, BP, BMI, SE
Which antipsychotic is proven to work on the mesocortical pathway and the mesolimbic pathway?
Clozapine
What are the main side effects of clozapine?
- Agranulocytosis
- Hypersalivation
- Weight gain
- Constipation
What needs to happen if a patient on clozapine misses a dose for more than 48hr?
Need to retitrate their dose - start on lower and work way back up
What needs to happen if a patient on clozapine’s smoking status changes?
Need to retitrate their dose - smoking decreases bioavailability of clozapine
What causes major neuroleptic malignant syndrome?
Overuse of antipsychotic or hypersensitivity reaction to antipsychotic
What are the symptoms of major neuroleptic malignant syndrome?
- Hyporeflexia
- Rigidity
- Normal pupils
- Raised creatine kinase +/- raised WCC
What is the treatment for major neuroleptic malignant syndrome?
Stop the antipsychotic, give dantrolene IM and bromocriptine
What are the complications of major neuroleptic malignant syndrome?
- Rhabdomyolysis
- AKI due to acute tubular necrosis
What is lithium used for?
Mood stabiliser - acts on cAMP
What medication does lithium interact with?
- NSAIDs
- diuretics
- ACE inhibitors
What side effects can lithium cause?
- Dehydration
- renal failure
- lithium toxicity
What level of serum lithium in the blood is classed as lithium toxicity?
> 1.5mmol/l
What are the symptoms of lithium toxicity?
- Leucocytosis
- diabetes insipidus
- tremor - coarse
- dehydration
- hypothyroidism
True or false: lithium is teratogenic?
True
When are you going to measure lithium levels in a pt?
- 12hr post first dose
- weekly till stable
- 3 monthly
What are you going to monitor on patients on lithium?
FBC, U+E, TFT, eGRF, BMI, ECG
What are the symptoms of syndrome of irreversible lithium effectuated neurotoxicity?
- cerebellar symptoms
- dementia
- parkinsonism
- dystonia
- akathisia
If lithium cannot be used as a mood stabiliser what else can be?
- carbamazepine
- valporate
What are benzodiazepines used for?
sedation, alcohol withdrawal, anxiety
What are some examples of benzodiazepines?
chlordiazepoxide, diazepam, lorazepam
When would ECT (electroconvulsive therapy) be used?
In severe refractory depression and severe mania and sometimes catatonic schizophrenia
What are the complications of ECT?
- Amnesia (short term)
- Confusion (long term)