Psychiatry Flashcards

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1
Q

Describe sectioning

A

Sectioning under mental health act used when the patient is suffering from a mental health disorder, poses a risk to their own or other’s health (or there are previous patterns of deterioration to the point of risk) and all other options have been explored
Sectioning requires an AMHP and 2 doctors (1 section 12 trained, do not work with each other, know the patient). At any point they have right to tribunal review
Sections: 2 - assessment (no treatment) for 28d, 3 - assessment and treatment up to 6m, 5.2 - holding powers for 72h (already in hospital, no treatment), 5.4 - nurse holding powers 6h, 136 - police detained from public place, 135 - police from home

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2
Q

Describe a mental state examination

A

Appearance and behaviour: clothing, hygiene, body language, eye contact, weight, physical signs
Motor: agitation, psychomotor retardation, catatonia, extra pyramidal side effects, tics, tremor
Speech: spontaneous, brief vs prolonged, rate + pressure (can interrupt?), volume, rhythm, tone, clanging (how it sounds over sense - rhyme etc)
Mood and affect: subjective and objective, congruity, range of emotions
Mood = climate, weather = affect (how they are immediately observable, expression)
Thinking: form (structure of sentences), content (delusions), mood congruent?, obsessions / compulsions, depersonalisation, intrusive thoughts, depressive, perception / hallucinations / illusions
Withdrawal, insertion, derailment, flight of ideas + tangential, thought blocking, broadcasting, circumstantial (too much detail)
First rank (schizophrenia): special type auditory hallucinations (3rd person, running commentary, thought echo), delusions of thought interference (withdrawal / insertion / control), passivity phenomena (thoughts + actions out of their control), delusional perception
Types of delusion: capgras - friend or pet replaced by identical imposter, fregoli - someone you know in disguise, cotard - you are missing body parts / dead, de clerambault - erotomania
Cognition: orientation, attention (months backwards) + concentration, memory
MoCA, MMSE
Insight: how aware they are of being ill, do they want help
Risk: to themselves - self neglect, to others MOST IMPORTANT

Remember as ASEPTIC(R): appearance (+ behaviour), speech, emotions, perception, thoughts, insight, cognition, risk

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3
Q

What extra information needs to be included in a history

A

History also needs to include: full exploration of presenting complaint and check for other symptoms, suicide / self harm risk, personal circumstances, upbringing / childhood, forensic, premorbid personality, alcohol + drugs, risk to others

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4
Q

Describe delusions and hallucinations

A

Delusions - fixed, false / illogical, out of sociocultural norms: persecutory - going to be harmed / harassed / conspired against; grandiose - self importance + special; erotomanic - someone is in love with them, often higher status; jealous - partner is being unfaithful; somatic - something about their body / health; nihilistic - nothing matters, there is no future, often at least part of them is dead

Hallucinations - sensory perception without stimulus, are experienced as one of the 5 senses, auditory then visual are the most common. Most common causes of hallucinations are schizophrenia, parkinson’s, alzheimer’s (Lewy body), migraine, tumour, Charles Bonnet (poor vision)
Illusion - incorrect perception of stimulus

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5
Q

Depression - presentation, score, screening

A

Depression, screen with PHQ-9: feeling down / hopeless, anhedonia + loss of interest, poor sleep / eating / concentration, psychomotor retardation, thoughts of self harm / suicide
Core symptoms: low mood, anhedonia, anergia (energy). Somatic / biological symptoms: early morning waking, psychomotor, loss of appetite + libido, diurnal mood variation

Have to screen for self harm + suicide: can’t keep going, don’t want to wake up, ending your life, previous attempts. If so: plans, final acts, what stopped you

PHQ-9: > 16 = moderate / severe, indication for SSRI (as well as CBT), mild self guided / CBT. Electroconvulsive therapy can be used in severe - especially in treatment resistant

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6
Q

Anxiety - presentation, scoring, types

A

Anxiety: persistent worry or fear that impacts daily life, several different types of anxiety disorders, assess with generalised anxiety disorder (GAD-7) questionnaire
GAD-7: not at all 0 / several days 1 / more than half 2 / nearly every day 3; feeling as if something bad will happen, easily annoyed, so restless hard to sit still, trouble relaxing, worrying too much, net being able to stop worrying, feeling on edge. 5/10/15 - Mild / M / S

Presentation: excessive worrying, restlessness, unexplained pain, tachycardia, sweating, trembling, fatigue, difficulty concentrating, irritability, sleep disturbance

Types: GAD, panic disorder (frequent attacks), social anxiety, phobias, OCD, PTSD

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7
Q

Schizophrenia - definition, presentation, first rank symptoms

A

Schizophrenia: persistent psychosis, disordered thinking and cognitive impairment. Strongly linked to childhood adversity, commonly presents early 20s in men and ~ 30 in women

Positive: hallucinations, delusions, disorganised thinking (illogical + confused speech), impaired insight
Negative: affective (emotional) flattening, alogia - poverty of speech, anhedonia, lack of motivation, social difficulties and withdrawal

First rank symptoms: special type auditory hallucinations (3rd person, running commentary, thought echo), delusions of thought interference (withdrawal / insertion / control), passivity phenomena (thoughts + actions out of their control), delusional perception

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8
Q

Describe psychosis

A

Psychosis: hallucinations, delusions, disorganised thinking, impaired insight, emotional dysregulation, all lead to functional impairment
Many causes: bipolar, schizoaffective disorder, major depressive disorder, drug induced (withdrawal), postpartum, neurological, PTSD
After first episode of psychosis, looked after by early intervention team for 3 years
Seen as emergency - longer untreated the worse the outcome. Antipsychotics needed 18m following first episode to prevent relapse

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9
Q

Describe schizoaffective disorder

A

Schizoaffective disorder: types bipolar / depressive, mood component more present than not, less decline in function than in schizophrenia
Treatment the same: atypical antipsychotic, SSRI for depressive, lithium / valproate for bipolar, CBT, psychoeducation, family / group

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10
Q

Describe bipolar, different types, management

A

Bipolar: cycling periods of depression and mania lasting minimum days (have to have 2 periods of mania). I: manic episode, often followed by depression / hypomania; 2: major depressive and hypomanic episodes; cyclothymic (milder): mood swings between hypomania and depression

Mania: elevated, irritable, overactive, poor concentration, racing thoughts, pressured speech, grandiose, social / sexual inhibition, poor insight, may have psychotic symptoms
Hypomania: elated, overactive, social disinhibition, overspending, poor sleep, continues to function partial insight, no psychotic. Often feel good and may improve performance. Lasts less long than mania
Also have typical depression periods

Acute: mania: antipsychotic, lithium / sodium valproate if required, taper antidepressants; depression: antipsychotic or fluoxetine with olanzapine or lamotrigine. Quetiapine drug of choice for type 2
Olanzapine has quick onset and good at mood stabilisation, helps sleep
Long term: lithium (valproate, olanzapine if not tolerated)

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11
Q

Describe OCD

A

OCD: intrusive + distressing thoughts (obsessions) and repetitive behaviours (compulsions) to reduce the anxiety caused by the obsessions, temporary belief reinforces the cycle.
Tends to have significant impact on life, often aware the thoughts are irrational, can be as extreme as causing suicide
CBT, exposure and response prevention (ERP) therapy, SSRI (min 12w), severe - clomipramine (TCA)

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12
Q

Describe anorexia, screening, investigations, management

A

Anorexia: SCOFF screening tool (sick because full, control lost, one stone lost in 3m, feel fat when others disagree, food dominates life - 2+). Fear of weight gain, other psychological issues, reluctance to help, distorted image of self. Signs: BMI < 18.5, cardiovascular instability, hypothermia, reduced power (sit up squat stand test), electrolyte imbalance
Eating disorder focused CBT, MANTRA therapy (understanding, goal setting, motivation etc), nutritional counselling
G+Cs raised: growth hormone, glucose, glands (saliva), cortisol, cholesterol, carotenaemia

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13
Q

Describe refeeding syndrome

A

Refeeding syndrome: hypophosphataemia + hypokalaemia + hypomagnesaemia (due to insulin spike, can cause Torsades de pointes), untreated leads to organ failure + arrhythmias. If haven’t eaten for 5 days first 2d only 50% requirements. Also risk in elderly after critical illness / surgery

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14
Q

Describe PTSD and complex PTSD

A

PTSD: single period of trauma (may have several experiences close together), recurrent intrusive thoughts, avoidance, persistent negative mood, hypervigilance
Typically within 3m of event, can last for life. Diagnosed 4w after the trauma, until then acute stress disorder

Intrusive: flashbacks, nightmares, emotional distress. Mood: feelings of detachment, distorted thinking patterns. Hypervigilance: irritability, aggression, heightened startle response, difficulty concentrating

Trauma based CBT / DBT, EMDR. Drugs for persistent: SSRI / venlafaxine, amitriptyline

Complex PTSD: repeated / chronic exposure to traumatic experiences. Shares flashbacks, avoidance, hypervigilance. Also: emotional dysregulation, self identity + relationship issues.
Emotions: mood swings, anger + aggression, sadness. Self: deep sense of worthlessness, shame, guilt. Difficulty forming and maintaining meaningful relationships

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15
Q

Describe postpartum mental health conditions

A

Baby blues seen in 60-70% 3-7d post, change in hormones, reassure and support

Postnatal depression: 1-3m post, presents like normal depression typically with doubts about being a mum; use Edinburgh postnatal depression score (score >13 = depression); CBT + support groups etc; paroxetine (low milk expression) or sertraline in severe

Puerperal psychosis: 2-3w, mood swings like bipolar, disordered perception and delusions; admit to mother and baby unit

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16
Q

Describe functional disorders

A

Functional disorders - no identifiable cause

Somatisation disorder: presence of physical symptoms (for at least 2y) due to a mental health disorder; pain. Fatigue, GI, neuro

Conversion disorder: typically involves CNS, loss of motor / sensory function, patient often indifferent

Hypochondriasis: illness anxiety, persistent belief that there is a serious underlying disease despite negative tests. (Somatisation = symptoms, hypoChondriasis = cancer)

Factitious (Munchausen’s): intentional production of symptoms

17
Q

Describe personality disorders

A

Personality disorders are complex conditions that affect the way they think / perceive / feel / relate to others, often difficult diagnosis for patients. Common features: overwhelmed by negative emotions, empty / emotionally disconnected, difficulty maintaining relationships, odd behaviours
No medications licensed for personality disorders, focus on therapies and bettering themselves. Can treat associated disorders

18
Q

Describe dialectical behavioural therapy

A

Dialectical behaviour therapy designed for use in personality disorders, focus is changed from changing negative thoughts (CBT) to accepting the negative emotions, validating and dealing with them healthily.
Mindfulness, emotional regulation, interpersonal skills, coping strategies, group therapy
Also helpful in OCD, eating disorders, PTSD, substance use, mood

19
Q

Alcohol addiction tools, management, complications + management

A

CAGE screening, AUDIT questionnaire for dependence, SAD-Q severity of dependence.
Long acting benzo for withdrawal symptoms - chlordiazepoxide / diazepam for withdrawals. Preventing relapse: acamprosate (stabilises GABA - reduces craving), naltrexone (blocks endorphins from drinking), disulfiram (makes consumption unpleasant)
Feel shit = benzo. A camp prostate (prevents) relapse (craving). Disulfiram makes consumption dire. Naltrexone opioid antagonist - no good feeling.
Withdrawal: symptoms 6-12h, seizures 36h, delirium tremens 72h
Risk of delirium tremens (agitation, paranoia, hallucinations, seizures) - give lorazepam. Wernicke’s encephalopathy (thiamine deficiency) - ophthalmoplegia, confusion + ataxia. Untreated becomes Korsakoff syndrome - amnesia + cognitive impairment

20
Q

Opioid withdrawal management and overdose presentation

A

Opioid: withdrawal within 8h, peak 36-72h, stop after 5d.
Methadone / buprenorphine used as detox / substitution therapy (naltrexone rapid detox). Overdose: pinpoint pupils, respiratory depression, unconscious; give naloxone (short half life may need second dose)

21
Q

Describe management of paracetamol overdose

A

Paracetamol overdose: plasma concentration and timing plotted on normogram - treatment line; presenting within 1h can give activated charcoal (large surface area, absorbs doesn’t go in blood); N-acetylcysteine main treatment - infuse over 1h, provides glutathione enzyme (depleted in overdose) to help metabolise the toxic metabolite NAPQI
Liver transplant: ph <7.3 after 24h, prothrombin >100s, creatinine >300, grade III/IV encephalopathy

22
Q

Describe CBT

A

CBT: thoughts / emotions / behaviour are interconnected (negative thoughts lead to negative behaviour), aim to address negative thoughts (replace with more rational / positive) to stop negative behaviour patterns. Goal setting and strategies for behaviour. Broad use

23
Q

Describe EMDR, E+R therapy, electroconvulsive therapy

A

Eye movement desensitisation and reprocessing therapy: recalling traumatic events whilst doing specific eye movements, change the emotional response

Exposure and response therapy (OCD, PTSD, phobias), psychodynamic (childhood experiences, depression / anxiety / BPD), family / couples therapy (eating disorders, substance misuse etc), interpersonal (depression)

Electroconvulsive therapy - severe depression, mania, catatonia: short acting anaesthetic + muscle relaxant, induced seizures, typically takes up to 12 courses
Good at treating treatment resistant depression but tend to relapse after 6m
Can cause short term memory loss + confusion, risk of arrhythmias
Reduce but don’t stop SSRIs, increase at end of treatment

24
Q

Why are atypical antipsychotics used

A

Atypical antipsychotics (wider range of receptors in brain): usually used when higher dose required; better at treating negative symptoms, lower risk of EPSEs, less cognitive impairment, more sedation + metabolic symptoms, some increase prolactin. Typical (D2 receptor): cheaper + more studies, more ESPEs, risk of neuroleptic malignant syndrome, cognitive impairment. Patient decides on SEs

25
Q

Describe the antipsychotics side effects

A

Antipsychotic main side effects: olanzapine - dyslipidaemia + weight gain + sedation (can be helpful), quetiapine - postural hypotension + hyperprolactinaemia (sedative - can be useful), risperidone worst for hyperprolactinaemia. Aripiprazole lowest SE profile, only a partial dopamine agonist + lowers prolactin

Clozapine - treatment resistant only (trialled 2): reduced seizure threshold, constipation, myocarditis, agranulocytosis (neutrophils, eosin + baso). Due to complications patients registered to supplier and they are in charge of monitoring, baseline ECG and regular FBC
Annual monitoring with GP: ECG, full blood count, HbA1c + lipids, prolactin, weight, MSE

26
Q

Describe antidepressants, first + second line, duration, interactions

A

SSRIs: sertraline / fluoxetine (FL - adolescents) / citalopram first line, (safest). Citalopram risk of long QT, adverse: palpitations, GI, insomnia, anxiety, sexual dysfunction, NSAID reaction. At first can make symptoms worse and in adolescents increased suicidality at first

Second line: different SSRI / venlafaxine (SNRI) / mirtazapine (xNASSA). Mirtazapine has few SE and interactions, good for use in elderly + eating disorders (increases appetite)

Single episode: 6-9m of treatment after resolution of symptoms, recurrent at least 2y

Anxiety: sertraline FL, SL - another SSRI / duloxetine / venlafaxine

Can’t take with other drugs that increase serotonin (triptans, MAOIs), increase risk of GI bleeding - careful with NSAIDs (PPI) + warfarin / heparin (mirtazapine), can cause hyponatraemia

27
Q

Describe mood stabilisers

A

Lithium: mood stabiliser in bipolar, narrow therapeutic window of 0.4-1, monitor renal + thyroid
Important to measure levels 12 hours after dose every 3m. Causes benign increase in WCC, impaired renal function (U+Es), hypothyroidism (TFTs), QT syndrome (ECG)
Toxicity: confusion, hand tremor (fine → coarse with time), weakness + twitching, seizures, long term use can result in hyperparathyroidism (hypercalcaemia)

Other mood stabilisers: lamotrigine (safest, depression not mania), carbamazepine + valproate

Lithium and lamotrigine safest in women of child bearing age, C+V tetarogenic

28
Q

Describe serotonin syndrome and neuroleptic malignant syndrome

A

Serotonin syndrome: single high dose of medication or drug interaction, rapid onset
Neuromuscular excitation: tremor, hyperreflexia, clonus, rigidity. Autonomic excitation: tachycardia, hypertension, hyperthermia, diaphoresis. Altered mental status
Complications: heat stroke (high body temp), cardiac arrest, seizures, organ failure
Discontinue meds, IV fluids, sedation with benzodiazepines, if required cyproheptadine can block serotonin production

Neuroleptic malignant syndrome: typical antipsychotic side effect, can be life threatening
High fever, severe rigidity, agitated delirium, autonomic dysfunction (hypertension, tachycardia + tachypnoea). Bloods: raised creatinine kinase and leukocytosis
Complications: severe dehydration, coma, raised creatine kinase (definite, can lead to rhabdomyolysis), kidney failure, multi organ dysfunction, leukocytosis
Bloods will show raised CK, raised white cells
Cessation of meds, IV fluids (renal failure), bromocriptine (dopamine agonist) / dantrolene (muscle relaxant), dialysis if required following rhabdomyolysis
NMS vs SS: onset, reflexes, rigidity (parkinson’s - dopamine) / clonus, pupils (serotonin - large)

NMS: reduced reflexes, lead pipe rigidity, slower onset; SS: increased reflexes + clonus, dilated pupils, faster onset

29
Q

Describe EPSEs

A

parkinsonism (rigidity, tremors, bradykinesia), akathisia (restlessness) - propranolol. Acute dystonia: sustained muscle contraction, torticollis (stiff neck) common, give procyclidine / benztropine. Tardive dyskinesia: involuntary twitching, usually around face - chewing, tongue; tetrabenazine

30
Q

Describe tyramine induced hypertensive crisis

A

Severe headaches, palpitations, chest pain, sweating, nausea, vomiting + confusion. Severe: SOB, visual disturbances, seizures, stroke
Individuals taking MAOIs (inhibits breakdown) should avoid tyramine rich foods - cheese, yeast, pickled food, smoked meat, red wine + alcohol, soy
Phentolamine / tolazoline as well as a benzodiazepine. Monitor end organ dysfunction