Psychiatry Flashcards
Define Psychosis
Acute condition where people lose contact with reality which usually includes hallucinations and delusions
Give 3 examples of pscyhoses
- Affective psychoses –> depression, bipolar
- Transient psychotic disorders –> substance misuse or withdrawal
- Due to medical disorder –> brain tumour, PD, HD, HIV/AIDS, syphilis, encephalitis
- Schizophrenia life non affective disorders –> brief psychotic disordered, delusional disorder
Give 2 positive symptoms of psychosis
- Hallucinations
- Delusions
- Thought disorder
Give 3 negative symptoms fo psychosis
- Flattened affect
- Cognitive difficulties
- Poor motivation
- Social withdrawal
- Poverty of speech
Define schizophrenia
A severe mental disorder, characterises by profound disruptions in thinking, affecting language, perception and sense of self
A type of psychosis
Briefly describe the pathophysiology of schizophrenia
Neurochemical abnormalities = excessive dopamine production
- Overactivity of neurones = mesolimibic –> hallucination/disorders (+ve Sx)
- Underactivity of neurones = mesocortical –> blunted, anhedonia, apathy (-ve Sx)
When is the onset of schizophrenia most typical?
2nd or 3rd decade
- Mostly men in adolescence
- Mostly omen in middle age
Name 3 subtypes of schizophrenia and briefly describe each
- Paranoid = most common –> paranoid delusions and auditory hallucinations
- Hebephrenic = adolescents/young adults –> mood changes, unpredictable behaviours, shallow affect, fragmentary hallucinations, outlook poor as -ve Sx rapid
- Simple = similar to hebephrenic but characterises by -ve Sx NEVER +ve Sx
- Catatonic = psychomotor features (posturing, rigidity, stupor)
- Undifferentiated = mixed Sx
- Residual = -ve Sx when +ve Sx have ‘burnt out’
What are the first rank symptoms of schizophrenia?
- Delusional perception
- 3rd person auditory hallucinations
- Thought disorder/alienation –> insertion, blocking, echo, withdrawal
- Passivity phenomena = being controlled by external energy/force
What are the second rank symptoms of schizophrenia?
- Delusions
- 2nd person auditory hallucinations
- Catatonic behaviour
- Negative symptoms
How is schizophrenia diagnosed?
ICD 10
At least 1 first rank symptom and 2 2nd rank symptoms present for over 1 month AND no other cause for psychosis (RULE OUT)
What is the non pharmacological management of schizophrenia ?
CBT
Working with families
Addressing housing, social care etc
What is the pharmacological treatment for Schizophrenia?
- 1st Line = Oral atypical (2nd gen) antipsychotics = 5HT2A and D2 agonists –> Aripiprazole, olanzapine, quetiapine, risperidone
- 2nd line = Oral typical (1st get) antipsychotics = dopamine agonists –> haloperidol, chlorpromazine
- 3rd line = Clozapine (atypical antipsychotic)
What is the main side effect of olanzipine?
Weight gain –> 13.9kg in 1 year
What is a potential side effect of clozapine
Agranulocytosis –> FBC monitored regularly (neutrophil levels)
Give 3 possible side effects of antipsychotics
- QTc prolongation –> ECG
- DM/insulin resistance
- Anticholinergic SE = urinary mention, blurred vision, weight gina, hyper salivation, constipation
Give 4 extrapyramdial side effects of antipsychotics
- Acute dystonia = involuntary repetitive movements, neck, blinking, jaw –> treat with procyclidine
- Parkinsonism
- Akathisia = restlessness –> treat with propranolol and BDZs
- Tardive dyskinesia = slow movements, lip-smacking, sudden, involuntary, irreversible
EPSE more common in TYPICAL antipsychotics
What is schizoaffective disorder?
Patients experience both schizophrenia and a mood disorder (affective) at the same time (within days) with the same intensity without a medical disorder or substance misuse cause
What is Neuroleptic malignant Syndrome?
Life threatening reaction in response to neuroleptic or antipsychotic (haloperidol, chlorpromazine) medications
Give 3 clinical features of neuroleptic malignant syndrome
- Slower onset (Days to weeks)
- Fever
- Autonomic instability
- Muscle rigidity = lead pipe
- Tremor
- Seizures, coma
What would you see on investigations in someone with neuroleptic malignant syndrome?
- Raised CK
- Leucocytosis
- Metabolic acidosis
- Prolonged QT
What is the management of neuroleptic malignant syndrome?
- IV hydration
- Benzodiazepines (diazepam)
- Bromocriptine = dopamine agonist
- Dantrolene = muscle relaxants
What are affective disorders?
Illnesses which affect the way you feel and think
Most common = depression, bipolar
What are the 3 core symptoms of depression?
- Low mood
- Anhedonia = loss of enjoyment
- Anergia = low energy