Psychiatric Emergencies Flashcards
Approach to Belligerent Pt
- Utox
- Chem 10
- CBC
- VS
- PE
- patient and personal SAFETY
Approach w/ Intoxicated Pt
expect withdrawal
- discharge from ED
- CIWA- alcohol withdrawal assessment
- consider infectious process
cannot perform psych eval if intoxicated
Approach w/ Cocaine Pt
- check EKG to ensure no MI
- Tx (depends on agitation/paranoia)
- no tx
- benzos
- antipsychotics
Behavioral Predictors of Violence
- angry words
- loud language
- abuse language
- physical agitation (fist, pacing, akasthisia- restlessness)
Assessing Risk of Violence
- history of violence
- circumstances of violence
- substance dependence/abuse (30x)
- antisocial/borderline personality disorder (100x)
- mental illness (9x)
How to De-escalate
- calm voice
- sit down w/ patient
- maintain 6ft distance
- establish rapport
- listen to pt concerns for 1st 5 minutes
- pharmacologic or physical restraints if needed
- Lorazepam 1-2mg IM/IV (PO q4-6h)
- NOT w/ alcohol (additive effect)
- 5% can have increased agitation
Antipsychotic Dopaminergic Pathways
(for agitation suppression)
- Nigro-Striatal
- substantial nigra to basal ganglia
- movement (tardive dyskinesia, akathisia)
- Meso-Limbic
- VTA to nucleus accumbens
- reward pathway (+sx of schizophrenia)
- Meso-Cortical
- VTA to cortex
- motivation/emotional response (-sx of schizophrenia- more debilitating, diff 2 tx)
- Tubulo-Infundibular
- hypothalamus to posterior pituitary
- hypoprolactinemia in untreated but D2 blockade can cause hyperprolactenemia)
Typical Antipsychotics
Strong D2 antagonism in meso-limbic and meso-cortical pathways
- significant extrapyramidal sx (EPS)
- strong CYP-450 metabolism (lots of drug interactions and grapefruit)
- high-potency: minimally sedating, more weight gain, higher EPS risk
low-potency: quite sedating, more anticholinergic (bradycardia, GI upset), lower risk EPS
Atypical Antipsychotics
Bind D2 receptors but higher affinity for serotonin (5HT) receptors
- less risk EPS
- higher risk metabolic side-effects and weight gain
- Cloozapine slightly different
- shorter half-life (less EPS)
- serious risk of agranulocytisis (NOT a PRN/ED med!)
- difficult to restart- keep pt on titrated level
IM Antipsychotics
- Ziprasidone (Geodon) 20mg IM q4h or 10mg q2h not to exceed (NTE) 40mg/24h
- Haloperidol (Haldol) 1-5mg IM q1h NTE 20-30mg/24h
- Olanzapine (Zyprexa) 5-10mg IM NTE 20mg/24h (risk of hypotension in elderly)
- Droperidol (Inapsine) 2.5-5mg IM/IV - BLACK BOX for arrhythmias
PO Antipsychotics
- Risperidone (Risperdal) 1-2mg PO NTE 6mg/24h (Risperdal M-tab rapid melting tab)
- Olanzapine 10-20mg PO NTE 20mg/24h (Zydis rapid melting tab)
- Haloperidol 1-5mg PO q1-2h NTE 30mg/24h
*can ask pt if they’ve had prev success w/ drug
Extrapyramidal Symptoms
muscle tightness in limbs, tongue/neck tightness, sense of choking more rare
- Haldol most likely, then Risperidone
- Atypical have less risk
- MC in young male AA and older women
EPS Treatment
- O2 if breathing problems
- Diphenhydramine (Benadryl) 50mg PO/IM/IV q4-5h
- Benztropine (Cogentin) 1-2mg PO/IM q8-12h
Serotonin Syndrome
(MANY SSRIs)
-
mental changes
- anxiety, confusion, restlessness, agitation, decreased LOC
-
neuromuscular abnormalities
- tremor, hyperreflexia, clonus, rigidity, wrist or ocular myoclonus, ataxia
-
autonomic hyperactivity
- diaphoresis, hyperthermia, shivering, mydriasis, nausea, diarrhea
- VS: tachycardia, labile BP changes
- S/s seen on a spectrum
Seratonin Syndrome Tx
- d/c all serotonin agents
- supportive care (often no tx required)
- consult medical toxicologist, clinical pharmacologist, or poison control
- Cyproheptadine (serotonin antagonist)
- intubation and ventilation if severe w/ hyperthermia (>41.1 C)