Psychiatric emergencies

Question 1

Serotonin syndrome triad of

Answer 1

neuromuscular abnormalities (myoclonus, and clonus), altered mental state, and autonomic dysfunction

Question 2

Serotonin syndrome treatment

Answer 2

withdrawing the cause
supportive care
control of agitation

administration of a 5HT-2A antagonist such as cyproheptadine

Question 3

Serotonin syndrome cause

Answer 3

iatrogenic from synergistic medication
addition of drugs that inhibit the cytochrome P450 2D6 and/or 3A4 (CYP3A4) isoenzymes

Question 4

Drugs contributing to serotonin syndrome
Amphetamines and derivatives

Answer 4

3,4-methylenedioxymethamphetamine (Ecstasy)
Dextroamphetamine
Methamphetamine
Sibutramine (Meridia)

Question 5

Drugs contributing to serotonin syndrome Analgesic

Answer 5

Cyclobenzaprine (Flexeril)
Fentanyl (Duragesic)
Meperidine (Demerol)
Tramadol (Ultram)

Question 6

Drugs contributing to serotonin syndrome Antiemetics

Answer 6

Metoclopramide (Reglan)
Ondansetron (Zofran)

Question 7

Drugs contributing to serotonin syndrome Antimigraine drugs:

Answer 7

Carbamazepine (Tegretol)
Ergot alkaloids
Triptans
Valproic acid (Depakene)

Question 8

an antiepileptic drug, has been particularly associated with the development of Stevens-Johnson syndrome (SJS)

Answer 8

Lamotrigine