Psychiatric disorders Flashcards
Psychotic disorders Mood disorders Neurotic disorders Personality disorders Eating disorders
What does psychosis mean and what are the symptoms?
A person is experiencing a reality that is different to everyone else, they usually lack insight
- Hallucinations - perception without an external stimulus. Auditory most common in psychosis and means they hear something that isn’t there (cf visual in delirium), olfactory may indicate frontal lobe issue
- Delusions: a fixed firmly-held belief out of keeping with their social/cultural norms. E.g. persecutory, grandiose, reference, hypochondriacal
- Formal thought disorder: problem with speech where each sentence/word/phrase doesn’t link from the next (cf flight of ideas where there are some connections)
- Thought broadcast, passivity phenomenon, thought insertion
What is a pseudohallucination?
‘Hearing voices inside head’ not a hallucination; auditory hallucination is where they think it’s coming from outside (but isn’t actually there)
What causes schizophrenia (a chronic relapsing condition)?
- Bio: overactivity of dopamine pathways - so antipyschotics block D2 receptors. Reduced serotonin + GABA + glutamate. May be a/w neurodevelopmental issues
- Genetic: FH
- Environmental: adverse life events, smoking cannabis, psychostimulants
What are the types of schizophrenia?
- Paranoid: commonest, prominent hallucinations+/-delusions
- Hebephrenic: thought disorganisation main thing, fleeting delusions/hallucinations
- Catatonic: rare. Stupor, negatvisim
- Simple: negative sx, no psychotic
What are the features of schizophrenia?
POSITIVE:
- Thought interference: insertion (have you experienced thoughts that aren’t yours and have been put there by someone else?), broadcast (people overhear thoughts), withdrawal (are thoughts being taken out of your mind?)
- Delusions: persecutory (someone trying to harm you), grandiose (special powers/abilities), reference (people doing/saying things that have special meaning to you)
- Hallucinations: usually 3rd person auditory (talking about you, vs 2nd person talking to you), running commentary (make comments on what you’re doing)
- Persistent delusions/hallucinations
- Passivity phenomenon - feeling under control of an outside force
- Formal thought disorder - incoherent/irrelevant speech that changes direction/goes off at tangents/odd words/loosening of associations
- Catatonic behaviour: purposeless behaviour e.g. posturing, negativism, mutism
NEGATIVE (all begin with A)
- Avolition
- Asocial behaviour
- Anhedonia
- Alogia (poverty of speech)
- Affect blunted
- Attention deficits
What are Schneider’s 1st rank sx of schizophrenia?
- delusional perception
- 3rd person auditory hallucinations
- hearing thoughts spoken aloud, thought broadcast
- thought interference
- passivity phenomenon
- physical hallucinations
How is schizophrenia managed?
BIO
- Investigate for organic causes
- ECG as antipsychotics can cause long QTc
- Antipsychotics: D2 antagonists. Usually try second generation first (so amisulpiride, olanzapine etc) then if resistant after 2 try clozapine
- BZDs for short-term relief of behavioural changes
- Antidepressants and/or lithium may be used
- ECT when resistant to drug therapy, good for catatonic
PSYCHO
- Psychosis early intervention teams for 1st presentation
- CBT
- Help with negative sx
SOCIAL
- CPN
- SW, living arrangements
- Family/carer support
Give some organic causes of psychosis
Drugs - alcohol, cocaine, amphetamine, MDMA, mephredrone, cannabis, LSD, ketamine
Iatrogenic - levodopa, metyldopa, steroids, antimalarials
What are other psychotic disorders?
- Schizoaffective disorder: sx of mood disorder + schizophrenia at the same time (so criteria for mania/depression plus couple of schizophrenic sx)
- Schizotypal PD: partial expression of schizophrenia with eccentricity, unusual speech, deviations of thought but without hallucinations/delusions
- Schizophreniform disorder: some sx of schizophrenia + reduced functioning but doesn’t meet diagnostic threshold
- Acute transient psychosis: lasting <1m
- Mood disorders with secondary psychosis
- Puerperal psychosis: acute mania/psychosis soon after birth (usually within 2w)
- Persistent delusional disorder: single/multiple delusions for at least 3m, without other prominent sx and function + think normally apart from this. Often related to life situation
- Induced delusional disorder (Folie a deux): uncommon, similar delusions in 2 or more people
What is bipolar affective disorder?
Chronic, episodic mood disorder with at least 1 episode of mania/hypomania + another episode of mania/depression
RF: anxiety/depression, FH, substance misuse, adverselife events
Bipolar 1 - severe mood episodes
Bipolar 2 - milder form of hypomania and severe depression
Rapid cycling bipolar - >4 mood swings in 12m with no asymptomatic periods
What are the features of BPAD?
- Mania:irritability, distractibility, disinhibted (sexual, social, spending), impaired insight, increased libido, grandiose ideas, flight of ideas/pressure of speech, high activity/energy, reduced sleep/concentration. Lasts 1w+
- Mania + psychosis: severely elevated/suspicious mood, psychotic features, grandiose delusions, auditory hallucinations (mood-congruent)
- Hypomania: mildly elevated/irritable mood, sx of mania but to a lesser extent, interferes with work/social life, may have partial insight. Lasts 4d+
- Depression (at least 2w): depressed mood, anhedonia (at least 1 of these). May also have sleep increase/insomnia, WL/WG, psychomotor retardation/agitation, low energy, feeling of worthlessness/guilt, reduced concentration, preoccupation with death/suicide
What are the possible MSE findings in bipolar disorder (manic episode)?
Appearnace: flamboyant/unusual clothing, personal neglect
Behaviour: overfamiliar, disinhibited, psychomotor agitation, distractible, restless
Speech: loud, fast, PoS, puns + rhymes, neologisms
*Mood: elated, euphoric, irritable
*Thought: optimistic, pressured thought, FoI, LoA, circumstantiality, tangenitality, overvalued ideas, grandiose/persecutory delusions
*Perception: mood-congruent auditory hallucinations (may happen)
*Cognition: orientated, attention impaired
*Insight usually v poor
What investigations are useful for BPAD?
- TFTs: high/low are a differential
- U+E: baseline renal function for lithium
- LFT: same reason
- Glucose, calcium - disturbance can cause mood sx
- Urine drug tests - can cause manic sx
- CT head - space occupying lesions
How is BPAD managed?
BIO
- Atypical antipsychotic- acute episodes of mania, consider long-term with olanzapine/quetiapine
- Mood stabiliser - lithium in mania (if acute episode check levels to optimise, is also 1st line to prevent relapses), in bipolar depression can use lamotrigine, sodium valproate (not in women child bearing age)
- BZD or rapid tranquilisation sometimes
- Antidepressants usually avoided alone as can induce mania; may use fluoxetine + lithium
- ECT can be used in refractory cases
- Monitor lithium levels, weight, U+E, TFT
PSYCH
- Risk assessment, may need MHAA
- High intensity CBT for bipolar depression
- Discuss how to recognise relapses
SOCIAL
- Driving guidelines from DVLA
- Financial support
What factors contribute to the development of depression?
BIO
- female, postnatal, genetics, neurochemical (low serotonin, noradrenaline, dopamine), endocrine (HPA overactivity), physical co-morbidities, PMH depression
- poor compliance with meds, corticosteroid use
- chronic health issues
PSYCH
- personality type, poor coping strategies, MH comorbidities e.g. dementia
- acute stressful life events
- poor insight, negative thoughts about self/world/future
SOCIAL
- stressful life events, lack of social support
- unemployment, poverty, divorce
- alcohol/drugs, poor social support, reduced social status
What are the symptoms of depression?
- Core sx: anhedonia, low mood for at least 2w (little variation + unresponsive to circs), lack of energy
- Cognitive sx: low self-esteem, excessive guilt/feelings of worthlessness, negative thoughts about self/world/future, lack of concentration nearly daily, suicidal/self harm ideation, hypochondriacal thoughts, hopelessness
- Biological sx: diurnal mood variation (esp morning worse), early morning wakening, hypersomnia, loss of libido, psychomotor retardation, weight loss (may also gain)
- Psychotic sx: 2nd person auditory hallucinations, hypochondriacal/guilt/nihilistic/persecutory delusions
What organic problems may cause depression-like sx?
- anaemia
- hypothyroidism
- biochemical - U+E, LFT, calcium, vit D, B12
- anergia from DM
- intracranial lesion
- rare things like Addison’s, Cushing’s
- parkinsonism
How is depression managed?
BIO
- rule out organic problems
- Antidepressants: usually if moderate-severe depression, or moderate recurrent. For first episode continue for 6-12m, for subsequent episodes continue at least 6m after relapse. Usually generic SSRI first, then may use an SNRI, don’t really use TCA/MAOI anymore. May be augmented with lithium or antipsychotics
- Manage co-morbidities
- ECT - if severe refractory, or things like catatonia
PSYCH
- risk assessment
- MHAA may be needed
- mild-mod: low intensity/group CBT
- high intensity psychological intervention - IAPT referral
SOCIAL