Psychiatric/Behavioral & Substance Abuse Flashcards
When could you suspect Lamotrigine as the cause of a seizure?
If the patient has seizure hx and stops taking their medication
- Insert any anticonvulsant into this catagory
What is considered a normal response to stress?
Not excessive or out of proportion
No significant functional impairment
- Social and occupational
- Key diagnostic criteria
Everyday occurrences have a special implication
- TVs or radio speaking directly to them
- Articles have special messages
Ideas of reference
Common with schizophrenia
What is the DOC for acute treament of panic disorder?
Benzos
Benzodiazepine used most often to induce conscious sedation during medical procedures
Midazolam
- No role in treating anxiety disorders
Irritable, drowsy, fatigued, and hungry
Psychomotor agitation or retardation may also present
Cocaine withdrawal
Amphetamine withdrawal- May also have depression
Onset 12 to 48 hrs after last dose
Sweating, hyperreflexia, tremors, and seizures
Acute hallucinosis without autonomic symtpoms
Altered sensorium, hallucinations, and autonamic instability
Death
Alcohol withdrawal
Benzodiazepine withdrawal
Irritability, anxiety, depression, insomina, restlessness, poor concentration, increased appetite, weight gain, and bradycardia
Nicotine withdrawal
When should you suspect Alpazolam instead of bupropion in a patient experiencing seizures?
When the patient abruptly stops the medication
i.e. withdrawal type picture
Behaving as if an aspect of reality does not exist
Denial
Transferring feelings to a more acceptable object
Displacement
Alterin perception of upsetting reality to be more acceptabe
Distortion
Separating a thought from its emotional components
Isolation of affect
Attributing one’s own feelings to others
projection
Responding in a manner opposite to one’s actual feelings
Reaction formation
Channeling impulses into socially acceptable behavior
Sublimation
Putting unwanted feelings aside to cope with reality
Suppression
Mature defense mechanisms
Altruism
Humor
Sublimation
Suppresion
What would a prolactin level be if the cause of the hyperprolactinema was a prolactinoma and not an antipsychotic?
> 200 ng/mL
Patient has fever, rigidity, mental status changes, and autonomic instability. They have a history of antipsychotic use. What is the condition?
Neuroleptic malignant syndrome
What types of medications cause neuroleptic malignant syndrome?
Medications that block dopamine transmission
- Most common with high-potency antipsychotics
What is the appropriate way to manage a patient with neuroleptic malignant syndrome?
- Stop the medication
- Monitor in ICU
- Control temperature
- Watch electrolytes
- Dantrolene- if severe
What are the risk factors for suicide?
SAD PERSONS
Sex- Male
Age- Young and Old
Depression
Previous attempt EtOH Rational thought loss (Psychosis) Social support- Lack of Organized plan No spouse or significant other Sickness or injury
Which suicidal patients are considered high-risk and should be admitted?
Those with intent and a plan
- Admit
- Remove items that can be used for harm
- Constant observation
How do you manage suicidal patients who are high-risk, but have no plan to act in the near future?
- Treat modifiable risk factors
- Recruit social support
- Reduce access to means
Which serotonin receptor is antagonized by atypical antipsychotics to help allevaite negative symptoms and decrease risk of EPS?
5-HT2A
What receptors does risperidone bind to?
Alpha-1 - No theraputic effect
Dopa-2 - Antipschotic
5-HT2A - Treats negative symptoms and decreases risk of EPS
What are the 4 broad categories of conduct disorder?
- Aggression toward people and animals
- Destruction of property
- Serious violation of rules
- Deceitfulness or theft
How many symptoms must be present in conduct disorder? How many months?
- 3+
- Last 12
*At least 1 must have been present in the last month
What are indications for ECT?
Severe depression Depression in pregnancy Refractory mania NMS Catatonic schizophrenia
What are the side effects of ECT?
Amnesia Prolonged seizures Delirium Headache Nausea Skin burns
What is the BMI critera for anorexia nervosa?
What is the recommended treatment for anorexia?
CBT
Nutritional rehab
Olanzapine- if unresponsive
What is the recommended treatment for bulimia?
CBT
Nurtitional rehab
SSRI- Given as adjunct
What are is the recommneded treatment for binge eating disorder?
CBT
Behavioral weight loss therapy
SSRI
Lisdexamfetamine, topiramate
What are the risk factors for homicide?
Young male Unemployed Impoverished Access for firearms Substance abuse Antisocial personality disorder History of violence History of childhood absue Impulsive
What lab value is elevated during NMS?
CPK- Rhabdomyolysis
What is a common complication of NMS?
Acute kidney failure- Rhabdomyolysis -> Myoglobinuria
What are the basic critera for pathologic gambling?
Persisten and maladaptive gambling behavior
Often dishoneset and evasice when confronted
What are the FDA approved first-line treatments for OCD?
CBT is also recommended
Clomipramine Fluoxetine Fluvoxamine Paroxetine Sertraline
SSRI first, then another SSRI or Clomipramine
Increased risk of jaundice
Chlopromazine
Pigmentary retinopaty
Thioridazine
Cataracts
Quetiapine
What is a major mental health risk for someone who has been sexually assaulted?
Suicidal ideation and attempts
Physical aggression, severe agitation, impulsivity, impaired judgement, psychosis, paranoia, or hallucinations.
Ataxia, nystagmus, & muscle rigidity
Phencyclidine (PCP)- Intoxication
What other intoxication presents with ataxia, nystagmus, aggression, and impaired judgement?
EtOH
Pinpoint pupils, drowsiness, CNS deprssion, and constipation
Heroin intoxication
- Opiods
Mood impairment, hallucinations, subjective perceptual intesification, depersonalization, and illusions
2+
Sweating, tachycardia, pupillary dialation, palpitations, tremors, and poor concentration
Lysergic acid (LSD) intoxication
Anxiety, aggression, psychosis, formication, or delirum
High BP, tachycardia or bradycardia, sweating, pupillary dilation, nausea or vomiting, or insomnia
Nose bleed or septal perforation
Cocaine intoxication
What is the effect of ODing on cocaine?
Think heart and brain
Cardiac arrhythmias
MIs
Seizures
Stroke
Which drug is most commonly associated with agitation and aggresion?
PCP
Tongue protrusion and twisting Lip smaking, puting, and puckering Retraction of the cornters of the mouth Chewing movements Limb twisting and spreading Piano-playing finger movements Foot tapping Dystonic extension of the toes Torticollis Shoulder shrugging Rocking or swaying Rotary hip movements Grunting noies
Signs and symptoms of tardive dyskinesia
What is the most likely atypical antipsychotic to cause TD? Lest likely?
Risperdone
Clozapine
Subjective feeling of restlessness that compels to not sit still and cosntantly move around
Akathisia
- Treat with beta-blocker
Muslce spasms or stiffness, tongue protrusion or twisting, opisthotonus, and oculogyric crisis
Dystonias
- Treat with antihistamines or anticholinergics
4 hrs to 4 days after medication
Cogwheel rigidity, masked facies, bradykinesis, pill-rolling finger tremors, and shuffling gait
Parkinsonism
- Treat with anticholinergics (Benzotropine)
What is the time requirement for delusional disorder?
1+ month
What is a major key difference between delusion disorder and other psychosis?
Ability to function is minimally impaired
What is the chance of a person developing bipolar disorder in their lifetime if they have a first degree realtive with bipolar disorder?
5-10%
- 60% if both parents suffer from it
- 70% if a monozygotic twin has it
Mania/Hypomania is characterized by elevated/irritable mood and increased energy. What other symptoms are needed? How many are needed?
DIG FAST
Distractability
Impulsivity- High-risk behavior
Grandiosity
Flight of ideas or racing thoughts
Activity- Increased goal directed activity
Sleep- Decreased
Talkativeness- Increased
3 with elevated mood; 4 if only irritable
How does hypomania differ from mania?
Symptoms last 4+ days (instead of 1+ week)
No marked impairment
No psychosis
Bipolar I vs Bipolar II
Bipolar 1
- Mania
- Does not need depression
Bipolar 2
- Hypomania
- 1+ Episode of major deprssion
Cyclothymia critera
2+ years
Fluctuating hypomania and depressive symptoms
Does not meet critera for hypomania or major depression
How many SiG E CAPS symptoms are required for MDD?
4+
Also depressed mood or anhedonia
What is the most effective strategy to address MDD? What if the patient has a short life expectancy?
SSRI
Psychostimulant- Methylphenidate or Modafinil
*Supportive thearpy is good, but does not shorten MDD episodes
What is the appropriate approach to treating a patient with hypochondriasis?
- Evaluate for psychological stressors
2. Follow-up with psychotherapy
How many symptoms from PANICS need to be present to make a panic disorder dx?
4+
What is the most effective treatment for panic disorder?
Immediate: Benzos
Long-term: SSRI or SNRI or CBT
What are common comorbidities of panic disorder?
MDD: 60%
Bioplar disorder
Agoraphobia: 40%
Substance abuse
What is the recommneded duration of lithium treatment based on number of manic episodes?
1 episode: 1 year from time of remission
2 episodes: years to lifetime
3 episodes: Lifetime
Indications for clozapine
Treatment-resistant schizophrenia
Schizophrenia associated with suicidality
Adverse effects of clozapine
Agranulocytosis
Seizures
Myocarditis
Metabolic syndrome
What is the time requirement to dx social anxiety disorder?
> 6 months
When should perforamnce-only anxiety be made?
Public speaking or presentations and performers
What is the treatment for performance-only anxiety?
Benzo or beta blocker 30 to 60 min prior to situation
CBT
What is the treatment for GAD and Social?
SSRI or SNRI
CBT
Violent behavior Dissociation Hallucination Amnesia Nystagmus- CLUE CLUE CLUE Ataxia
PCP intoxication
Visual hallucinations- CLUE CLUE CLUE
Euphoria
Dysphoric/panic
Tachycardia/Hypertension
LSD intoxication
Euphoria Agitation Chest pain- CLUE CLUE CLUE Seizures- CLUE CLUE CLUE Tachycardia/Hypertension Mydriasis
Cocaine intoxication
Violent behavior, psychosis Diaphoresis Tachycardia/Hypertension Choreiform movements Tooth decay
Methamphetamine intoxication
Increased appetite- CLUE CLUE CLUE Euphoria Dysphoria/panic Impaired time perception- CLUE CLUE CLUE Dry mouth Conjunctivale injection- CLUE CLUE CLUE
Marijuana intoxication
Euphoria Depressed mental status- CLUE CLUE CLUE Miosis- CLUE CLUE CLUE Respiratory distress- CLUE CLUE CLUE Constipation
Heroin intoxication
Highest risk second generation antipsychotics?
Olanzapine
Clozapine
Lowest risk second generation antipsychotics?
Aripiprazole
Ziprasidone
Monitoring guidelines for second generation antipsychotics?
BMI: Baseline the monthly
Metabolic profile, waist, & blood pressure: Baseline, 3 months, then annually
Antagnosit of what receptor causes EPS?
D2
Antipsychotics
(Typicals, quetiapine, and clozapine)
Treatment for acute dystonic reactions?
Benzotropine or diphenhydramine
Treatment for akathisia?
Benzos (Lorazepam)
EPS that have no known treatment?
Parkinsonism
Tardive dyskinesia
What kind of behavior accompanies body dysmorphic disorder?
Repetitive behavior or mental acts
- Response to preoccupation
What is the treatment approach for a patient with body dysmorphic disorder?
- Establish theraputic alliance
- Explore thoughts and educate patient about options
- Psychotherapy
- SSRI
Alcohol withdrawal syndrome:
6 to 24 hrs
12 to 48 hrs
48 to 96 hrs
6 to 24 hrs: Mild withdrawal
12 to 48 hrs: Seizures & Alcholic hallucinosis
48 to 96 hrs: DTs
Anxiety Insomnia Tremors Diaphoresis Palpitations GI distress Intact orientation
Mild EtOH withdrawal
Visual, auditory, or tactile hallucinations
Intact orientation
Stable vital signs
Alcohol hallucinosis
Confusion Agitation Fever Tachycardia/HTN Diaphoresis
DTs
Peak of alcohol withdrawal?
Day 2
What is the treatment for EtOH withdrawal?
Benzos
- Lorazepam: DOC if liver disease is present (no active mets.)
- Diazepam
- Chlordiazepoxide
Aside from the time critera, what is another difference between schizophreniform and schizophrenia?
Do not need functional decline
What is the treatment appraoch to depression in a cancer patient?
- Pain control
- Psychotherapy and SSRI: Low threshold for SSRI therapy
- SUPPORT groups will not decrease duration of depressive episode.
What is the appropriate approach to a patient with hypochondriasis?
Hypochondriasis is worse during times of emotional stress, inquire about emotional stressors.
What are the major comorbidities associated with panic disorder?
Major depression
- Higher risk of SI and SA
Agoraphobia
Substance abuse
What is the difference between generalized social anxiety disorder and performance-only socail anxiety disorder?
Performance only is related only to public speaking, presentations, or performers
How does the treatment differ between generalized social anxiety and performance only?
Generalized needs to be treatment with SSRIs and CBT, while performance only can be treated with Benzos or Beta blockers
What is a key symptoms of body dysmorphic disorder?
Repetitive behavior or mental acts performed in response to preoccupation.
What is the preferred monotherapy for mild to moderate bipolar disorder?
Atypical antipsychotics
Lithium or valproic acid may also be used
What is the preferred treatment protocol for severe episodes of bipolar disorder?
Combonation therapy with lithium or valproic acid plus an atypical antipsychotic
What disorders can be treated with CBT?
Anxiety Mood Personality Somatic symptoms Eating disorder
What distortions can be treated with CBT?
Overgeneralization of negative events
Catastrophizing
Minimizing positive events
What type of psychotherapy would you use to treat a patient with relationship conflicts, life role transitions, or grief?
Interpersonal
- Current relationships and conflicts
What type of psychotherapy would you use to treat a patient with low functioning, in crisis, psychotic, or cognitively impaired?
Supportive threapy
- Coping skills (Adaptive defense mechanisms)
What type of psychotherapy would you use to treat a patient with high function, persistent patterns of dysfunction, or more neurotic?
Psychodynamic
- Past relationships/conflicts
- Uses treansference
- Break down defense mechanisms
What type of psychotherapy would you use to treat a patient with substance abuse disroder?
Motivational interview
- Address ambivalence to change
- Enhance motivaiton to changes
- Acknowledge resistance
What type of psychotherapy would you use to treat a patient with persistent maladaptive thoughts, avoidance behavior, or ability to participated in homework?
CBT
- ID and change maladaptive behavior
- Change emotions and behavior caused by thoughts
- Behavioral techniques (breathing, exposure, goal-setting, visualization)
What type of psychotherapy would you use to treat a patient with borderline personality disorder or self injurious behavior?
Dialectical behavior therapy
- Acceptance and change
- Improve emotion regulation, mindful awareness, disress tolerance
- Manage self harm
- Group therapy component
What type of psychotherapy would you use to treat a patient when prominent physical response accompany psychiatirc symtpoms?
Biofeedback
- Improve awareness and control over physiological reactins
- Lower stress levels
- Integrate mind and body
What is the most effective line of treatment for a manic patient presenting with acute agitation?
Antipsychotics
- Atypical first then typical
What are lithium, valproate, and carbamazepine not as effective at treating acute agitation in acute mania?
They require titration
In which medical condition should lithium be avoided?
Patients with renal disease
In which medical condition should valproate be avoided?
Liver disease
What is the main concern with using carbamazepine?
CYP induction
What is the time requirement for GAD/
6+ months
What are the symptoms associated with GAD?
MS. FRIC
Muscle tension
Sleep disturbances
Fatigue
Restlessness
Irritability
Concentration
How many symptoms are needed to meet critera for GAD?
3+
Excessive anxiety and preoccupation with 1+ unexplained symp
Somatic symptoms disorder
Fear of having a serious illness despite few or no symptoms & consistently negative evaluations
Illness anxiety disorder
Neurologic symptoms incompatible with any known neurologic disease; often acute onset associated with stress
Conversion disorder (functional neurologic symptoms disorder)
Intentional falsificataion or inducement of symptoms with goal to assume sick role
Factitious disorder
Falsification or exaggeration of symptoms to obtain external incentives (secondary gain)
Malingering